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     See license terms at www.gsea-msigdb.org/gsea/license_terms_list. Please note that certain gene sets have special access terms.
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<MSIGDB BUILD_DATE="Jan 29, 2026" VERSION="2026.1.Hs" NAME="export">
    <GENESET STANDARD_NAME="BIOCARTA_VIP_PATHWAY" SYSTEMATIC_NAME="M17941" HISTORICAL_NAMES="" PMID="" AUTHORS="" GEOID="" EXACT_SOURCE="" GENESET_LISTING_URL="" EXTERNAL_DETAILS_URL="https://data.broadinstitute.org/gsea-msigdb/msigdb/biocarta/human/h_vipPathway.gif" CHIP="HUMAN_SEQ_ACCESSION" CONTRIBUTOR="BioCarta" CONTRIBUTOR_ORG="BioCarta" DESCRIPTION_BRIEF="Neuropeptides VIP and PACAP inhibit the apoptosis of activated T cells" DESCRIPTION_FULL="Vasoactive intestinal peptide (VIP) and the structurally related pituitary adenylate cyclase-activating polypeptide (PACAP), two neuropeptides present in the lymphoid microenvironment, elicit a broad spectrum of biological functions, including the modulation of innate and adaptive immunity. Another important immunoregulatory function of VIP and PACAP is their inhibition effect on AICD in T cells. They inhibit the TCR-stimulated FasL expression and apoptosis of T cell through specific receptors and induction of intracellular cAMP. VIP down-regulate c-Myc synthesis, the NF-AT-dependent Egr2 and Egr3 expression, the NF-AT and NF-kB." TAGS="" MEMBERS="BC045628,BQ218507,NM_000399,NM_000944,NM_001130691,NM_001130692,NM_001136021,NM_001136177,NM_001136178,NM_001136179,NM_001142353,NM_001142354,NM_001145138,NM_001164758,NM_001164759,NM_001164760,NM_001164761,NM_001164762,NM_001165412,NM_001199880,NM_001199881,NM_001242857,NM_001242858,NM_001242859,NM_001242860,NM_001242861,NM_001242862,NM_001243974,NM_001243975,NM_001243984,NM_001243985,NM_001258292,NM_001258294,NM_001258295,NM_001258296,NM_001258297,NM_001278,NM_001743,NM_002072,NM_002467,NM_002660,NM_002731,NM_002732,NM_002734,NM_002735,NM_002736,NM_003381,NM_003382,NM_003998,NM_004157,NM_004430,NM_005184,NM_005605,NM_005921,NM_006162,NM_006888,NM_012340,NM_020529,NM_021132,NM_021975,NM_172387,NM_172388,NM_172389,NM_172390,NM_173091,NM_182811,NM_182948,NM_194435,NM_207578,NM_212471,NM_212472" MEMBERS_SYMBOLIZED="CALM1,CALM2,CALM3,CHUK,EGR2,EGR3,GNAQ,MAP3K1,MYC,NFATC1,NFATC2,NFKB1,NFKBIA,PLCG1,PPP3CA,PPP3CB,PPP3CC,PRKACB,PRKACG,PRKAR1A,PRKAR1B,PRKAR2A,PRKAR2B,RELA,VIP,VIPR2" MEMBERS_EZID="1147,1959,1960,2776,4214,4609,4772,4773,4790,4792,5335,5530,5532,5533,5567,5568,5573,5575,5576,5577,5970,7432,7434,801,805,808" MEMBERS_MAPPING="BC045628,NFATC1,4772|BQ218507,CALM1,801|NM_000399,EGR2,1959|NM_000944,PPP3CA,5530|NM_001130691,PPP3CA,5530|NM_001130692,PPP3CA,5530|NM_001136021,NFATC2,4773|NM_001136177,EGR2,1959|NM_001136178,EGR2,1959|NM_001136179,EGR2,1959|NM_001142353,PPP3CB,5532|NM_001142354,PPP3CB,5532|NM_001145138,RELA,5970|NM_001164758,PRKAR1B,5575|NM_001164759,PRKAR1B,5575|NM_001164760,PRKAR1B,5575|NM_001164761,PRKAR1B,5575|NM_001164762,PRKAR1B,5575|NM_001165412,NFKB1,4790|NM_001199880,EGR3,1960|NM_001199881,EGR3,1960|NM_001242857,PRKACB,5567|NM_001242858,PRKACB,5567|NM_001242859,PRKACB,5567|NM_001242860,PRKACB,5567|NM_001242861,PRKACB,5567|NM_001242862,PRKACB,5567|NM_001243974,PPP3CC,5533|NM_001243975,PPP3CC,5533|NM_001243984,RELA,5970|NM_001243985,RELA,5970|NM_001258292,NFATC2,4773|NM_001258294,NFATC2,4773|NM_001258295,NFATC2,4773|NM_001258296,NFATC2,4773|NM_001258297,NFATC2,4773|NM_001278,CHUK,1147|NM_001743,CALM2,805|NM_002072,GNAQ,2776|NM_002467,MYC,4609|NM_002660,PLCG1,5335|NM_002731,PRKACB,5567|NM_002732,PRKACG,5568|NM_002734,PRKAR1A,5573|NM_002735,PRKAR1B,5575|NM_002736,PRKAR2B,5577|NM_003381,VIP,7432|NM_003382,VIPR2,7434|NM_003998,NFKB1,4790|NM_004157,PRKAR2A,5576|NM_004430,EGR3,1960|NM_005184,CALM3,808|NM_005605,PPP3CC,5533|NM_005921,MAP3K1,4214|NM_006162,NFATC1,4772|NM_006888,CALM1,801|NM_012340,NFATC2,4773|NM_020529,NFKBIA,4792|NM_021132,PPP3CB,5532|NM_021975,RELA,5970|NM_172387,NFATC1,4772|NM_172388,NFATC1,4772|NM_172389,NFATC1,4772|NM_172390,NFATC1,4772|NM_173091,NFATC2,4773|NM_182811,PLCG1,5335|NM_182948,PRKACB,5567|NM_194435,VIP,7432|NM_207578,PRKACB,5567|NM_212471,PRKAR1A,5573|NM_212472,PRKAR1A,5573" FILTERED_BY_SIMILARITY="" FOUNDER_NAMES="" REFINEMENT_DATASETS="" VALIDATION_DATASETS="" CATEGORY_CODE="C2" ORGANISM="Homo sapiens" SUB_CATEGORY_CODE="CP:BIOCARTA"/>
</MSIGDB>
