STANDARD_NAME	BUCASAS_PBMC_FLUARIX_FLUVIRIN_CAUCASIAN_MALE_AGE_18_40YO_HIGH_RESPONDERS_1DY_TOP_FUNCTIONAL_NETWORK_POSITIVE
SYSTEMATIC_NAME	M41054
COLLECTION	C7:VAX
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/BUCASAS_PBMC_FLUARIX_FLUVIRIN_CAUCASIAN_MALE_AGE_18_40YO_HIGH_RESPONDERS_1DY_TOP_FUNCTIONAL_NETWORK_POSITIVE
NAMESPACE	HUMAN_GENE_SYMBOL
DESCRIPTION_BRIEF	Genes positively correlated with a functional network in peripheral blood mononuclear cell in Caucasian male adults (18-40) (high responders) after exposure to Fluarix/Fluvirin , time point 1D. Comment: Top functional network for genes preferentially upregulated in the high responder group
DESCRIPTION_FULL	BACKGROUND: Annual vaccination is the primary means for preventing influenza. However, great interindividual variability exists in vaccine responses, the cellular events that take place in vivo after vaccination are poorly understood, and appropriate biomarkers for vaccine responsiveness have not been developed. METHODS: We immunized a cohort of healthy male adults with a licensed trivalent influenza vaccine and performed a timed assessment of global gene expression before and after vaccination. We analyzed the relationship between gene expression patterns and the humoral immune response to vaccination. RESULTS: Marked up regulation of expression of genes involved in interferon signaling, positive IL-6 regulation, and antigen processing and presentation, were detected within 24 hours of immunization. The late vaccine response showed a transcriptional pattern suggestive of increased protein biosynthesis and cellular proliferation. Integrative analyses revealed a 494-gene expression signature--including STAT1, CD74, and E2F2--which strongly correlates with the magnitude of the antibody response. High vaccine responder status correlates with increased early expression of interferon signaling and antigen processing and presentation genes. CONCLUSIONS: The results highlight the role of a systems biology approach in understanding the molecular events that take place in vivo after influenza vaccination and in the development of better predictors of vaccine responsiveness.
PMID	21357945
GEOID	
AUTHORS	Bucasas KL,Franco LM,Shaw CA,Bray MS,Wells JM,Niño D,Arden N,Quarles JM,Couch RB,Belmont JW
CONTRIBUTOR	HIPC SIGNATURES
CONTRIBUTOR_ORG	NIAID/HIPC SIGNATURES
EXACT_SOURCE	Fig 3C
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3068032/figure/fig3/
SOURCE_MEMBERS	CD27,CORO1A,CSF2RA,DAPP1,FCGR1A,HLA-G,IRF9,ISG15,LILRB1,LILRB3,PIGR,PNPT1,PRKD2,RBCK1,SNRNP70,STAT1,STAT2,TAPBP,TNFSF14
GENE_SYMBOLS	CD27,CORO1A,CSF2RA,DAPP1,FCGR1A,HLA-G,IRF9,ISG15,LILRB1,LILRB3,PIGR,PNPT1,PRKD2,RBCK1,SNRNP70,STAT1,STAT2,TAPBP,TNFSF14
FOUNDER_NAMES