STANDARD_NAME	BYSTRYKH_HEMATOPOIESIS_STEM_CELL_FLI1
SYSTEMATIC_NAME	M3254
COLLECTION	C2:CGP
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/BYSTRYKH_HEMATOPOIESIS_STEM_CELL_FLI1
NAMESPACE	AFFY_MG_U74
DESCRIPTION_BRIEF	Genes whose expression is coregulated with that of FLI1 [GeneID=2313] in hematopoietic stem cells (HSC).
DESCRIPTION_FULL	We combined large-scale mRNA expression analysis and gene mapping to identify genes and loci that control hematopoietic stem cell (HSC) function. We measured mRNA expression levels in purified HSCs isolated from a panel of densely genotyped recombinant inbred mouse strains. We mapped quantitative trait loci (QTLs) associated with variation in expression of thousands of transcripts. By comparing the physical transcript position with the location of the controlling QTL, we identified polymorphic cis-acting stem cell genes. We also identified multiple trans-acting control loci that modify expression of large numbers of genes. These groups of coregulated transcripts identify pathways that specify variation in stem cells. We illustrate this concept with the identification of candidate genes involved with HSC turnover. We compared expression QTLs in HSCs and brain from the same mice and identified both shared and tissue-specific QTLs. Our data are accessible through WebQTL, a web-based interface that allows custom genetic linkage analysis and identification of coregulated transcripts.
PMID	15711547
GEOID	GSE2031
AUTHORS	Bystrykh L,Weersing E,Dontje B,Sutton S,Pletcher MT,Wiltshire T,Su AI,Vellenga E,Wang J,Manly KF,Lu L,Chesler EJ,Alberts R,Jansen RC,Williams RW,Cooke MP,de Haan G
CONTRIBUTOR	Jean Junior
CONTRIBUTOR_ORG	MSigDB Team
EXACT_SOURCE	Table 3: Fli1
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	102265_at,102873_at,103530_at,160687_r_at,93231_at,95296_r_at,96941_at,98500_at,98731_at
GENE_SYMBOLS	MYF6,TAP2,FANCG,DBF4,HIC1,,IFT27,IL1RL1,RAB5B
FOUNDER_NAMES