STANDARD_NAME CAIRO_HEPATOBLASTOMA_DN SYSTEMATIC_NAME M13449 COLLECTION C2:CGP MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/CAIRO_HEPATOBLASTOMA_DN NAMESPACE AFFY_HG_U133 DESCRIPTION_BRIEF Genes down-regulated in hepatoblastoma samples compared to normal liver tissue. DESCRIPTION_FULL Hepatoblastoma, the most common pediatric liver cancer, is tightly linked to excessive Wnt/beta-catenin signaling. Here, we used microarray analysis to identify two tumor subclasses resembling distinct phases of liver development and a discriminating 16-gene signature. beta-catenin activated different transcriptional programs in the two tumor types, with distinctive expression of hepatic stem/progenitor markers in immature tumors. This highly proliferating subclass was typified by gains of chromosomes 8q and 2p and upregulated Myc signaling. Myc-induced hepatoblastoma-like tumors in mice strikingly resembled the human immature subtype, and Myc downregulation in hepatoblastoma cells impaired tumorigenesis in vivo. Remarkably, the 16-gene signature discriminated invasive and metastatic hepatoblastomas and predicted prognosis with high accuracy. PMID 19061838 GEOID E-MEXP-1851,E-MEXP-1852,E-MEXP-1853 AUTHORS Cairo S,Armengol C,De Reyniès A,Wei Y,Thomas E,Renard CA,Goga A,Balakrishnan A,Semeraro M,Gresh L,Pontoglio M,Strick-Marchand H,Levillayer F,Nouet Y,Rickman D,Gauthier F,Branchereau S,Brugières L,Laithier V,Bouvier R,Boman F,Basso G,Michiels JF,Hofman P,Arbez-Gindre F,Jouan H,Rousselet-Chapeau MC,Berrebi D,Marcellin L,Plenat F,Zachar D,Joubert M,Selves J,Pasquier D,Bioulac-Sage P,Grotzer M,Childs M,Fabre M,Buendia MA CONTRIBUTOR Arthur Liberzon CONTRIBUTOR_ORG MSigDB Team EXACT_SOURCE Table 3S: Fold change HB/NL <= 0.5 FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS 1494_f_at,200796_s_at,200797_s_at,200986_at,201328_at,201329_s_at,201339_s_at,201565_s_at,201625_s_at,201743_at,201920_at,201963_at,201995_at,202003_s_at,202237_at,202238_s_at,202241_at,202366_at,202459_s_at,202460_s_at,202502_at,202613_at,202627_s_at,202628_s_at,202675_at,202723_s_at,202724_s_at,202783_at,202784_s_at,202794_at,202847_at,202912_at,202929_s_at,202959_at,202960_s_at,203021_at,203058_s_at,203060_s_at,203233_at,203372_s_at,203373_at,203499_at,203500_at,203509_at,203566_s_at,203574_at,203790_s_at,203814_s_at,203837_at,203913_s_at,204119_s_at,204121_at,204150_at,204224_s_at,204231_s_at,204263_s_at,204264_at,204428_s_at,204483_at,204608_at,204675_at,204704_s_at,204787_at,204824_at,204997_at,205012_s_at,205019_s_at,205042_at,205073_at,205141_at,205192_at,205221_at,205258_at,205307_s_at,205363_at,205384_at,205412_at,205439_at,205442_at,205478_at,205480_s_at,205498_at,205530_at,205531_s_at,205554_s_at,205566_at,205610_at,205613_at,205627_at,205633_s_at,205657_at,205695_at,205728_at,205730_s_at,205753_at,205769_at,205773_at,205790_at,205799_s_at,205813_s_at,205819_at,205844_at,205866_at,205871_at,205911_at,205943_at,205984_at,206007_at,206010_at,206034_at,206068_s_at,206069_s_at,206085_s_at,206153_at,206172_at,206210_s_at,206237_s_at,206262_at,206264_at,206265_s_at,206287_s_at,206305_s_at,206343_s_at,206344_at,206380_s_at,206396_at,206424_at,206514_s_at,206610_s_at,206643_at,206697_s_at,206727_at,206753_at,206754_s_at,206755_at,206756_at,206797_at,206878_at,206930_at,206938_at,206979_at,207007_at,207027_at,207041_at,207076_s_at,207096_at,207102_at,207185_at,207201_s_at,207202_s_at,207218_at,207255_at,207262_at,207275_s_at,207330_at,207498_s_at,207537_at,207584_at,207609_s_at,207621_s_at,207630_s_at,207735_at,207804_s_at,207874_s_at,207883_s_at,207995_s_at,208126_s_at,208147_s_at,208158_s_at,208241_at,208288_at,208369_s_at,208383_s_at,208813_at,208960_s_at,208961_s_at,209301_at,209309_at,209365_s_at,209459_s_at,209460_at,209514_s_at,209515_s_at,209531_at,209540_at,209541_at,209581_at,209694_at,209696_at,209760_at,209916_at,209967_s_at,209980_s_at,210013_at,210143_at,210168_at,210233_at,210272_at,210301_at,210324_at,210326_at,210328_at,210473_s_at,210481_s_at,210521_s_at,210565_at,210678_s_at,210692_s_at,210852_s_at,210862_s_at,210889_s_at,210942_s_at,210959_s_at,211026_s_at,211056_s_at,211138_s_at,211224_s_at,211548_s_at,211549_s_at,211577_s_at,211689_s_at,212067_s_at,212143_s_at,212400_at,212560_at,212724_at,212736_at,212816_s_at,212856_at,212923_s_at,213113_s_at,213122_at,213279_at,213355_at,213375_s_at,213632_at,213664_at,213684_s_at,213706_at,213820_s_at,213832_at,214056_at,214142_at,214203_s_at,214235_at,214274_s_at,214279_s_at,214282_at,214307_at,214308_s_at,214413_at,214415_at,214621_at,214719_at,214829_at,214835_s_at,214889_at,214890_s_at,215014_at,215103_at,215498_s_at,215689_s_at,215712_s_at,215783_s_at,216058_s_at,217014_s_at,217127_at,217289_s_at,217521_at,217546_at,217647_at,217738_at,217739_s_at,217741_s_at,218002_s_at,218024_at,218245_at,218504_at,218532_s_at,218544_s_at,218653_at,218774_at,218804_at,218810_at,218918_at,218921_at,218935_at,218983_at,219059_s_at,219076_s_at,219195_at,219277_s_at,219313_at,219343_at,219377_at,219733_s_at,219954_s_at,220037_s_at,220070_at,220114_s_at,220313_at,220432_s_at,220496_at,220554_at,220786_s_at,220794_at,220801_s_at,221008_s_at,221009_s_at,221188_s_at,221305_s_at,221662_s_at,221766_s_at,221833_at,221834_at,221848_at,221928_at,222083_at,222121_at,222128_at,222291_at,222303_at,31835_at,32837_at,33494_at,37020_at,37201_at,37512_at,39248_at,39249_at,39763_at,43427_at,49452_at,52940_at,57539_at GENE_SYMBOLS CYP2A6,MCL1,MCL1,SERPING1,ETS2,ETS2,SCP2,ID2,INSIG1,CD14,SLC20A1,ACSL1,EXT1,ACAA2,NNMT,NNMT,TRIB1,ACADS,LPIN2,LPIN2,ACADM,CTPS1,SERPINE1,SERPINE1,SDHB,FOXO1,FOXO1,NNT,NNT,INPP1,PCK2,ADM,DDT,MMUT,MMUT,SLPI,PAPSS2,PAPSS2,IL4R,SOCS2,SOCS2,EPHA2,GCDH,SORL1,AGL,NFIL3,RIDA,NQO2,MAP3K5,HPGD,ADK,GADD45G,STAB1,GCH1,FAAH,CPT2,CPT2,LCAT,ENO3,ASL,SRD5A1,ALDOB,VSIG4,ENDOG,GPD1,HAGH,VIPR1,GNE,CYP2J2,ANG,MAP3K14,HGD,INHBB,KMO,BBOX1,FXYD1,ACAT1,GSTT2,MFAP3L,PPP1R1A,UGP2,GHR,ETFDH,GLS2,DNASE1L3,ABHD2,MYOM1,SYT17,CDA,ALAS1,HAAO,SDS,TENM1,ABLIM3,CRP,SLC27A2,CPEB3,SKAP1,SLC3A1,MAT1A,MARCO,VNN1,FCN3,PLG,PTH1R,TDO2,CRHBP,PRG4,HABP2,SERPINB8,ACADL,ACADL,CTH,CYP4F11,IL13RA2,CETP,NRG1,ADH1C,GPLD1,GPLD1,ITIH4,C8A,NRG1,PON1,CFP,SLC1A1,CYP26A1,CYP4F3,F11,HAL,HP,C9,RDH16,CYP2B6,CYP2B6,CHST7,NAT2,DAO,GLYAT,SRD5A2,C8B,NR1I3,HGFAC,MASP2,ASS1,SAA4,AKR1D1,SLC10A1,SLC22A1,NR1I2,F9,LEPR,APOF,ACSL1,PZP,CYP2D7,PFKFB1,LPA,CYP1A2,PEMT,CREM,RNF125,FCN2,CFHR4,TFR2,CLEC4M,CYP2C18,CYP2C8,OSBPL1A,NRG1,ABCB11,GCDH,PCK1,GOT1,KLF6,KLF6,CA2,AZGP1,ECM1,ABAT,ABAT,RAB27A,RAB27A,GSTZ1,IGF1,IGF1,PLAAT3,PTS,FBP1,TMEM131L,DHTKD1,CREM,SHMT1,HPX,ANXA10,C6,IL1RAP,CYP2B7P,XDH,C8G,AGXT,GNMT,ADGRA3,CLEC4M,FETUB,GCGR,AGPAT2,SLC43A3,AASS,SARDH,FCGR2B,ST3GAL6,SRD5A1,MGLL,SRD5A1,KMO,ABCB11,HPGD,HPGD,IGF1,TMPRSS2,C1R,IGFBP3,EEIG1,SORL1,RND3,BMERB1,CBS,GRAMD4,PXDC1,SLC43A3,TSPYL5,DHRS1,ST3GAL6,N4BP2L1,DHODH,SLC1A1,PDLIM5,GPD1,STARD5,KCND3,,ZG16,PRODH,CYP3A5,ACAA1,NDRG2,,HGD,HGD,,PLG,GYS2,SLC46A3,AASS,SUCLG2,FAM149A,FAM149A,KCND3,CYP2C18,MAP2K3,SHBG,IGFALS,ALPL,CYP2C19,AZGP1,CTH,SLC37A4,HAL,MT1M,DHODH,NAMPT,NAMPT,ZFAND5,CXCL14,MPC1,TSKU,FAHD2A,RETREG1,RCL1,SLC25A15,DCPS,ANO1,ZC3H12A,MAN1C1,SIGIRR,EHD3,C1RL,LYVE1,PXMP2,PPARGC1A,OGDHL,GRAMD1C,CDC37L1,GAREM1,SLC27A5,GBA3,LYVE1,KDM8,STAB2,GPR88,CYP39A1,CLEC1B,SLC22A7,SLC38A4,GREM2,HAO2,ETNPPL,ANGPTL4,CIDEB,UGT1A8,SLC22A7,TENT5A,LONP2,LONP2,ZGPAT,ACACB,GLYAT,ARHGEF26,,FAM149A,,HRG,AGPAT2,ETFDH,CRP,ITIH4,HSD17B6,AQP3,AQP3,HPX,ACACB,ACACB,SIGIRR,ZGPAT FOUNDER_NAMES