STANDARD_NAME CAIRO_HEPATOBLASTOMA_UP SYSTEMATIC_NAME M14601 COLLECTION C2:CGP MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/CAIRO_HEPATOBLASTOMA_UP NAMESPACE AFFY_HG_U133 DESCRIPTION_BRIEF Genes up-regulated in hepatoblastoma samples compared to normal liver tissue. DESCRIPTION_FULL Hepatoblastoma, the most common pediatric liver cancer, is tightly linked to excessive Wnt/beta-catenin signaling. Here, we used microarray analysis to identify two tumor subclasses resembling distinct phases of liver development and a discriminating 16-gene signature. beta-catenin activated different transcriptional programs in the two tumor types, with distinctive expression of hepatic stem/progenitor markers in immature tumors. This highly proliferating subclass was typified by gains of chromosomes 8q and 2p and upregulated Myc signaling. Myc-induced hepatoblastoma-like tumors in mice strikingly resembled the human immature subtype, and Myc downregulation in hepatoblastoma cells impaired tumorigenesis in vivo. Remarkably, the 16-gene signature discriminated invasive and metastatic hepatoblastomas and predicted prognosis with high accuracy. PMID 19061838 GEOID E-MEXP-1851,E-MEXP-1852,E-MEXP-1853 AUTHORS Cairo S,Armengol C,De Reyniès A,Wei Y,Thomas E,Renard CA,Goga A,Balakrishnan A,Semeraro M,Gresh L,Pontoglio M,Strick-Marchand H,Levillayer F,Nouet Y,Rickman D,Gauthier F,Branchereau S,Brugières L,Laithier V,Bouvier R,Boman F,Basso G,Michiels JF,Hofman P,Arbez-Gindre F,Jouan H,Rousselet-Chapeau MC,Berrebi D,Marcellin L,Plenat F,Zachar D,Joubert M,Selves J,Pasquier D,Bioulac-Sage P,Grotzer M,Childs M,Fabre M,Buendia MA CONTRIBUTOR Arthur Liberzon CONTRIBUTOR_ORG MSigDB Team EXACT_SOURCE Table 3S: Fold change HB/NL >= 2 FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS 200052_s_at,200064_at,200617_at,200648_s_at,200662_s_at,200726_at,200771_at,200778_s_at,200831_s_at,200882_s_at,200884_at,200897_s_at,200907_s_at,200910_at,200911_s_at,200998_s_at,200999_s_at,201074_at,201075_s_at,201128_s_at,201247_at,201275_at,201377_at,201378_s_at,201417_at,201448_at,201504_s_at,201515_s_at,201518_at,201528_at,201529_s_at,201555_at,201578_at,201636_at,201656_at,201667_at,201669_s_at,201670_s_at,201681_s_at,201746_at,201833_at,201839_s_at,201841_s_at,201874_at,201892_s_at,201918_at,201919_at,201940_at,201941_at,201943_s_at,201951_at,201952_at,201956_s_at,202047_s_at,202112_at,202165_at,202166_s_at,202184_s_at,202220_at,202246_s_at,202314_at,202326_at,202365_at,202478_at,202479_s_at,202491_s_at,202539_s_at,202540_s_at,202551_s_at,202561_at,202562_s_at,202754_at,202762_at,202813_at,202892_at,202908_at,202967_at,203298_s_at,203304_at,203429_s_at,203477_at,203482_at,203714_s_at,203774_at,203825_at,203878_s_at,204215_at,204528_s_at,204602_at,205020_s_at,205055_at,205097_at,205372_at,205380_at,205425_at,205449_at,205463_s_at,205807_s_at,205862_at,205880_at,205890_s_at,205923_at,206272_at,206286_s_at,206414_s_at,206571_s_at,206857_s_at,207513_s_at,207700_s_at,207812_s_at,208025_s_at,208647_at,208650_s_at,208659_at,208660_at,208682_s_at,208753_s_at,208754_s_at,208783_s_at,208843_s_at,208939_at,208999_at,209014_at,209043_at,209154_at,209160_at,209194_at,209218_at,209220_at,209242_at,209243_s_at,209268_at,209279_s_at,209550_at,209560_s_at,209585_s_at,209586_s_at,209610_s_at,209647_s_at,209787_s_at,210393_at,210460_s_at,210794_s_at,210869_s_at,210878_s_at,210950_s_at,210976_s_at,211202_s_at,211340_s_at,211538_s_at,212092_at,212094_at,212126_at,212145_at,212168_at,212186_at,212190_at,212218_s_at,212345_s_at,212474_at,212547_at,212554_at,212591_at,212605_s_at,212651_at,212675_s_at,212677_s_at,212690_at,212765_at,212776_s_at,212810_s_at,212846_at,212919_at,212921_at,212922_s_at,212928_at,212956_at,213002_at,213022_s_at,213023_at,213093_at,213168_at,213186_at,213194_at,213241_at,213562_s_at,213577_at,213581_at,213677_s_at,213720_s_at,213839_at,213864_s_at,213880_at,213904_at,213975_s_at,214948_s_at,214949_at,215001_s_at,215017_s_at,215177_s_at,215464_s_at,216199_s_at,217188_s_at,218019_s_at,218168_s_at,218181_s_at,218184_at,218257_s_at,218258_at,218332_at,218344_s_at,218350_s_at,218459_at,218526_s_at,218528_s_at,218594_at,218595_s_at,218622_at,218627_at,218641_at,218704_at,218788_s_at,218816_at,218847_at,218908_at,218909_at,219127_at,219137_s_at,219192_at,219221_at,219436_s_at,219485_s_at,219602_s_at,219616_at,219675_s_at,219682_s_at,219732_at,220202_s_at,220305_at,220755_s_at,221509_at,221522_at,221529_s_at,221558_s_at,221750_at,221824_s_at,221825_at,221830_at,221911_at,222077_s_at,222288_at,266_s_at,40093_at GENE_SYMBOLS ILF2,HSP90AB1,MLEC,GLUL,TOMM20,PPP1CC,LAMC1,SEPTIN2,SCD,PSMD4,CKB,PALLD,PALLD,CCT3,TACC1,CKAP4,CKAP4,SMARCC1,SMARCC1,ACLY,SREBF2,FDPS,UBAP2L,UBAP2L,SOX4,TIA1,TSN,TSN,CBX1,RPA1,RPA1,MCM3,PODXL,FXR1,ITGA6,GJA1,MARCKS,MARCKS,DLG5,TP53,HDAC2,EPCAM,HSPB1,MPZL1,IMPDH2,SLC25A36,SLC25A36,CPD,CPD,CPD,ALCAM,ALCAM,GNPAT,CBX6,VWF,PPP1R2,PPP1R2,NUP133,KHDC4,CDK4,CYP51A1,EHMT2,UNC119B,TRIB2,TRIB2,ELP1,HMGCR,HMGCR,CRIM1,TNKS,ERG28,R3HDM1,ROCK2,TARBP1,CDC23,WFS1,GSTA4,JARID2,BAMBI,SUCO,COL15A1,SLF2,TBCE,MTR,BRD3,MMP11,TMEM243,NAP1L1,DKK1,ARL4A,ITGAE,SLC26A2,PLAG1,PDZK1,HIP1,SAC3D1,PDGFA,TUFT1,GREB1,PRKD1,GABBR1,RELN,RAB4A,TDGF1,ASAP2,MAP4K4,FKBP1B,ZNF189,NCOA3,GORASP2,HMGA2,FDFT1,CD24P2,CLIC1,CS,MAGED2,NAP1L1,NAP1L1,CD46,GORASP2,SEPHS1,SEPTIN8,MAGED1,PAPSS1,TAX1BP3,AKR1C3,CETN2,SQLE,GPC3,PEG3,PEG3,VPS45,NSDHL,NDN,DLK1,MINPP1,PRUNE1,SLC1A4,SOCS5,HMGN4,LGR5,PSMD4,MEG3,MCAM,KDM3B,FDFT1,PFKM,KDM5B,MCAM,HSPA2,PEG10,PEG10,CBX5,MRPS27,RBM12,ACACA,SERPINE2,FASN,CREB3L2,AVL9,BRD3,CAP2,RBM34,NUDT3,RHOBTB1,CEP68,CEP68,DDHD2,CAMSAP2,OBSL1,SLC1A4,RRP1B,DCP2,,SMYD2,TSPYL4,TBC1D9,,UTRN,UTRN,PRKCA,SP3,DZIP3,ROBO1,PLXNC1,SQLE,SQLE,PDCD2,PMS1,SMARCA4,CLMN,NAP1L1,LGR5,FRRS1L,LYZ,POMK,POMK,GLUL,FNBP1L,ITGA6,TAX1BP3,MAP3K4,ERG28,PDXK,COQ8A,MAP4K4,TULP4,UGGT1,POLR1D,BEX1,RCOR3,GMNN,TOR3A,RANGRF,RNF38,HEATR1,HEATR1,NUP37,DRAM1,ZFTA,RNF43,SMYD3,LRRC1,IGF2BP2,ASPSCR1,RPS6KC1,PRR15L,MFF,UBAP2,ZBTB38,EMCN,PSMD10,PIEZO2,ACSS3,UXS1,TBX3,PLPPR1,RC3H2,MAVS,SNHG32,DENR,ANKRD27,PLVAP,LEF1,HMGCS1,MARCHF8,ANGEL2,RAP2A,ETV1,RACGAP1,,CD24,BCAM FOUNDER_NAMES