STANDARD_NAME	CAO_BLOOD_FLUMIST_AGE_05_14YO_1DY_UP
SYSTEMATIC_NAME	M41170
COLLECTION	C7:VAX
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/CAO_BLOOD_FLUMIST_AGE_05_14YO_1DY_UP
NAMESPACE	HUMAN_GENE_SYMBOL
DESCRIPTION_BRIEF	Genes up-regulated in blood 1d vs 0d in children (0.5-14y) after exposure to FluMist , time point 1D. Comment: ~80% of cohort were white, ~50/50 Female:male
DESCRIPTION_FULL	BACKGROUND: Live attenuated influenza vaccine (LAIV) and trivalent inactivated influenza vaccine (TIV) are effective for prevention of influenza virus infection in children, but the mechanisms associated with protection are not well defined. METHODS: We analyzed the differences in B-cell responses and transcriptional profiles in children aged 6 months to 14 years immunized with these 2 vaccines. RESULTS: LAIV elicited a significant increase in naive, memory, and transitional B cells on day 30 after vaccination, whereas TIV elicited an increased number of plasmablasts on day 7. Antibody titers against the 3 vaccine strains (H1N1, H3N2, and B) were significantly higher in the TIV group and correlated with number of antibody-secreting cells. Both vaccines induced overexpression of interferon (IFN)-signaling genes but with different kinetics. TIV induced expression of IFN genes on day 1 after vaccination in all age groups, and LAIV induced expression of IFN genes on day 7 after vaccination but only in children < 5 years old. IFN-related genes overexpressed in both vaccinated groups correlated with H3N2 antibody titers. CONCLUSIONS: These results suggest that LAIV and TIV induced significantly different B-cell responses in vaccinated children. Early induction of IFN appears to be important for development of antibody responses.
PMID	24495909
GEOID	
AUTHORS	Cao RG,Suarez NM,Obermoser G,Lopez SM,Flano E,Mertz SE,Albrecht RA,García-Sastre A,Mejias A,Xu H,Qin H,Blankenship D,Palucka K,Pascual V,Ramilo O
CONTRIBUTOR	HIPC SIGNATURES
CONTRIBUTOR_ORG	NIAID/HIPC SIGNATURES
EXACT_SOURCE	Suppl Table 1
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4092249/bin/supp_jiu079_jiu079supp_table1.doc
SOURCE_MEMBERS	CHTF8,CPT1A,DSCC1,FLVCR1,STK40,TRAPPC6B,URB1
GENE_SYMBOLS	CHTF8,CPT1A,DSCC1,FLVCR1,STK40,TRAPPC6B,URB1
FOUNDER_NAMES