STANDARD_NAME	CHEN_ETV5_TARGETS_TESTIS
SYSTEMATIC_NAME	M1664
COLLECTION	C2:CGP
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/CHEN_ETV5_TARGETS_TESTIS
NAMESPACE	MOUSE_SEQ_ACCESSION
DESCRIPTION_BRIEF	Genes down-regulated in testis from 4 week old ETV5 [GeneID=2119] knockout mice.
DESCRIPTION_FULL	Division of spermatogonial stem cells produces daughter cells that either maintain their stem cell identity or undergo differentiation to form mature sperm. The Sertoli cell, the only somatic cell within seminiferous tubules, provides the stem cell niche through physical support and expression of surface proteins and soluble factors. Here we show that the Ets related molecule (ERM) is expressed exclusively within Sertoli cells in the testis and is required for spermatogonial stem cell self-renewal. Mice with targeted disruption of ERM have a loss of maintenance of spermatogonial stem cell self-renewal without a block in normal spermatogenic differentiation and thus have progressive germ-cell depletion and a Sertoli-cell-only syndrome. Microarray analysis of primary Sertoli cells from ERM-deficient mice showed alterations in secreted factors known to regulate the haematopoietic stem cell niche. These results identify a new function for the Ets family transcription factors in spermatogenesis and provide an example of transcriptional control of a vertebrate stem cell niche.
PMID	16107850
GEOID	GSE2205
AUTHORS	Chen C,Ouyang W,Grigura V,Zhou Q,Carnes K,Lim H,Zhao GQ,Arber S,Kurpios N,Murphy TL,Cheng AM,Hassell JA,Chandrashekar V,Hofmann MC,Hess RA,Murphy KM
CONTRIBUTOR	John Newman
CONTRIBUTOR_ORG	University of Washington
EXACT_SOURCE	Table 1S
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	AA866668,AF091432,AI156310,AI197337,AI595812,AI596540,AI606257,AI840713,AJ223732,AV357533,AW061337,AW124460,D13803,D25540,D64107,D86725,L22977,U25691,U27177,U46694,U83902,X15789,X55316,X77731,X82786,Y15131,Z75287
GENE_SYMBOLS	SOX3,CCNE2,TKTL1,HAUS6,PACRGL,,CDCA7,RNF227,CDK2,CCNB1IP1,AK4,DDX10,RAD51,TGFBR1,DMC1,MCM2,FAM9C,HELLS,RBL1,DAZL,MAD2L1,CRABP1,NFYB,DCK,MKI67,RBMY1B,STRA8
FOUNDER_NAMES