STANDARD_NAME	CHEOK_RESPONSE_TO_MERCAPTOPURINE_AND_LD_MTX_UP
SYSTEMATIC_NAME	M11031
COLLECTION	C2:CGP
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/CHEOK_RESPONSE_TO_MERCAPTOPURINE_AND_LD_MTX_UP
NAMESPACE	AFFY_HG_U95
DESCRIPTION_BRIEF	Genes specifically up-regulated in pediatric acute lymphoblastic leukemia (ALL) patients by mercaptopurine [PubChem=667490] and low-dose methotrexate (LDMTX) [PubChem=4112].
DESCRIPTION_FULL	To elucidate the genomics of cellular responses to cancer treatment, we analyzed the expression of over 9,600 human genes in acute lymphoblastic leukemia cells before and after in vivo treatment with methotrexate and mercaptopurine given alone or in combination. Based on changes in gene expression, we identified 124 genes that accurately discriminated among the four treatments. Discriminating genes included those involved in apoptosis, mismatch repair, cell cycle control and stress response. Only 14% of genes that changed when these medications were given as single agents also changed when they were given together. These data indicate that lymphoid leukemia cells of different molecular subtypes share common pathways of genomic response to the same treatment, that changes in gene expression are treatment-specific and that gene expression can illuminate differences in cellular response to drug combinations versus single agents.
PMID	12704389
GEOID	GSE412
AUTHORS	Cheok MH,Yang W,Pui CH,Downing JR,Cheng C,Naeve CW,Relling MV,Evans WE
CONTRIBUTOR	Jean Junior
CONTRIBUTOR_ORG	MSigDB Team
EXACT_SOURCE	Table 2S: LDMP DC > 0 & LDMP p val. < 0.01
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	32695_at,33773_at,34307_at,38041_at,38472_at,39490_f_at,39717_g_at,40030_at,40377_at,40473_at,891_at
GENE_SYMBOLS	HTATSF1,MLLT10,TM9SF2,GALNT1,EFR3A,,MRPL33,PRKY,RBM19,STK24,YY1
FOUNDER_NAMES