STANDARD_NAME CHEOK_RESPONSE_TO_MERCAPTOPURINE_AND_LD_MTX_UP SYSTEMATIC_NAME M11031 COLLECTION C2:CGP MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/CHEOK_RESPONSE_TO_MERCAPTOPURINE_AND_LD_MTX_UP NAMESPACE AFFY_HG_U95 DESCRIPTION_BRIEF Genes specifically up-regulated in pediatric acute lymphoblastic leukemia (ALL) patients by mercaptopurine [PubChem=667490] and low-dose methotrexate (LDMTX) [PubChem=4112]. DESCRIPTION_FULL To elucidate the genomics of cellular responses to cancer treatment, we analyzed the expression of over 9,600 human genes in acute lymphoblastic leukemia cells before and after in vivo treatment with methotrexate and mercaptopurine given alone or in combination. Based on changes in gene expression, we identified 124 genes that accurately discriminated among the four treatments. Discriminating genes included those involved in apoptosis, mismatch repair, cell cycle control and stress response. Only 14% of genes that changed when these medications were given as single agents also changed when they were given together. These data indicate that lymphoid leukemia cells of different molecular subtypes share common pathways of genomic response to the same treatment, that changes in gene expression are treatment-specific and that gene expression can illuminate differences in cellular response to drug combinations versus single agents. PMID 12704389 GEOID GSE412 AUTHORS Cheok MH,Yang W,Pui CH,Downing JR,Cheng C,Naeve CW,Relling MV,Evans WE CONTRIBUTOR Jean Junior CONTRIBUTOR_ORG MSigDB Team EXACT_SOURCE Table 2S: LDMP DC > 0 & LDMP p val. < 0.01 FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS 32695_at,33773_at,34307_at,38041_at,38472_at,39490_f_at,39717_g_at,40030_at,40377_at,40473_at,891_at GENE_SYMBOLS HTATSF1,MLLT10,TM9SF2,GALNT1,EFR3A,,MRPL33,PRKY,RBM19,STK24,YY1 FOUNDER_NAMES