<?xml version="1.0" encoding="UTF-8" standalone="yes"?>

<!-- Copyright (c) 2004-2026 Broad Institute, Inc., Massachusetts Institute of Technology, and Regents of the University of California.  All rights reserved.
     See license terms at www.gsea-msigdb.org/gsea/license_terms_list. Please note that certain gene sets have special access terms.
-->
<MSIGDB BUILD_DATE="Jan 29, 2026" VERSION="2026.1.Hs" NAME="export">
    <GENESET STANDARD_NAME="CHEOK_RESPONSE_TO_MERCAPTOPURINE_AND_LD_MTX_UP" SYSTEMATIC_NAME="M11031" HISTORICAL_NAMES="" PMID="12704389" AUTHORS="Cheok MH,Yang W,Pui CH,Downing JR,Cheng C,Naeve CW,Relling MV,Evans WE" GEOID="GSE412" EXACT_SOURCE="Table 2S: LDMP DC &gt; 0 &amp; LDMP p val. &lt; 0.01" GENESET_LISTING_URL="" EXTERNAL_DETAILS_URL="" CHIP="AFFY_HG_U95" CONTRIBUTOR="Jean Junior" CONTRIBUTOR_ORG="MSigDB Team" DESCRIPTION_BRIEF="Genes specifically up-regulated in pediatric acute lymphoblastic leukemia (ALL) patients by mercaptopurine [PubChem=667490] and low-dose methotrexate (LDMTX) [PubChem=4112]." DESCRIPTION_FULL="To elucidate the genomics of cellular responses to cancer treatment, we analyzed the expression of over 9,600 human genes in acute lymphoblastic leukemia cells before and after in vivo treatment with methotrexate and mercaptopurine given alone or in combination. Based on changes in gene expression, we identified 124 genes that accurately discriminated among the four treatments. Discriminating genes included those involved in apoptosis, mismatch repair, cell cycle control and stress response. Only 14% of genes that changed when these medications were given as single agents also changed when they were given together. These data indicate that lymphoid leukemia cells of different molecular subtypes share common pathways of genomic response to the same treatment, that changes in gene expression are treatment-specific and that gene expression can illuminate differences in cellular response to drug combinations versus single agents." TAGS="" MEMBERS="32695_at,33773_at,34307_at,38041_at,38472_at,39490_f_at,39717_g_at,40030_at,40377_at,40473_at,891_at" MEMBERS_SYMBOLIZED="EFR3A,GALNT1,HTATSF1,MLLT10,MRPL33,PRKY,RBM19,STK24,TM9SF2,YY1" MEMBERS_EZID="23167,2589,27336,5616,7528,8028,8428,9375,9553,9904" MEMBERS_MAPPING="32695_at,HTATSF1,27336|33773_at,MLLT10,8028|34307_at,TM9SF2,9375|38041_at,GALNT1,2589|38472_at,EFR3A,23167|39490_f_at,null,null|39717_g_at,MRPL33,9553|40030_at,PRKY,5616|40377_at,RBM19,9904|40473_at,STK24,8428|891_at,YY1,7528" FILTERED_BY_SIMILARITY="" FOUNDER_NAMES="" REFINEMENT_DATASETS="" VALIDATION_DATASETS="" CATEGORY_CODE="C2" ORGANISM="Homo sapiens" SUB_CATEGORY_CODE="CGP"/>
</MSIGDB>
