STANDARD_NAME	CHESLER_BRAIN_QTL_TRANS
SYSTEMATIC_NAME	M7189
COLLECTION	C2:CGP
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/CHESLER_BRAIN_QTL_TRANS
NAMESPACE	AFFY_MG_U74
DESCRIPTION_BRIEF	Best trans-regulated quantitative trait loci (QTLs) in the mouse genome which modulate transcription in brain tissue.
DESCRIPTION_FULL	Patterns of gene expression in the central nervous system are highly variable and heritable. This genetic variation among normal individuals leads to considerable structural, functional and behavioral differences. We devised a general approach to dissect genetic networks systematically across biological scale, from base pairs to behavior, using a reference population of recombinant inbred strains. We profiled gene expression using Affymetrix oligonucleotide arrays in the BXD recombinant inbred strains, for which we have extensive SNP and haplotype data. We integrated a complementary database comprising 25 years of legacy phenotypic data on these strains. Covariance among gene expression and pharmacological and behavioral traits is often highly significant, corroborates known functional relations and is often generated by common quantitative trait loci. We found that a small number of major-effect quantitative trait loci jointly modulated large sets of transcripts and classical neural phenotypes in patterns specific to each tissue. We developed new analytic and graph theoretical approaches to study shared genetic modulation of networks of traits using gene sets involved in neural synapse function as an example. We built these tools into an open web resource called WebQTL that can be used to test a broad array of hypotheses.
PMID	15711545
GEOID	
AUTHORS	Chesler EJ,Lu L,Shou S,Qu Y,Gu J,Wang J,Hsu HC,Mountz JD,Baldwin NE,Langston MA,Threadgill DW,Manly KF,Williams RW
CONTRIBUTOR	Jean Junior
CONTRIBUTOR_ORG	MSigDB Team
EXACT_SOURCE	Table 2S: TRANS REGULATED TRANSCRIPTS
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	101516_at,102108_f_at,102696_s_at,103006_at,92426_at,94122_at,94472_at,96499_at,97282_at
GENE_SYMBOLS	CD59,MYH9,PITPNB,ATF5,TSPAN5,MYOC,,,
FOUNDER_NAMES