STANDARD_NAME	CHIARADONNA_NEOPLASTIC_TRANSFORMATION_KRAS_UP
SYSTEMATIC_NAME	M8795
COLLECTION	C2:CGP
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/CHIARADONNA_NEOPLASTIC_TRANSFORMATION_KRAS_UP
NAMESPACE	AFFY_MG_U74
DESCRIPTION_BRIEF	Genes up-regulated in transformed NIH3T3 cells (fibroblasts transformed by activated KRAS [GeneID=3845]) vs normal cells.
DESCRIPTION_FULL	Mutational activation of ras genes is required for the onset and maintenance of different malignancies. Here we show, using a combination of molecular physiology, nutritional perturbations and transcriptional profiling, that full penetrance of phenotypes related to oncogenic Ras activation, including the shift of carbon metabolism towards fermentation and upregulation of key cell cycle regulators, is dependent upon glucose availability. These responses are induced by Ras activation, being specifically reverted by downregulation of the Ras pathway obtained through the expression of a dominant-negative Ras-specific guanine nucleotide exchange protein. Our data allow to link directly to ras activation the alteration in energy metabolism of cancer cells, their fragility towards glucose shortage and ensuing apoptotic death.
PMID	16607279
GEOID	
AUTHORS	Chiaradonna F,Sacco E,Manzoni R,Giorgio M,Vanoni M,Alberghina L
CONTRIBUTOR	Lauren Kazmierski
CONTRIBUTOR_ORG	MSigDB Team
EXACT_SOURCE	Table 1S: kras-wt Up regulated genes
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	100064_f_at,100116_at,100153_at,100387_f_at,100612_at,100616_at,100906_at,100948_at,101065_at,101445_at,101464_at,101554_at,101589_at,101918_at,101963_at,101975_at,102001_at,102198_at,102248_f_at,102280_at,102409_at,102710_at,102736_at,102839_at,102905_at,103027_at,103071_at,103203_f_at,103204_r_at,103207_at,103416_at,103554_at,103556_at,103598_at,103797_at,103975_at,104149_at,104256_at,104257_g_at,104333_at,104469_at,104476_at,104527_at,160107_at,160204_at,160455_s_at,160461_f_at,160471_at,160489_at,160626_at,160648_at,160667_at,160799_at,160829_at,160857_at,161050_at,161070_at,161076_at,92544_f_at,92558_at,92562_at,92587_at,92639_at,92665_f_at,92738_at,92979_at,93019_at,93069_at,93122_at,93178_at,93180_at,93353_at,93371_at,93411_at,93557_at,93786_i_at,93823_at,93883_at,93929_s_at,93985_at,94040_at,94232_at,94303_at,94378_at,94415_at,94432_at,94502_at,94774_at,94776_f_at,94838_r_at,94930_at,95069_at,95117_at,95345_at,95462_at,95511_at,95523_at,95541_at,95608_at,95612_at,95625_at,95650_at,95694_at,95753_at,96024_at,96025_g_at,96041_at,96132_at,96345_at,96426_at,96662_at,96701_at,96862_at,97203_at,97302_at,97421_at,97445_at,97468_at,97519_at,97556_at,97770_s_at,98025_at,98026_g_at,98038_at,98101_at,98108_at,98136_at,98143_at,98409_at,98500_at,98501_at,98524_f_at,98525_f_at,98550_at,98586_at,98602_at,98802_at,98865_at,98981_s_at,98996_at,99058_at,99467_at,99500_at,99510_at,99535_at,99564_at,99578_at,99580_s_at,99849_at,99915_at,AFFX-MURINE_B2_at,MURINE_B2_at
GENE_SYMBOLS	GJA1,PCLAF,NCAM1,,RRM1,CENPA,ITGB7,ANKH,PCNA,DNMT1,TIMP1,NFKBIA,HMGN2,TGFB1,CTSV,DLK1,RRM2,KCNN4,CASK,PCDH7,LSM8,APBB1IP,CCL2,PLSCR1,CASP4,CXorf38,TOPBP1,E2F8,E2F8,POLA1,MAPK6,ADAM19,ANGPTL2,DHX9,CDC7,GREM2,NFKBIA,CYTIP,CYTIP,,PDPN,RBL1,RAD51,HPRT1,CENPV,ZWINT,TUBB6,SLBP,TNFAIP2,MYEF2,FIGNL1,EVL,,PHLDA1,EFNB2,NAV2,SPRED2,HAUS3,PSMA3,VCAM1,NFE2L2,FDX1,AURKA,SYCP3,GDNF,ETV4,H2AX,UBE2D2,CRISP3,NGEF,,LUM,BNC1,SEMA7A,SEPHS2,MRPL18,ILF2,,,TIPARP,ERH,CCND1,HNRNPD,RGS16,BACH1,ST6GAL1,MED10,,,,THBS2,SSRP1,IGF2R,TPBG,BZW2,ITGA6,,FAM3C,CTSB,RFC5,SLC6A8,SNU13,TOP1,NCAPH,AHCY,AHCY,RBM3,APCDD1,ERGIC3,TMSB4X,PLPP3,UBA2,SPTSSA,MARCKSL1,IVNS1ABP,SMC2,PPID,CKS1B,SPP1,ANP32E,FAM3C,EVI2A,EVI2A,HMGB3,GTF2A2,CRABP1,SMS,FUT8,MYO1B,IL1RL1,IL1RL1,,,SET,NAP1L1,RANGAP1,EREG,HAS2,TCF12,PLK4,HMGA2,RASA1,SLC12A2,PRKCB,NOCT,UHRF1,TOP2A,UGT1A10,,AREG,,
FOUNDER_NAMES