STANDARD_NAME	CHIARETTI_T_ALL_RELAPSE_PROGNOSIS
SYSTEMATIC_NAME	M17204
COLLECTION	C2:CGP
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/CHIARETTI_T_ALL_RELAPSE_PROGNOSIS
NAMESPACE	HUMAN_GENE_SYMBOL
DESCRIPTION_BRIEF	Genes whose expression predicted relapse in less than 2 years after chemotherapy for adult patients with T-ALL (T cell lymphoblastic leukemia).
DESCRIPTION_FULL	Gene expression profiles were examined in 33 adult patients with T-cell acute lymphocytic leukemia (T-ALL). Nonspecific filtering criteria identified 313 genes differentially expressed in the leukemic cells. Hierarchical clustering of samples identified 2 groups that reflected the degree of T-cell differentiation but was not associated with clinical outcome. Comparison between refractory patients and those who responded to induction chemotherapy identified a single gene, interleukin 8 (IL-8), that was highly expressed in refractory T-ALL cells and a set of 30 genes that was highly expressed in leukemic cells from patients who achieved complete remission. We next identified 19 genes that were differentially expressed in T-ALL cells from patients who either had a relapse or remained in continuous complete remission. A model based on the expression of 3 of these genes was predictive of duration of remission. The 3-gene model was validated on a further set of T-ALL samples from 18 additional patients treated on the same clinical protocol. This study demonstrates that gene expression profiling can identify a limited number of genes that are predictive of response to induction therapy and remission duration in adult patients with T-ALL.
PMID	14684422
GEOID	
AUTHORS	Chiaretti S,Li X,Gentleman R,Vitale A,Vignetti M,Mandelli F,Ritz J,Foa R
CONTRIBUTOR	Arthur Liberzon
CONTRIBUTOR_ORG	MSigDB Team
EXACT_SOURCE	Fig. 3
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	AHNAK,BUB1B,CAT,CD2,CD8,CDC7L1,CENPF,CHC1L,DEK,H2AFX,HEC,HNRPH1,KIAA0175,LRMP,MEF2A,MYC,SEC31B-1,TTK,USP1
GENE_SYMBOLS	AHNAK,BUB1B,CAT,CD2,CD8A,CDC7,CENPF,RCBTB2,DEK,H2AX,NDC80,HNRNPH1,MELK,IRAG2,MEF2A,MYC,SEC31B,TTK,USP1
FOUNDER_NAMES