STANDARD_NAME CHICAS_RB1_TARGETS_CONFLUENT SYSTEMATIC_NAME M2129 COLLECTION C2:CGP MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/CHICAS_RB1_TARGETS_CONFLUENT NAMESPACE AFFY_HG_U133 DESCRIPTION_BRIEF Genes up-regulated in confluent IMR90 cells (fibroblast) after knockdown of RB1 [GeneID=5925] by RNAi. DESCRIPTION_FULL The RB protein family (RB, p107, and p130) has overlapping and compensatory functions in cell-cycle control. However, cancer-associated mutations are almost exclusively found in RB, implying that RB has a nonredundant role in tumor suppression. We demonstrate that RB preferentially associates with E2F target genes involved in DNA replication and is uniquely required to repress these genes during senescence but not other growth states. Consequently, RB loss leads to inappropriate DNA synthesis following a senescence trigger and, together with disruption of a p21-mediated cell-cycle checkpoint, enables extensive proliferation and rampant genomic instability. Our results identify a nonredundant RB effector function that may contribute to tumor suppression and reveal how loss of RB and p53 cooperate to bypass senescence. PMID 20385362 GEOID GSE19899 AUTHORS Chicas A,Wang X,Zhang C,McCurrach M,Zhao Z,Mert O,Dickins RA,Narita M,Zhang M,Lowe SW CONTRIBUTOR Arthur Liberzon CONTRIBUTOR_ORG MSigDB Team EXACT_SOURCE Table 2S: confluent_shRb_up FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS 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GENE_SYMBOLS PXK,DEFB106A,LACTB,RHBDL2,NAV3,KDM1B,PDE5A,HEATR9,C18orf54,MSRB3,MOXD1,LMNA,TYMS,KLF7,KRTAP2-3,TAGLN,,POSTN,SLC7A14,,ITGBL1,APOL6,CAVIN1,,TMED4,,,PDE5A,PDE5A,SPOCD1,,PIK3R2,,LINC02861,MYLK,GAS6,ACTN4,WDR1,WARS1,WARS1,SPARC,CD81,GSN,PEA15,ACTB,SARS1,ZYX,PRDX6,PRDX6,FLNA,DHCR24,S100A10,PALLD,PALLD,ACTA2,ANXA6,SERPING1,UBE2V1,CD9,ANXA1,CD99,CD99,GNAI2,TGM2,MYL9,PXN,TUBA1A,GPX4,THBS1,CPE,CPE,SLC7A5,PKM,BGN,DAB2,NREP,NREP,IFITM2,ZFP36L2,ITGA5,PHGDH,VIM,DPYSL3,DPYSL3,CNN3,ANXA2,CNN2,ITGA6,EPB41L2,EPB41L2,MTHFD2,TMEM106C,FBLN1,MYOF,RTL8C,HSPB1,LIPA,CAPG,COL3A1,DCN,FARP1,MCM6,CAPZB,MEST,SFRP1,SDC4,OPTN,OPTN,TJP2,TSPO,ARHGAP1,PLIN3,LY6E,TUBB2A,GAS6,MVP,BLVRB,LAMA4,ARL4C,ARL4C,NNMT,NNMT,GBP1,ACTG2,G6PD,SERPINF1,CTSH,COL1A1,COL1A1,MATN2,SPOCK1,TRAM2,TRAM2,COL1A2,COL1A2,PRSS23,PCOLCE,DHRS3,PCLAF,MYLK,AK1,TYMS,SERPINE1,SERPINE1,AXL,AXL,STK17A,TES,PIK3R3,GBP2,GPC1,FBN1,FBN1,SYNPO,PCK2,ANPEP,SDC3,FHL2,ARNT2,C7,FBLN1,FBLN1,LOXL2,MTSS1,CAV1,GPRC5A,TRIM14,MAP1A,ALDH1A3,FBN2,RASSF2,S100A4,TLN1,CAV2,CAV2,COL5A1,PDLIM7,LMNA,RBP1,COL15A1,LOXL1,GPRC5B,FRZB,EMP3,LMOD1,SEMA3C,IL32,IGFBP6,VCAM1,HPGD,CNN1,NMI,SYT1,QPRT,FRY,TPM2,TUBB2A,RAD51AP1,DCTN3,PSMB9,LOX,RGS10,AGA,GSTM1,KIF11,CDC7,TOX,RAB40B,GSTM1,CROT,SRD5A1,LTBP2,NPTX1,HHEX,NFE2L3,NAV3,MELK,PSG5,GMDS,UGCG,SHROOM2,NMT2,ARL4A,CCNE2,ASNS,PRIM1,MAMLD1,PSPH,CLEC3B,PDGFRL,NR3C2,SNTB2,MN1,LRRC17,SMAD3,ITGBL1,PRSS12,EXOG,RUNX1T1,RUNX1T1,TAGLN,SNX7,HOXB5,WNT2,NRXN3,ROR1,SIX1,,SLC14A1,ITGA4,POLE2,RELN,RAB3B,HMGA1,CPM,TPM1,TPM1,PTX3,FOXD1,IFI16,RARRES1,RARRES1,FMO3,EFEMP2,GDF5,PTGER2,APOBEC3B,PDE5A,CCN4,OXTR,HBD,CLDN11,SCN9A,CDKN2A,ASS1,TNFSF4,SERPINH1,METTL7A,ACOT7,PTGIS,OSBPL1A,PSG4,PSG1,,PRPS1,RRAS2,PPARG,PDLIM1,GARS1,C1S,FLOT1,CAVIN1,CLU,CLU,ANXA2P2,THY1,THY1,SRI,TGFBR2,IFI16,IFI16,TUBB4B,TUBB,CADM1,CADM1,CADM1,MDK,TUBA1A,NR2F2,NR2F2,COL6A2,DEPP1,TUBB6,NUPR1,TUBA1C,CDC42EP3,CDC42EP3,CDC42EP3,DCN,ECM1,SMPD1,PRPS1,RAP1GDS1,ABAT,ABAT,PTN,PTN,OSBPL1A,CD200,EPHB2,SLC1A4,ADH1B,ADH1B,OSBPL3,TMEM47,SMAGP,CXCL12,MOXD1,ADAM19,PTCH1,TSPAN5,TP53TG1,FAP,GATA6,OLR1,CARD10,KCNH2,IDH2,B3GALT2,PMP22,FLOT1,TRIOBP,MAB21L2,ANXA2,FN1,INHBE,MFGE8,TP53I3,POSTN,TPM1,TPM1,TUBA1A,TUBA1B,COL3A1,BMP4,TUBB,FN1,PTN,ICA1,TUBA1C,TBCB,DCN,MYOF,DCN,MYH9,AHNAK,C1R,COL6A1,MTUS1,MTUS1,MTUS1,CAV1,ATP2B4,ATP2B4,FKBP9,MPRIP,IFITM3,GALNT10,TMEM97,SLC7A1,NRP1,TUBB,SULF1,SULF1,SULF1,CLIP3,NOTCH2,FN1,COL5A1,COL5A1,CHN1,TUBA1A,SPARC,MFAP4,RNF115,SLC1A4,SLC1A4,CBS,HEG1,ANGPTL2,ANGPTL2,CAVIN3,CREB3L1,HEG1,OLFML2A,ADGRG6,TENM4,COL6A2,MTCL1,ITGA4,COL6A1,TUBB2A,PLPPR4,ANXA2,F2RL1,SGCD,CAND2,ATP6V0E2,LOX,TUBA1A,DIPK1A,ELOVL2,XYLT1,TUBB4B,FLNA,RBMX,PRSS12,ACTB,THY1,BGN,TWIST1,RABGAP1L,TUBB2B,,,,MAN1C1,,SHMT2,SGCD,MACROH2A1,FN1,ADD1,FLNA,HSPB6,CDH6,DOK5,ITGBL1,NR2F2,COL3A1,LOX,SPATS2L,ZYX,PRIM2,CYB5A,HHEX,DIPK1A,MCM5,UBE2V1P3,FN1,,,KIAA0930,B3GALT2,S100A6,EVL,TNS3,BACE2,NIBAN1,NIBAN1,SNN,NT5DC2,UBR7,OLFML3,NAV2,TMEM176A,NLRP1,CARHSP1,STEAP3,SNRNP25,SLC2A4RG,JADE1,HCFC1R1,CEP55,WASHC3,LHFPL6,NES,LXN,MCUB,ANO1,BAALC,MAN1C1,FHOD3,DDX60,OPN3,BCL7C,WWOX,TIPIN,RNF128,DOCK10,TRPV2,C3orf14,PDGFD,AK5,CNTNAP1,SCARA3,NXN,COPZ2,SYNE3,RWDD1,TMEM35A,FGD6,TAC3,KCNN2,VGLL3,RGS17,CORIN,LIMS2,PSAT1,STXBP6,LBH,WNT5B,COTL1,MAP3K7CL,SH3BGRL3,SYNC,EIF4EBP1,KCNMA1,CORO1C,COL5A2,COL5A2,UGCG,ADGRA2,EHD2,RARRES1,MCM4,CLU,SPATS2L,EHD1,SH3BP4,,NREP,JPT1,CORO1C,BACE2,WDR41,STMN3,ZNF703,LIMD1,BAALC,THSD4,PDGFD,PSAT1,GASK1B,PARP9,UACA,NTN4,NUF2,ABI3BP,PKIB,AS3MT,LTBP2,GPC6,MGARP,KCNMB2,,SCARA3,USP44,PBOV1,TMTC1,CDCA7,NIPSNAP3A,CXXC5,TIMP2,COTL1,ACTB,ERRFI1,ANKRD13A,MYLK,UGCG,CAMK2D,APCDD1,CAMK2D,SIPA1L2,UTRN,C12orf75,SESN3,POGLUT3,ARHGAP18,CCDC80,CCDC80,TRAPPC1,VSIR,TSPAN5,DTX3L,SYTL2,GPRC5B,RPL22L1,SLC66A3,UHRF1,CTHRC1,CDC42EP3,SKA2,SYNPO2,MSRB3,PXK,JAZF1,CYTOR,JAZF1,JADE1,JADE1,MMP24OS,NIPAL3,SYNPO2,IRAG1,PRICKLE1,PRICKLE1,PPM1M,MAP1B,JDP2,PRSS23,ATP8B1,HSPB6,ADAMTS2,SPTBN1,CHML,TCEA3,TPT1-AS1,VAT1L,MECOM,RASSF4,RNF115,THSD4,SLC9A7,SAMD9L,SNTB2,IFIT2,TENT5C,SSPN,RGMB,SGMS2,GPC6,CCDC80,PDE5A,LOXL4,RASSF3,AFF3,HELLS,FAM171B,TMEM200B,VGLL3,NFIX,EPHA4,CNKSR3,CMBL,MAGI2-AS3,EPG5,SYNPO2,MRGPRF,TNFRSF19,EVA1A,CDC42EP5,TRNP1,LIN7A,IL17RD,ABHD12,PLEKHG4,,CAMK2N1,CLDN11,SIX1,ALPK2,SCUBE3,EPG5,,GALNT15,SCN7A,TMTC2,NALCN,XAF1,PEAR1,RUNX1T1,NUDT7,,DIAPH3,SLC14A1,SCN9A,COL1A2,CD44,MIR155HG,GALNT5,NRXN3,SPX,CCN4,CNTN3,PAK1,IRAG1,HIC1,ZNF469,STXBP6,PRICKLE1,SGCD,FRMD5,,,BEND6,,,FCRL5,CAMK2D,,ROR1,RSBN1L,LOXL1-AS1,SYTL2,KRTAP1-5,PRKAG2,,CXXC5,PRAG1,TOX-DT,MAGI2-AS3,,FBN1,SPOCD1,RHOJ,DUBR,BRIP1,ADAMTS8,TSLP,TMTC2,CCN4,PRSS35,GALNT5,,GALNT15,ANO4,DPF3,NFE2L3,LARP6,HOXB-AS3,ADAMTS2,ELOVL2-AS1,KCTD16,CHEK1,FZD2,,DPF3,DENND1B,UACA,RHOJ,FOXC2,CORIN,PDE5A,TMEM171,,APOL6,LPP,,BMPER,,LMO7,SBF2-AS1,FOXL1,RHOJ,CCDC80,HACD4,HIVEP3,MINDY2,AQP3,FMO3,ARRB1,EHD2,HCFC1R1 FOUNDER_NAMES