STANDARD_NAME	CHOI_ATL_STAGE_PREDICTOR
SYSTEMATIC_NAME	M7507
COLLECTION	C2:CGP
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/CHOI_ATL_STAGE_PREDICTOR
NAMESPACE	AFFY_HG_U133
DESCRIPTION_BRIEF	Genes used to predict the clinical stages of acute T-cell leukemia (ATL): chronic vs acute.
DESCRIPTION_FULL	Adult T-cell leukemia (ATL) is an intractable malignancy of CD4+ T cells that is etiologically associated with infection by human T-cell leukemia virus-type I. Most individuals in the chronic stage of ATL eventually undergo progression to a highly aggressive acute stage. To clarify the mechanism responsible for this stage progression, we isolated CD4+ cells from individuals in the chronic (n=19) or acute (n=22) stages of ATL and subjected them to profiling of gene expression with DNA microarrays containing >44,000 probe sets. Changes in chromosome copy number were also examined for 24 cell specimens with the use of microarrays harboring approximately 50,000 probe sets. Stage-dependent changes in gene expression profile and chromosome copy number were apparent. Furthermore, expression of the gene for MET, a receptor tyrosine kinase for hepatocyte growth factor (HGF), was shown to be specific to the acute stage of ATL, and the plasma concentration of HGF was increased in individuals in either the acute or chronic stage. HGF induced proliferation of a MET-positive ATL cell line, and this effect was blocked by antibodies to HGF. The HGF-MET signaling pathway is thus a potential therapeutic target for ATL.
PMID	16909099
GEOID	GSE1466
AUTHORS	Choi YL,Tsukasaki K,O'Neill MC,Yamada Y,Onimaru Y,Matsumoto K,Ohashi J,Yamashita Y,Tsutsumi S,Kaneda R,Takada S,Aburatani H,Kamihira S,Nakamura T,Tomonaga M,Mano H
CONTRIBUTOR	Leona Saunders
CONTRIBUTOR_ORG	MSigDB Team
EXACT_SOURCE	Table 3S
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	200020_at,200910_at,201310_s_at,201493_s_at,201519_at,201583_s_at,202096_s_at,202127_at,202313_at,202544_at,202754_at,203097_s_at,205707_at,207812_s_at,208667_s_at,208754_s_at,208815_x_at,208956_x_at,210371_s_at,212199_at,212371_at,212519_at,212788_x_at,213738_s_at,216274_s_at,217957_at,218048_at,218088_s_at,218140_x_at,218288_s_at,218290_at,218735_s_at,220147_s_at,220560_at,220952_s_at,223047_at,223741_s_at,224376_s_at,224880_at,225215_s_at,225534_at,226831_at,241843_at,34210_at
GENE_SYMBOLS	TARDBP,CCT3,NREP,PUM2,TOMM70,SEC23B,TSPO,PRP4K,PPP2R2A,GMFB,R3HDM1,RAPGEF2,IL17RA,GORASP2,ST13,NAP1L1,HSPA4,DUT,RBBP4,MRFAP1L1,DESI2,UBE2E1,FTL,ATP5F1A,SEC11A,CFAP20,COMMD3,RRAGC,SRPRB,CCDC90B,PLEKHJ1,ZNF544,SINHCAF,C11orf21,PLEKHA5,CMTM6,TTYH2,RAB5IF,RALA,MTRF1L,SMIM19,SLC25A46,EIF5,CD52
FOUNDER_NAMES