STANDARD_NAME	CORRADETTI_MTOR_PATHWAY_REGULATORS_DN
SYSTEMATIC_NAME	M1146
COLLECTION	ARCHIVED:C2_CGP
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/CORRADETTI_MTOR_PATHWAY_REGULATORS_DN
NAMESPACE	MOUSE_GENE_SYMBOL
DESCRIPTION_BRIEF	Major antagonists linked to the mTOR [GeneID=2475] signaling network.
DESCRIPTION_FULL	The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that controls many aspects of cellular physiology, including transcription, translation, cell size, cytoskeletal organization and autophagy. Recent advances in the mTOR signaling field have found that mTOR exists in two heteromeric complexes, mTORC1 and mTORC2. The activity of mTORC1 is regulated by the integration of many signals, including growth factors, insulin, nutrients, energy availability and cellular stressors such as hypoxia, osmotic stress, reactive oxygen species and viral infection. In this review we highlight recent advances in the mTOR signaling field that relate to how the two mTOR complexes are regulated, and we discuss stress conditions linked to the mTOR signaling network that have not been extensively covered in other reviews. Given the diversity of signals that have been shown to impinge on mTOR, we also speculate on other signal-transduction pathways that may be linked to mTOR in the future.
PMID	17041621
GEOID	
AUTHORS	Corradetti MN,Guan KL
CONTRIBUTOR	Leona Saunders
CONTRIBUTOR_ORG	MSigDB Team
EXACT_SOURCE	Table 1: mTOR activation down
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	AMPK,HIF-1,LKB1,p53,Raptor,Redd1,Rheb,RTP801
GENE_SYMBOLS	,,,,,,RHEB,TP53
FOUNDER_NAMES