STANDARD_NAME CYCLIN_D1_KE_.V1_DN SYSTEMATIC_NAME M2647 COLLECTION C6 MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/CYCLIN_D1_KE_.V1_DN NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes down-regulated in MCF-7 cells (breast cancer) over-expressing a mutant K112E form of CCND1 [Gene ID=595] gene. DESCRIPTION_FULL Here we describe how patterns of gene expression in human tumors have been deconvoluted to reveal a mechanism of action for the cyclin D1 oncogene. Computational analysis of the expression patterns of thousands of genes across hundreds of tumor specimens suggested that a transcription factor, C/EBPbeta/Nf-Il6, participates in the consequences of cyclin D1 overexpression. Functional analyses confirmed the involvement of C/EBPbeta in the regulation of genes affected by cyclin D1 and established this protein as an indispensable effector of a potentially important facet of cyclin D1 biology. This work demonstrates that tumor gene expression databases can be used to study the function of a human oncogene in situ. PMID 12914697 GEOID AUTHORS Lamb J,Ramaswamy S,Ford HL,Contreras B,Martinez RV,Kittrell FS,Zahnow CA,Patterson N,Golub TR,Ewen ME CONTRIBUTOR Pablo Tamayo CONTRIBUTOR_ORG Broad Institute EXACT_SOURCE cyclin D1 (K112E) vs control; bottom 200 genes (diff-means) FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS A2M,ABO,ACTC1,ACTN2,ADARB1,ADD3,ADH1B,AKAP6,ALDH1A1,ALK,ALPL,ALPPL2,AMHR2,ANGPT1,ARL4A,ARNT,ATF2,ATF7,ATP2B3,ATP6V1B1,BAG1,BET1,BNIP2,C10orf116,C15orf31,C1QB,C1R /// LOC643676,C4orf6,CAMK4,CAPG,CATR1,CAV1,CD14,CD37,CD53,CFB,CFTR,CHD8,CHRNB2,CNGB1,COG2,COL3A1,CPA3,CPN1,CRISP2,CRMP1,CSF2,CXCL12,CXCL3,CXCR7,CYP11B1 /// CYP11B2,CYP24A1,CYP2C9,CYP2F1,DAO,DAZ1 /// DAZ3 /// DA,DAZL,DIO2,DNAH3,DNAJB4,DNM1L,DPF1,DRD4,DSG1,EML1,EPHA1,ERBB2,EYA1,F3,FBP2,FCER2,FES,FKBP3,FLT1,FXR2,GAB1,GALT,GART,GATA1,GJA1,GNAZ,GPSM3,GRIA1,GRIN2B,GYPA,GYPB /// GYPE,GYPC,HLA-DRB1 /// HLA-DRB,HPN,HPX,HRG,IFIT3,IFNA10,IFNAR1,IL17A,IL1R1,IL7R,ILF3,INHBB,KCNJ8,KIAA0040,KIAA0141,KIAA0179,KIF1A,KLF9,KLK3,KRT13,KRT17,KRT5,LILRB4,LIMS1,LOC644099,LOC646182,LRMP,MAG,MAPK4,MATK,MC1R,MPI,MS4A1,MX1,MXI1,MYH2,MYL5,MYO1F,NCKAP1L,NEDD4,NELL1,NKX3-1,NNT,NOS1,NPAS1,NR6A1,NTF5,NTSR1,OXT,PAFAH1B3,PBX2,PCK1,PCP4,PDCD2,PDE6H,PDYN,PENK,PEPD,PGM5,PIK3R1,PIP5K2A,PIP5K2B,PLCG2,PNLIPRP1,POU2F2,POU3F1,PPIG,PRKCQ,PRKG2,PROC,PRSS1 /// PRSS2 ///,PSG3,PSME4,PTCRA,PTHR1,PVALB,RAB5B,RAPGEF5,RIT2,RLBP1,RNASE6,ROS1,RXRG,SALL2,SERPINA7,SLC25A11,SMCP,SOX3,SPIB,SPTLC2,TARBP2,TAZ,TCEA2,TCIRG1,TESK1,TFCP2,TGM3,TMSL8,TNFRSF7,TNNT3,TOB2,TUBA1,TUBA3,TXLNA,UBE3A,UCP2,UNG2,VAMP2,VCAM1,WTAP,YLPM1,ZNF132,ZNF35 GENE_SYMBOLS A2M,ABO,ACTC1,ACTN2,ADARB1,ADD3,ADH1B,AKAP6,ALDH1A1,ALK,ALPL,ALPG,AMHR2,ANGPT1,ARL4A,ARNT,ATF2,ATF7,ATP2B3,ATP6V1B1,BAG1,BET1,BNIP2,ADIRF,,C1QB,,LINC01587,CAMK4,CAPG,,CAV1,CD14,CD37,CD53,CFB,CFTR,CHD8,CHRNB2,CNGB1,COG2,COL3A1,CPA3,CPN1,CRISP2,CRMP1,CSF2,CXCL12,CXCL3,ACKR3,,CYP24A1,CYP2C9,CYP2F1,DAO,,DAZL,DIO2,DNAH3,DNAJB4,DNM1L,DPF1,DRD4,DSG1,EML1,EPHA1,ERBB2,EYA1,F3,FBP2,FCER2,FES,FKBP3,FLT1,FXR2,GAB1,GALT,GART,GATA1,GJA1,GNAZ,GPSM3,GRIA1,GRIN2B,GYPA,,GYPC,,HPN,HPX,HRG,IFIT3,IFNA10,IFNAR1,IL17A,IL1R1,IL7R,ILF3,INHBB,KCNJ8,KIAA0040,DELE1,RRP1B,KIF1A,KLF9,KLK3,KRT13,KRT17,KRT5,LILRB4,LIMS1,,XGY2,IRAG2,MAG,MAPK4,MATK,MC1R,MPI,MS4A1,MX1,MXI1,MYH2,MYL5,MYO1F,NCKAP1L,NEDD4,NELL1,NKX3-1,NNT,NOS1,NPAS1,NR6A1,NTF4,NTSR1,OXT,PAFAH1B3,PBX2,PCK1,PCP4,PDCD2,PDE6H,PDYN,PENK,PEPD,PGM5,PIK3R1,PIP4K2A,PIP4K2B,PLCG2,PNLIPRP1,POU2F2,POU3F1,PPIG,PRKCQ,PRKG2,PROC,,PSG3,PSME4,PTCRA,PTH1R,PVALB,RAB5B,RAPGEF5,RIT2,RLBP1,RNASE6,ROS1,RXRG,SALL2,SERPINA7,SLC25A11,SMCP,SOX3,SPIB,SPTLC2,TARBP2,TAFAZZIN,TCEA2,TCIRG1,TESK1,TFCP2,TGM3,TMSB15A,CD27,TNNT3,TOB2,TUBA4A,TUBA1A,TXLNA,UBE3A,UCP2,UNG,VAMP2,VCAM1,WTAP,YLPM1,ZNF132,ZNF35 FOUNDER_NAMES