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<MSIGDB BUILD_DATE="Jan 29, 2026" VERSION="2026.1.Hs" NAME="export">
    <GENESET STANDARD_NAME="CYCLIN_D1_KE_.V1_DN" SYSTEMATIC_NAME="M2647" HISTORICAL_NAMES="" PMID="12914697" AUTHORS="Lamb J,Ramaswamy S,Ford HL,Contreras B,Martinez RV,Kittrell FS,Zahnow CA,Patterson N,Golub TR,Ewen ME" GEOID="" EXACT_SOURCE="cyclin D1 (K112E) vs control; bottom 200 genes (diff-means)" GENESET_LISTING_URL="" EXTERNAL_DETAILS_URL="" CHIP="HUMAN_GENE_SYMBOL" CONTRIBUTOR="Pablo Tamayo" CONTRIBUTOR_ORG="Broad Institute" DESCRIPTION_BRIEF="Genes down-regulated in MCF-7 cells (breast cancer) over-expressing a mutant K112E form of CCND1 [Gene ID=595] gene." DESCRIPTION_FULL="Here we describe how patterns of gene expression in human tumors have been deconvoluted to reveal a mechanism of action for the cyclin D1 oncogene. Computational analysis of the expression patterns of thousands of genes across hundreds of tumor specimens suggested that a transcription factor, C/EBPbeta/Nf-Il6, participates in the consequences of cyclin D1 overexpression. Functional analyses confirmed the involvement of C/EBPbeta in the regulation of genes affected by cyclin D1 and established this protein as an indispensable effector of a potentially important facet of cyclin D1 biology. This work demonstrates that tumor gene expression databases can be used to study the function of a human oncogene in situ." TAGS="" MEMBERS="A2M,ABO,ACTC1,ACTN2,ADARB1,ADD3,ADH1B,AKAP6,ALDH1A1,ALK,ALPL,ALPPL2,AMHR2,ANGPT1,ARL4A,ARNT,ATF2,ATF7,ATP2B3,ATP6V1B1,BAG1,BET1,BNIP2,C10orf116,C15orf31,C1QB,C1R /// LOC643676,C4orf6,CAMK4,CAPG,CATR1,CAV1,CD14,CD37,CD53,CFB,CFTR,CHD8,CHRNB2,CNGB1,COG2,COL3A1,CPA3,CPN1,CRISP2,CRMP1,CSF2,CXCL12,CXCL3,CXCR7,CYP11B1 /// CYP11B2,CYP24A1,CYP2C9,CYP2F1,DAO,DAZ1 /// DAZ3 /// DA,DAZL,DIO2,DNAH3,DNAJB4,DNM1L,DPF1,DRD4,DSG1,EML1,EPHA1,ERBB2,EYA1,F3,FBP2,FCER2,FES,FKBP3,FLT1,FXR2,GAB1,GALT,GART,GATA1,GJA1,GNAZ,GPSM3,GRIA1,GRIN2B,GYPA,GYPB /// GYPE,GYPC,HLA-DRB1 /// HLA-DRB,HPN,HPX,HRG,IFIT3,IFNA10,IFNAR1,IL17A,IL1R1,IL7R,ILF3,INHBB,KCNJ8,KIAA0040,KIAA0141,KIAA0179,KIF1A,KLF9,KLK3,KRT13,KRT17,KRT5,LILRB4,LIMS1,LOC644099,LOC646182,LRMP,MAG,MAPK4,MATK,MC1R,MPI,MS4A1,MX1,MXI1,MYH2,MYL5,MYO1F,NCKAP1L,NEDD4,NELL1,NKX3-1,NNT,NOS1,NPAS1,NR6A1,NTF5,NTSR1,OXT,PAFAH1B3,PBX2,PCK1,PCP4,PDCD2,PDE6H,PDYN,PENK,PEPD,PGM5,PIK3R1,PIP5K2A,PIP5K2B,PLCG2,PNLIPRP1,POU2F2,POU3F1,PPIG,PRKCQ,PRKG2,PROC,PRSS1 /// PRSS2 ///,PSG3,PSME4,PTCRA,PTHR1,PVALB,RAB5B,RAPGEF5,RIT2,RLBP1,RNASE6,ROS1,RXRG,SALL2,SERPINA7,SLC25A11,SMCP,SOX3,SPIB,SPTLC2,TARBP2,TAZ,TCEA2,TCIRG1,TESK1,TFCP2,TGM3,TMSL8,TNFRSF7,TNNT3,TOB2,TUBA1,TUBA3,TXLNA,UBE3A,UCP2,UNG2,VAMP2,VCAM1,WTAP,YLPM1,ZNF132,ZNF35" MEMBERS_SYMBOLIZED="A2M,ABO,ACKR3,ACTC1,ACTN2,ADARB1,ADD3,ADH1B,ADIRF,AKAP6,ALDH1A1,ALK,ALPG,ALPL,AMHR2,ANGPT1,ARL4A,ARNT,ATF2,ATF7,ATP2B3,ATP6V1B1,BAG1,BET1,BNIP2,C1QB,CAMK4,CAPG,CAV1,CD14,CD27,CD37,CD53,CFB,CFTR,CHD8,CHRNB2,CNGB1,COG2,COL3A1,CPA3,CPN1,CRISP2,CRMP1,CSF2,CXCL12,CXCL3,CYP24A1,CYP2C9,CYP2F1,DAO,DAZL,DELE1,DIO2,DNAH3,DNAJB4,DNM1L,DPF1,DRD4,DSG1,EML1,EPHA1,ERBB2,EYA1,F3,FBP2,FCER2,FES,FKBP3,FLT1,FXR2,GAB1,GALT,GART,GATA1,GJA1,GNAZ,GPSM3,GRIA1,GRIN2B,GYPA,GYPC,HPN,HPX,HRG,IFIT3,IFNA10,IFNAR1,IL17A,IL1R1,IL7R,ILF3,INHBB,IRAG2,KCNJ8,KIAA0040,KIF1A,KLF9,KLK3,KRT13,KRT17,KRT5,LILRB4,LIMS1,LINC01587,MAG,MAPK4,MATK,MC1R,MPI,MS4A1,MX1,MXI1,MYH2,MYL5,MYO1F,NCKAP1L,NEDD4,NELL1,NKX3-1,NNT,NOS1,NPAS1,NR6A1,NTF4,NTSR1,OXT,PAFAH1B3,PBX2,PCK1,PCP4,PDCD2,PDE6H,PDYN,PENK,PEPD,PGM5,PIK3R1,PIP4K2A,PIP4K2B,PLCG2,PNLIPRP1,POU2F2,POU3F1,PPIG,PRKCQ,PRKG2,PROC,PSG3,PSME4,PTCRA,PTH1R,PVALB,RAB5B,RAPGEF5,RIT2,RLBP1,RNASE6,ROS1,RRP1B,RXRG,SALL2,SERPINA7,SLC25A11,SMCP,SOX3,SPIB,SPTLC2,TAFAZZIN,TARBP2,TCEA2,TCIRG1,TESK1,TFCP2,TGM3,TMSB15A,TNNT3,TOB2,TUBA1A,TUBA4A,TXLNA,UBE3A,UCP2,UNG,VAMP2,VCAM1,WTAP,XGY2,YLPM1,ZNF132,ZNF35" MEMBERS_EZID="100132596,10059,10124,10141,10282,10312,104,10766,1080,10974,11006,11013,11016,11080,1141,120,125,1258,1281,1359,1369,1386,1400,1437,1559,1572,1591,1610,1618,171558,1734,1815,1828,2,200081,2009,2041,2064,2138,2152,216,2208,2242,22796,2287,23076,23198,2321,23530,238,249,251,2549,2592,2618,2623,2649,269,2697,2781,28,284,2890,2904,2921,2993,2995,3071,3249,3263,3273,3437,3446,3454,354,3554,3575,3605,3609,3625,3764,3852,3860,3872,3987,4033,405,4099,4145,4157,4184,4351,4542,4599,4601,4620,4636,4734,4745,4824,4842,4861,4909,492,4923,5020,5050,5089,5105,5121,5134,5149,5173,5179,5184,5239,525,5295,5305,5336,5407,5452,5453,547,55567,5588,5593,5596,5624,56252,5671,57007,573,5745,57680,5816,5869,6014,6017,6039,6098,6258,629,6297,6387,63940,663,6658,6689,6844,687,6895,6901,6906,6919,70,7016,7024,7053,713,7140,7180,7277,7337,7351,7374,7412,7584,7691,7846,814,8193,822,8396,8402,857,8789,88,929,931,9360,939,9472,951,9513,9517,9589,963,9674,9771,9812" MEMBERS_MAPPING="A2M,A2M,2|ABO,ABO,28|ACTC1,ACTC1,70|ACTN2,ACTN2,88|ADARB1,ADARB1,104|ADD3,ADD3,120|ADH1B,ADH1B,125|AKAP6,AKAP6,9472|ALDH1A1,ALDH1A1,216|ALK,ALK,238|ALPL,ALPL,249|ALPPL2,ALPG,251|AMHR2,AMHR2,269|ANGPT1,ANGPT1,284|ARL4A,ARL4A,10124|ARNT,ARNT,405|ATF2,ATF2,1386|ATF7,ATF7,11016|ATP2B3,ATP2B3,492|ATP6V1B1,ATP6V1B1,525|BAG1,BAG1,573|BET1,BET1,10282|BNIP2,BNIP2,663|C10orf116,ADIRF,10974|C15orf31,null,null|C1QB,C1QB,713|C1R /// LOC643676,null,null|C4orf6,LINC01587,10141|CAMK4,CAMK4,814|CAPG,CAPG,822|CATR1,null,null|CAV1,CAV1,857|CD14,CD14,929|CD37,CD37,951|CD53,CD53,963|CFB,CFB,629|CFTR,CFTR,1080|CHD8,CHD8,57680|CHRNB2,CHRNB2,1141|CNGB1,CNGB1,1258|COG2,COG2,22796|COL3A1,COL3A1,1281|CPA3,CPA3,1359|CPN1,CPN1,1369|CRISP2,CRISP2,7180|CRMP1,CRMP1,1400|CSF2,CSF2,1437|CXCL12,CXCL12,6387|CXCL3,CXCL3,2921|CXCR7,ACKR3,57007|CYP11B1 /// CYP11B2,null,null|CYP24A1,CYP24A1,1591|CYP2C9,CYP2C9,1559|CYP2F1,CYP2F1,1572|DAO,DAO,1610|DAZ1 /// DAZ3 /// DA,null,null|DAZL,DAZL,1618|DIO2,DIO2,1734|DNAH3,DNAH3,55567|DNAJB4,DNAJB4,11080|DNM1L,DNM1L,10059|DPF1,DPF1,8193|DRD4,DRD4,1815|DSG1,DSG1,1828|EML1,EML1,2009|EPHA1,EPHA1,2041|ERBB2,ERBB2,2064|EYA1,EYA1,2138|F3,F3,2152|FBP2,FBP2,8789|FCER2,FCER2,2208|FES,FES,2242|FKBP3,FKBP3,2287|FLT1,FLT1,2321|FXR2,FXR2,9513|GAB1,GAB1,2549|GALT,GALT,2592|GART,GART,2618|GATA1,GATA1,2623|GJA1,GJA1,2697|GNAZ,GNAZ,2781|GPSM3,GPSM3,63940|GRIA1,GRIA1,2890|GRIN2B,GRIN2B,2904|GYPA,GYPA,2993|GYPB /// GYPE,null,null|GYPC,GYPC,2995|HLA-DRB1 /// HLA-DRB,null,null|HPN,HPN,3249|HPX,HPX,3263|HRG,HRG,3273|IFIT3,IFIT3,3437|IFNA10,IFNA10,3446|IFNAR1,IFNAR1,3454|IL17A,IL17A,3605|IL1R1,IL1R1,3554|IL7R,IL7R,3575|ILF3,ILF3,3609|INHBB,INHBB,3625|KCNJ8,KCNJ8,3764|KIAA0040,KIAA0040,9674|KIAA0141,DELE1,9812|KIAA0179,RRP1B,23076|KIF1A,KIF1A,547|KLF9,KLF9,687|KLK3,KLK3,354|KRT13,KRT13,3860|KRT17,KRT17,3872|KRT5,KRT5,3852|LILRB4,LILRB4,11006|LIMS1,LIMS1,3987|LOC644099,null,null|LOC646182,XGY2,100132596|LRMP,IRAG2,4033|MAG,MAG,4099|MAPK4,MAPK4,5596|MATK,MATK,4145|MC1R,MC1R,4157|MPI,MPI,4351|MS4A1,MS4A1,931|MX1,MX1,4599|MXI1,MXI1,4601|MYH2,MYH2,4620|MYL5,MYL5,4636|MYO1F,MYO1F,4542|NCKAP1L,NCKAP1L,3071|NEDD4,NEDD4,4734|NELL1,NELL1,4745|NKX3-1,NKX3-1,4824|NNT,NNT,23530|NOS1,NOS1,4842|NPAS1,NPAS1,4861|NR6A1,NR6A1,2649|NTF5,NTF4,4909|NTSR1,NTSR1,4923|OXT,OXT,5020|PAFAH1B3,PAFAH1B3,5050|PBX2,PBX2,5089|PCK1,PCK1,5105|PCP4,PCP4,5121|PDCD2,PDCD2,5134|PDE6H,PDE6H,5149|PDYN,PDYN,5173|PENK,PENK,5179|PEPD,PEPD,5184|PGM5,PGM5,5239|PIK3R1,PIK3R1,5295|PIP5K2A,PIP4K2A,5305|PIP5K2B,PIP4K2B,8396|PLCG2,PLCG2,5336|PNLIPRP1,PNLIPRP1,5407|POU2F2,POU2F2,5452|POU3F1,POU3F1,5453|PPIG,PPIG,9360|PRKCQ,PRKCQ,5588|PRKG2,PRKG2,5593|PROC,PROC,5624|PRSS1 /// PRSS2 ///,null,null|PSG3,PSG3,5671|PSME4,PSME4,23198|PTCRA,PTCRA,171558|PTHR1,PTH1R,5745|PVALB,PVALB,5816|RAB5B,RAB5B,5869|RAPGEF5,RAPGEF5,9771|RIT2,RIT2,6014|RLBP1,RLBP1,6017|RNASE6,RNASE6,6039|ROS1,ROS1,6098|RXRG,RXRG,6258|SALL2,SALL2,6297|SERPINA7,SERPINA7,6906|SLC25A11,SLC25A11,8402|SMCP,SMCP,4184|SOX3,SOX3,6658|SPIB,SPIB,6689|SPTLC2,SPTLC2,9517|TARBP2,TARBP2,6895|TAZ,TAFAZZIN,6901|TCEA2,TCEA2,6919|TCIRG1,TCIRG1,10312|TESK1,TESK1,7016|TFCP2,TFCP2,7024|TGM3,TGM3,7053|TMSL8,TMSB15A,11013|TNFRSF7,CD27,939|TNNT3,TNNT3,7140|TOB2,TOB2,10766|TUBA1,TUBA4A,7277|TUBA3,TUBA1A,7846|TXLNA,TXLNA,200081|UBE3A,UBE3A,7337|UCP2,UCP2,7351|UNG2,UNG,7374|VAMP2,VAMP2,6844|VCAM1,VCAM1,7412|WTAP,WTAP,9589|YLPM1,YLPM1,56252|ZNF132,ZNF132,7691|ZNF35,ZNF35,7584" FILTERED_BY_SIMILARITY="" FOUNDER_NAMES="" REFINEMENT_DATASETS="" VALIDATION_DATASETS="" CATEGORY_CODE="C6" ORGANISM="Homo sapiens" SUB_CATEGORY_CODE=""/>
</MSIGDB>
