STANDARD_NAME DCA_UP.V1_DN SYSTEMATIC_NAME M2760 COLLECTION C6 MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/DCA_UP.V1_DN NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes down-regulated in A549 lung carcinoma and M059K glioblastoma cells treated with dichloroacetate [PubChem=6597]. DESCRIPTION_FULL Analysis of A549 lung carcinoma and M059K glioblastoma cells treated with dichloroacetate (DCA), an inhibitor of the mitochondrial pyruvate dehydrogenase kinase. DCA shifts metabolism from glycolysis to glucose oxidation and decreases mitochondrial membrane potential in cancer cells. PMID 17222789 GEOID GSE6014 AUTHORS Bonnet S,Archer SL,Allalunis-Turner J,Haromy A,Beaulieu C,Thompson R,Lee CT,Lopaschuk GD,Puttagunta L,Bonnet S,Harry G,Hashimoto K,Porter CJ,Andrade MA,Thebaud B,Michelakis ED CONTRIBUTOR Pablo Tamayo CONTRIBUTOR_ORG Broad Institute EXACT_SOURCE DCA vs Controls; bottom 200 genes (diff. of means) FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS ABCA5,ACCN4,ACIN1,ADM2,AGXT2L1,ALK,ANAPC10,ANKRD2,ANKRD46,ARHGAP15,ARHGEF9,ASPM,ATP10D,BTBD14B,C10orf12,C10orf56,C10orf84,C11orf61,C15orf29,C17orf63,C19orf28,C1orf109,C1orf135,C1orf89,C2orf18,C2orf37,C3orf9,C7orf16,C9orf39,CA5A,CACNA1S,CDH16,CDK10,CDK5R2,CDON,CENTG1,CHEK2,CHST2,CLIC5,CNNM4,COL21A1,CPB2,CRSP3,CST7,CTAG2,CX3CL1,DGAT1 /// LOC642255,DHX35,DHX57,DIP,ENO3,FGF9,FGR,FLJ10038,FUT3,GALR3,GMPR,GPR116,GPR137B,GPR19,GPT,GRID2,GSDMDC1,HIST1H3D,HR44,HSPC049,IFNA5,IFNG,IGLJ3,IHPK2,IL10RA,INSL5,IRAK4,IRF2BP1,JOSD1,KCTD3,KIAA0894,KIAA1856,KLHL1,KRT1,KRT24,KRT5,LAMA3,LAT,LIN7B,LOC153561 /// LOC643,LOC339047,LOC474170,LOC55565,LOC643326,LOC643328,LOC646541,LOC653326,LOC93349,LONPL,LRP5L,LRRC14,MAGEB3,MAGEH1,MAP3K14,MARCH2,MATN4,MCTP1,MFGE8,MGC2889,MGC61571,MGC87042,MNAT1,MSH5,MTRF1,MYLC2PL,NFASC,NOL8,NOTCH2NL,NPIP,NPIP /// LOC23117 //,NR4A1,NR5A1,NUDT11,NUMB,NUP62,NXF2,OR11A1,PDE6A,PDK2,PES1,PEX19,PHC1 /// LOC653441,PHKG2,PIN1,PIP3-E,PKD1,PKP1,PLA2G4C,PLK3,POR,PPCDC,PPP1R12B,PPP1R13B,PRPF38B,PRRX2,PTPRG,RAB11FIP1,RALGDS,RASSF4,RBM14,RNPEPL1,RP11-298P3.3,RRP22,RS1,S100A14,SERPINB3,SETBP1,SETD4,SHMT1,SHOX2,SIAH2,SIRPB1,SKIL,SLC16A10,SLC22A17,SLC29A3,SLC38A3,SLC6A6,SLC7A9,SNCB,SNX24,SPBC25,SPRR1A,STAG3,STARD3,TAF1C,TBX6,TCIRG1,TCL1A,TCL1B,TDRD7,TG,TGFBRAP1,TMEM115,TMEM24,TNFRSF10C /// MGC319,TNFSF18,TNRC21,TRIM52,TRPM6,TXLNA,UPK1A,VPS52,WDSOF1,YIPF3,ZAK,ZFX /// ZFY,ZNF248,ZNF286,ZNF307,ZNF32,ZNF652,ZNF84,ZXDA /// ZXDB GENE_SYMBOLS ABCA5,ASIC4,ACIN1,ADM2,ETNPPL,ALK,ANAPC10,ANKRD2,ANKRD46,ARHGAP15,ARHGEF9,ASPM,ATP10D,NACC1,LCOR,ZCCHC24,FAM204A,MSANTD2,KATNBL1,FAM222B,MFSD12,C1orf109,AUNIP,CPLANE2,SLC35F6,DCAF17,POGLUT1,PPP1R17,CNTLN,CA5A,CACNA1S,CDH16,CDK10,CDK5R2,CDON,AGAP2,CHEK2,CHST2,CLIC5,CNNM4,COL21A1,CPB2,MED23,CST7,CTAG2,CX3CL1,,DHX35,DHX57,TSC22D3,ENO3,FGF9,FGR,GABPB1-IT1,FUT3,GALR3,GMPR,ADGRF5,GPR137B,GPR19,GPT,GRID2,GSDMD,H3C4,,WDR91,IFNA5,IFNG,IGLJ3,IP6K2,IL10RA,INSL5,IRAK4,IRF2BP1,JOSD1,KCTD3,,TNRC18,KLHL1,KRT1,KRT24,KRT5,LAMA3,LAT,LIN7B,,PKD1P1,LRRC37A2,ZNF821,,,,,SP140L,LONP2,LRP5L,LRRC14,MAGEB3,MAGEH1,MAP3K14,MARCHF2,MATN4,MCTP1,MFGE8,,CMC1,STEAP1B,MNAT1,MSH5,MTRF1,MYL10,NFASC,NOL8,NOTCH2NLA,NPIPA1,,NR4A1,NR5A1,NUDT11,NUMB,NUP62,NXF2,OR11A1,PDE6A,PDK2,PES1,PEX19,,PHKG2,PIN1,IPCEF1,PKD1,PKP1,PLA2G4C,PLK3,POR,PPCDC,PPP1R12B,PPP1R13B,PRPF38B,PRRX2,PTPRG,RAB11FIP1,RALGDS,RASSF4,RBM14,RNPEPL1,,RASL10A,RS1,S100A14,SERPINB3,SETBP1,SETD4,SHMT1,SHOX2,SIAH2,SIRPB1,SKIL,SLC16A10,SLC22A17,SLC29A3,SLC38A3,SLC6A6,SLC7A9,SNCB,SNX24,SPC25,SPRR1A,STAG3,STARD3,TAF1C,TBX6,TCIRG1,TCL1A,TCL1B,TDRD7,TG,TGFBRAP1,TMEM115,C2CD2L,,TNFSF18,KMT2D,TRIM52,TRPM6,TXLNA,UPK1A,VPS52,DCAF13,YIPF3,MAP3K20,,ZNF248,ZNF286A,ZKSCAN4,ZNF32,ZNF652,ZNF84, FOUNDER_NAMES