STANDARD_NAME	DEBOSSCHER_NFKB_TARGETS_REPRESSED_BY_GLUCOCORTICOIDS
SYSTEMATIC_NAME	M17340
COLLECTION	C2:CGP
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/DEBOSSCHER_NFKB_TARGETS_REPRESSED_BY_GLUCOCORTICOIDS
NAMESPACE	HUMAN_GENE_SYMBOL
DESCRIPTION_BRIEF	NF-kB-driven pro-inflammatory genes that are  negatively regulated by glucocorticoids.
DESCRIPTION_FULL	A variety of studies have shown that some activated nuclear receptors (NRs), especially the glucorticoid receptor, the estrogen receptor and peroxisome proliferator-activated receptor, can inhibit the activity of the transcription factor nuclear factor kappaB (NF-kappaB), which plays a key role in the control of genes involved in inflammation, cell proliferation and apoptosis. This review describes the molecular mechanisms of cross-talk between NRs and NF-kappaB and the biological relevance of this cross-talk. The importance and mechanistic aspects of selective NR modulation are discussed. Also included are future research prospects, which will lead to a new era in the field of NR research with the aim of specifically inhibiting NF-kappaB-driven gene expression for anti-inflammatory, anti-tumor and immune-modulatory purposes.
PMID	17072333
GEOID	
AUTHORS	De Bosscher K,Vanden Berghe W,Haegeman G
CONTRIBUTOR	Arthur Liberzon
CONTRIBUTOR_ORG	MSigDB Team
EXACT_SOURCE	Table 1
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	CCL13,CINC/gro,COX-2,cPLA2,E-selectin,EDN1,eotaxin,GM-CSF,ICAM,IL-1,IL-11,IL-13,IL-18,IL-2,IL-3,IL-4,IL-5,IL-6,IL-9,IL12A,IL8,iNOS,MIP-1a,RANTES,SCF,TNF-alpha,VCAM1
GENE_SYMBOLS	CCL13,,PTGER2,,EDN1,CSF2,,,IL11,IL13,IL18,IL2,IL3,IL4,IL5,IL6,IL9,IL12A,CXCL8,,CCL5,KITLG,TNF,VCAM1,KAT5,CCL11,NOS2
FOUNDER_NAMES