<?xml version="1.0" encoding="UTF-8" standalone="yes"?>

<!-- Copyright (c) 2004-2026 Broad Institute, Inc., Massachusetts Institute of Technology, and Regents of the University of California.  All rights reserved.
     See license terms at www.gsea-msigdb.org/gsea/license_terms_list. Please note that certain gene sets have special access terms.
-->
<MSIGDB BUILD_DATE="Jan 29, 2026" VERSION="2026.1.Hs" NAME="export">
    <GENESET STANDARD_NAME="DEBOSSCHER_NFKB_TARGETS_REPRESSED_BY_GLUCOCORTICOIDS" SYSTEMATIC_NAME="M17340" HISTORICAL_NAMES="" PMID="17072333" AUTHORS="De Bosscher K,Vanden Berghe W,Haegeman G" GEOID="" EXACT_SOURCE="Table 1" GENESET_LISTING_URL="" EXTERNAL_DETAILS_URL="" CHIP="HUMAN_GENE_SYMBOL" CONTRIBUTOR="Arthur Liberzon" CONTRIBUTOR_ORG="MSigDB Team" DESCRIPTION_BRIEF="NF-kB-driven pro-inflammatory genes that are  negatively regulated by glucocorticoids." DESCRIPTION_FULL="A variety of studies have shown that some activated nuclear receptors (NRs), especially the glucorticoid receptor, the estrogen receptor and peroxisome proliferator-activated receptor, can inhibit the activity of the transcription factor nuclear factor kappaB (NF-kappaB), which plays a key role in the control of genes involved in inflammation, cell proliferation and apoptosis. This review describes the molecular mechanisms of cross-talk between NRs and NF-kappaB and the biological relevance of this cross-talk. The importance and mechanistic aspects of selective NR modulation are discussed. Also included are future research prospects, which will lead to a new era in the field of NR research with the aim of specifically inhibiting NF-kappaB-driven gene expression for anti-inflammatory, anti-tumor and immune-modulatory purposes." TAGS="" MEMBERS="CCL13,CINC/gro,COX-2,cPLA2,E-selectin,EDN1,eotaxin,GM-CSF,ICAM,IL-1,IL-11,IL-13,IL-18,IL-2,IL-3,IL-4,IL-5,IL-6,IL-9,IL12A,IL8,iNOS,MIP-1a,RANTES,SCF,TNF-alpha,VCAM1" MEMBERS_SYMBOLIZED="CCL11,CCL13,CCL5,CSF2,CXCL8,EDN1,IL11,IL12A,IL13,IL18,IL2,IL3,IL4,IL5,IL6,IL9,KAT5,KITLG,NOS2,PTGER2,TNF,VCAM1" MEMBERS_EZID="10524,1437,1906,3558,3562,3565,3567,3569,3576,3578,3589,3592,3596,3606,4254,4843,5732,6352,6356,6357,7124,7412" MEMBERS_MAPPING="CCL13,CCL13,6357|CINC/gro,null,null|COX-2,PTGER2,5732|E-selectin,null,null|EDN1,EDN1,1906|GM-CSF,CSF2,1437|ICAM,null,null|IL-1,null,null|IL-11,IL11,3589|IL-13,IL13,3596|IL-18,IL18,3606|IL-2,IL2,3558|IL-3,IL3,3562|IL-4,IL4,3565|IL-5,IL5,3567|IL-6,IL6,3569|IL-9,IL9,3578|IL12A,IL12A,3592|IL8,CXCL8,3576|MIP-1a,null,null|RANTES,CCL5,6352|SCF,KITLG,4254|TNF-alpha,TNF,7124|VCAM1,VCAM1,7412|cPLA2,KAT5,10524|eotaxin,CCL11,6356|iNOS,NOS2,4843" FILTERED_BY_SIMILARITY="" FOUNDER_NAMES="" REFINEMENT_DATASETS="" VALIDATION_DATASETS="" CATEGORY_CODE="C2" ORGANISM="Homo sapiens" SUB_CATEGORY_CODE="CGP"/>
</MSIGDB>
