STANDARD_NAME	DER_IFN_GAMMA_RESPONSE_DN
SYSTEMATIC_NAME	M8478
COLLECTION	C2:CGP
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/DER_IFN_GAMMA_RESPONSE_DN
NAMESPACE	AFFY_HuGene
DESCRIPTION_BRIEF	Genes down-regulated in HT1080 (fibrosarcoma) cells by treatment with interferon gamma for 6 h.
DESCRIPTION_FULL	The pleiotropic activities of interferons (IFNs) are mediated primarily through the transcriptional regulation of many downstream effector genes. The mRNA profiles from IFN-alpha, -beta, or -gamma treatments of the human fibrosarcoma cell line, HT1080, were determined by using oligonucleotide arrays with probe sets corresponding to more than 6,800 human genes. Among these were transcripts for known IFN-stimulated genes (ISGs), the expression of which were consistent with previous studies in which the particular ISG was characterized as responsive to either Type I (alpha, beta) or Type II (gamma) IFNs, or both. Importantly, many novel IFN-stimulated genes were identified that were diverse in their known biological functions. For instance, several novel ISGs were identified that are implicated in apoptosis (including RAP46/Bag-1, phospholipid scramblase, and hypoxia inducible factor-1alpha). Furthermore, several IFN-repressed genes also were identified. These results demonstrate the usefulness of oligonucleotide arrays in monitoring mammalian gene expression on a broad and unprecedented scale. In particular, these findings provide insights into the basic mechanisms of IFN actions and ultimately may contribute to better therapeutic uses for IFNs.
PMID	9861020
GEOID	
AUTHORS	Der SD,Zhou A,Williams BR,Silverman RH
CONTRIBUTOR	Yujin Hoshida
CONTRIBUTOR_ORG	Broad Institute
EXACT_SOURCE	Table 3: IFN gamma
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	D86971_at,L33243_at,L77701_at,M15841_at,M16706,U07000_cds4_at,U60062_at,U62962_at,U78798_at,X17025_at,X97748_s_at,Z31695_at
GENE_SYMBOLS	LARP4B,PKD1,COX17,SNRPB2,,FBXW4P1,,EIF3E,TRAF6,IDI1,PTX3,INPP5A
FOUNDER_NAMES