STANDARD_NAME	FARMER_BREAST_CANCER_CLUSTER_4
SYSTEMATIC_NAME	M15125
COLLECTION	C2:CGP
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/FARMER_BREAST_CANCER_CLUSTER_4
NAMESPACE	AFFY_HG_U133
DESCRIPTION_BRIEF	Cluster 4: selected stromal genes clustered together across breast cancer samples.
DESCRIPTION_FULL	Previous microarray studies on breast cancer identified multiple tumour classes, of which the most prominent, named luminal and basal, differ in expression of the oestrogen receptor alpha gene (ER). We report here the identification of a group of breast tumours with increased androgen signalling and a 'molecular apocrine' gene expression profile. Tumour samples from 49 patients with large operable or locally advanced breast cancers were tested on Affymetrix U133A gene expression microarrays. Principal components analysis and hierarchical clustering split the tumours into three groups: basal, luminal and a group we call molecular apocrine. All of the molecular apocrine tumours have strong apocrine features on histological examination (P=0.0002). The molecular apocrine group is androgen receptor (AR) positive and contains all of the ER-negative tumours outside the basal group. Kolmogorov-Smirnov testing indicates that oestrogen signalling is most active in the luminal group, and androgen signalling is most active in the molecular apocrine group. ERBB2 amplification is commoner in the molecular apocrine than the other groups. Genes that best split the three groups were identified by Wilcoxon test. Correlation of the average expression profile of these genes in our data with the expression profile of individual tumours in four published breast cancer studies suggest that molecular apocrine tumours represent 8-14% of tumours in these studies. Our data show that it is possible with microarray data to divide mammary tumour cells into three groups based on steroid receptor activity: luminal (ER+ AR+), basal (ER- AR-) and molecular apocrine (ER- AR+).
PMID	15897907
GEOID	GSE1561
AUTHORS	Farmer P,Bonnefoi H,Becette V,Tubiana-Hulin M,Fumoleau P,Larsimont D,Macgrogan G,Bergh J,Cameron D,Goldstein D,Duss S,Nicoulaz AL,Brisken C,Fiche M,Delorenzi M,Iggo R
CONTRIBUTOR	Leona Saunders
CONTRIBUTOR_ORG	MSigDB Team
EXACT_SOURCE	Figure 5S: cluster 4
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	201185_at,201792_at,201852_x_at,202283_at,202404_s_at,202450_s_at,202465_at,202766_s_at,203083_at,204114_at,204135_at,205499_at,207173_x_at,209955_s_at,212488_at,212667_at,213790_at,219179_at,221730_at
GENE_SYMBOLS	HTRA1,AEBP1,COL3A1,SERPINF1,COL1A2,CTSK,PCOLCE,FBN1,THBS2,NID2,FILIP1L,SRPX2,CDH11,FAP,COL5A1,SPARC,ADAM12,DACT1,COL5A2
FOUNDER_NAMES