STANDARD_NAME FIGUEROA_AML_METHYLATION_CLUSTER_1_DN SYSTEMATIC_NAME M2161 COLLECTION C2:CGP MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/FIGUEROA_AML_METHYLATION_CLUSTER_1_DN NAMESPACE HUMAN_SEQ_ACCESSION DESCRIPTION_BRIEF Cluster 1 of aberrantly hypomethylated genes in blasts from AML (acute myeloid leukemia) patients. DESCRIPTION_FULL We hypothesized that DNA methylation distributes into specific patterns in cancer cells, which reflect critical biological differences. We therefore examined the methylation profiles of 344 patients with acute myeloid leukemia (AML). Clustering of these patients by methylation data segregated patients into 16 groups. Five of these groups defined new AML subtypes that shared no other known feature. In addition, DNA methylation profiles segregated patients with CEBPA aberrations from other subtypes of leukemia, defined four epigenetically distinct forms of AML with NPM1 mutations, and showed that established AML1-ETO, CBFb-MYH11, and PML-RARA leukemia entities are associated with specific methylation profiles. We report a 15 gene methylation classifier predictive of overall survival in an independent patient cohort (p < 0.001, adjusted for known covariates). PMID 20060365 GEOID GSE18700 AUTHORS Figueroa ME,Lugthart S,Li Y,Erpelinck-Verschueren C,Deng X,Christos PJ,Schifano E,Booth J,van Putten W,Skrabanek L,Campagne F,Mazumdar M,Greally JM,Valk PJ,Löwenberg B,Delwel R,Melnick A CONTRIBUTOR Arthur Liberzon CONTRIBUTOR_ORG MSigDB Team EXACT_SOURCE Table 3AS: Hypomethylated FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS AA429145,AI253093,AI935123,AK027093,AK056013,AK074231,AK091244,AL035252,AL117578,BC004995,BC024312,BC029496,BC036906,BE551146,BF434539,N66633,NM_000368,NM_001008567,NM_001040059,NM_001059,NM_001083116,NM_001091,NM_001251,NM_001620,NM_001778,NM_002592,NM_002981,NM_003263,NM_003818,NM_005041,NM_005263,NM_006023,NM_006238,NM_014142,NM_014553,NM_014810,NM_015015,NM_015308,NM_018656,NM_021046,NM_021058,NM_021064,NM_021115,NM_021209,NM_022551,NM_022553,NM_024060,NM_025143,NM_080871,NM_138370,NM_145068,NM_178526,NM_181873,NM_207380,U40317 GENE_SYMBOLS RUFY1,,AHNAK2,MARVELD1,LINC00242,MOB3B,DNM1P35,ENTPD6,LRRC3,MARVELD1,MED25,PTPRS,ADPRHL1,,NQO2,LHFPL2,TSC1,TSC1,CD68,TACR3,PRF1,AOC1,CD68,AHNAK,CD48,PCNA,CCL1,TLR1,CDS2,PRF1,GFI1,CDC123,PPARD,NUDT5,TFCP2L1,CEP350,KDM4B,FNBP4,SLC35E3,KRTAP5-8,H2BC11,H2AC11,SEZ6L,NLRC4,RPS18,VPS52,AHNAK,,ASB10,PKDCC,TRPV3,SLC25A42,MTMR11,CCDC9B,PTPRS FOUNDER_NAMES