STANDARD_NAME FRANCO_BLOOD_SANOFI_PASTEUR_SA_INACTIVATED_INFLUENZA_VACCINE_CORRELATED_WITH_ANTIBODY_RESPONSE_AGE_18_40YO_14DY_NEGATIVE SYSTEMATIC_NAME M41090 COLLECTION C7:VAX MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/FRANCO_BLOOD_SANOFI_PASTEUR_SA_INACTIVATED_INFLUENZA_VACCINE_CORRELATED_WITH_ANTIBODY_RESPONSE_AGE_18_40YO_14DY_NEGATIVE NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes negatively correlated with antibody response in blood in adults (18-40) after exposure to Sanofi Pasteur, SA, Inactivated influenza vaccine , time point 14D DESCRIPTION_FULL Identification of the host genetic factors that contribute to variation in vaccine responsiveness may uncover important mechanisms affecting vaccine efficacy. We carried out an integrative, longitudinal study combining genetic, transcriptional, and immunologic data in humans given seasonal influenza vaccine. We identified 20 genes exhibiting a transcriptional response to vaccination, significant genotype effects on gene expression, and correlation between the transcriptional and antibody responses. The results show that variation at the level of genes involved in membrane trafficking and antigen processing significantly influences the human response to influenza vaccination. More broadly, we demonstrate that an integrative study design is an efficient alternative to existing methods for the identification of genes involved in complex traits. DOI:http://dx.doi.org/10.7554/eLife.00299.001. PMID 23878721 GEOID AUTHORS Franco LM,Bucasas KL,Wells JM,NiƱo D,Wang X,Zapata GE,Arden N,Renwick A,Yu P,Quarles JM,Bray MS,Couch RB,Belmont JW,Shaw CA CONTRIBUTOR HIPC SIGNATURES CONTRIBUTOR_ORG NIAID/HIPC SIGNATURES EXACT_SOURCE Suppl File 1, Table 3 FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3713456/bin/elife-00299-supp1.xlsx SOURCE_MEMBERS AKAP7,BANF2,BDKRB1,C22orf30,CHX10,DNASE1L1,DUSP5,EPPK1,FARP2,GPBAR1,IRX1,ITPRIPL2,KCMF1,KDM2B,MUC6,NAPA,NEXN,NPC2,PGLYRP4,PTPN6,RBMX2,RTF1,RXRG,SERPINA13,SPATA13,STAC2,TIPRL,ZNF146 GENE_SYMBOLS AKAP7,BANF2,BDKRB1,PRR14L,VSX2,DNASE1L1,DUSP5,EPPK1,FARP2,GPBAR1,IRX1,ITPRIPL2,KCMF1,KDM2B,MUC6,NAPA,NEXN,NPC2,PGLYRP4,PTPN6,RBMX2,RTF1,RXRG,SERPINA13P,SPATA13,STAC2,TIPRL,ZNF146 FOUNDER_NAMES