STANDARD_NAME	FRANCO_BLOOD_SANOFI_PASTEUR_SA_INACTIVATED_INFLUENZA_VACCINE_CORRELATED_WITH_ANTIBODY_RESPONSE_AGE_18_40YO_3DY_POSITIVE
SYSTEMATIC_NAME	M41040
COLLECTION	C7:VAX
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/FRANCO_BLOOD_SANOFI_PASTEUR_SA_INACTIVATED_INFLUENZA_VACCINE_CORRELATED_WITH_ANTIBODY_RESPONSE_AGE_18_40YO_3DY_POSITIVE
NAMESPACE	HUMAN_GENE_SYMBOL
DESCRIPTION_BRIEF	Genes positively correlated with antibody response in blood in adults (18-40) after exposure to Sanofi Pasteur, SA, Inactivated influenza vaccine , time point 3D
DESCRIPTION_FULL	Identification of the host genetic factors that contribute to variation in vaccine responsiveness may uncover important mechanisms affecting vaccine efficacy. We carried out an integrative, longitudinal study combining genetic, transcriptional, and immunologic data in humans given seasonal influenza vaccine. We identified 20 genes exhibiting a transcriptional response to vaccination, significant genotype effects on gene expression, and correlation between the transcriptional and antibody responses. The results show that variation at the level of genes involved in membrane trafficking and antigen processing significantly influences the human response to influenza vaccination. More broadly, we demonstrate that an integrative study design is an efficient alternative to existing methods for the identification of genes involved in complex traits. DOI:http://dx.doi.org/10.7554/eLife.00299.001.
PMID	23878721
GEOID	
AUTHORS	Franco LM,Bucasas KL,Wells JM,Niño D,Wang X,Zapata GE,Arden N,Renwick A,Yu P,Quarles JM,Bray MS,Couch RB,Belmont JW,Shaw CA
CONTRIBUTOR	HIPC SIGNATURES
CONTRIBUTOR_ORG	NIAID/HIPC SIGNATURES
EXACT_SOURCE	Suppl File 1, Table 3
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3713456/bin/elife-00299-supp1.xlsx
SOURCE_MEMBERS	ATXN7L2,CDK5RAP2,CEACAM1,CYFIP1,EMILIN2,HIPK2,IL4R,JUP,LUC7L,MERTK,PARC,PATL1,PPP1R16A,PTPRA,RRBP1,RYDEN,SNX29,TBC1D2,TIMM44
GENE_SYMBOLS	ATXN7L2,CDK5RAP2,CEACAM1,CYFIP1,EMILIN2,HIPK2,IL4R,JUP,LUC7L,MERTK,CCL18,PATL1,PPP1R16A,PTPRA,RRBP1,,SNX29,TBC1D2,TIMM44
FOUNDER_NAMES