STANDARD_NAME	FUJII_YBX1_TARGETS_DN
SYSTEMATIC_NAME	M14340
COLLECTION	C2:CGP
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/FUJII_YBX1_TARGETS_DN
NAMESPACE	HUMAN_SEQ_ACCESSION
DESCRIPTION_BRIEF	Genes down-regulated in MCF-7 cells (breast cancer) after knockdown of YBX1 [GeneID=4904] by RNAi.
DESCRIPTION_FULL	In our present study, we examined whether nuclear localization of Y-box binding protein-1 (YB-1) is associated with the expression of epidermal growth factor receptors (EGFR), hormone receptors, and other molecules affecting breast cancer prognosis. The expression of nuclear YB-1, clinicopathologic findings, and molecular markers [EGFR, HER2, estrogen receptor (ER)alpha, ER beta, progesterone receptor, chemokine (C-X-C motif) receptor 4 (CXCR4), phosphorylated Akt, and major vault protein/lung resistance protein] were immunohistochemically analyzed. The association of the expression of nuclear YB-1 and the molecular markers was examined in breast cancer cell lines using microarrays, quantitative real-time PCR, and Western blot analyses. Knockdown of YB-1 with siRNA significantly reduced EGFR, HER2, and ER alpha expression in ER alpha-positive, but not ER alpha-negative, breast cancer cell lines. Nuclear YB-1 expression was positively correlated with HER2 (P = 0.0153) and negatively correlated with ER alpha (P = 0.0122) and CXCR4 (P = 0.0166) in human breast cancer clinical specimens but was not correlated with EGFR expression. Nuclear YB-1 expression was an independent prognostic factor for overall (P = 0.0139) and progression-free (P = 0.0280) survival. In conclusion, nuclear YB-1 expression might be essential for the acquisition of malignant characteristics via HER2-Akt-dependent pathways in breast cancer patients. The nuclear localization of YB-1 could be an important therapeutic target against not only multidrug resistance but also tumor growth dependent on HER2 and ER alpha.
PMID	18316615
GEOID	
AUTHORS	Fujii T,Kawahara A,Basaki Y,Hattori S,Nakashima K,Nakano K,Shirouzu K,Kohno K,Yanagawa T,Yamana H,Nishio K,Ono M,Kuwano M,Kage M
CONTRIBUTOR	Jessica Robertson
CONTRIBUTOR_ORG	MSigDB Team
EXACT_SOURCE	Table 1S
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	AA176247,AA463221,AA534860,AA579890,AA706316,AA807529,AA888858,AA902971,AA912743,AB006572,AB012305,AB040927,AB049113,AF001903,AF010316,AF044221,AF053970,AF080255,AF080398,AF086924,AF095192,AF142573,AF155827,AF167343,AF213033,AF220509,AF225416,AF275260,AF277178,AF277724,AF321125,AF360549,AI073943,AI202201,AI224977,AI302106,AI340270,AI341146,AI492873,AI625550,AI654093,AI692974,AI718385,AI798207,AI806853,AI810054,AI816243,AI936566,AI963713,AI990326,AJ224869,AK001166,AK001261,AK022829,AK025578,AL043646,AL110225,AL136616,AL136840,AL534416,AL565621,AU148466,AU159942,AV697515,AV720650,AW006441,AW024870,AW192521,AW242820,AW291083,AW296067,AW575374,AW592266,AW771919,AW968555,AW975728,AY029179,AY137580,BC000192,BC000323,BC001075,BC001255,BC001441,BC001650,BC001866,BC001886,BC002493,BC003186,BC004248,BC004815,BC005400,BC006471,BC007986,BC032240,BE000929,BE045993,BE378479,BE544837,BE795648,BF000239,BF108964,BF197357,BF438417,BF512200,BF700678,BQ021146,D38553,D55716,D81048,J03225,M30894,N21108,N62196,NM_000082,NM_000234,NM_000362,NM_000436,NM_000946,NM_001211,NM_001274,NM_001392,NM_001444,NM_001533,NM_001724,NM_001826,NM_002084,NM_002105,NM_002208,NM_002222,NM_002358,NM_002388,NM_002466,NM_002539,NM_002689,NM_002692,NM_002736,NM_002874,NM_002875,NM_002915,NM_002916,NM_003144,NM_003362,NM_003384,NM_003405,NM_003686,NM_003920,NM_004085,NM_004237,NM_004401,NM_004523,NM_004526,NM_004661,NM_004879,NM_005573,NM_005915,NM_005931,NM_006048,NM_006260,NM_006392,NM_006397,NM_006466,NM_006807,NM_007057,NM_007295,NM_012099,NM_012145,NM_012177,NM_012242,NM_012310,NM_012346,NM_012415,NM_014109,NM_014171,NM_014791,NM_016172,NM_016359,NM_017425,NM_017760,NM_017858,NM_018136,NM_018154,NM_018248,NM_018283,NM_018455,NM_020128,NM_020648,NM_021953,NM_022116,NM_024629,NM_024745,NM_025263,NM_030780,NM_152696,NM_152903,U13022,U17105,U34994,U67280,U77949,U88989,U90902,W74442,X06268
GENE_SYMBOLS	PRPF40A,ANKRD36,H2AZ2,FANCD2,DMKN,MCM5,PDE3B,CLCN3,PTK2,,CDK2,SH3RF1,DUT,HADH,PTGES,UBL3,ODF2,TTF2,MAD2L2,PPP2R2C,BAG2,CRISPLD1,HELLS,IL1RAP,CDKN3,TAF9B,SPC25,CXCL16,SSU72,CDC25C,CDT1,BRIP1,NEK8,JPH1,PARPBP,RAP2A,,E2F7,PPP1R10,FLNA,FUT8,RRM1,SLC26A2,PHKB,HMGB3,DEPDC1,,MCM4,ENAH,,CXCR4,DEPDC1B,DTL,XRCC3,UHRF1,PLK4,DBN1,PLPBP,MCM10,ZBTB14,COTL1,IPO5,TOP2A,RDH10,,MGAT4A,NSD2,KIF23,,VAPB,TAF15,,MYBL1,,TBL1X,SLC16A7,CDCA7,CDC25A,DHFR,FEN1,SLC25A19,NCBP2,SKP2,METTL3,RFC5,RRM2,TCF19,GINS2,BMP7,UNC119B,CENPK,MLLT11,TK1,RECK,MSI2,OIP5,HDLBP,PHF19,SSRP1,CHAF1A,MASTL,CCT5,IREB2,MBNL1,CDK8,,NCAPH,MCM7,NRM,TFPI,TARP,TRIO,ZNF367,ERCC8,LIG1,TIMP3,OXCT1,PRIM1,BUB1B,CHEK1,DTNA,FABP5,HNRNPL,BPGM,CKS1B,GPX3,H2AX,ITGAE,ITPR1,MAD2L1,MCM3,MYBL2,ODC1,POLA2,POLE2,PRKAR2B,RAD23B,RAD51,RFC3,RFC4,SSR1,UNG,VRK1,YWHAH,EXO1,TIMELESS,TIMM8A,TRIP13,DFFA,KIF11,MCM2,CDC23,EI24,LMNB1,MCM6,MICB,UBE4B,DNAJC3,NOP56,RNASEH2A,POLR3F,CBX1,ZWINT,BRCA1,POLR1G,DTYMK,FBXO5,DKK1,KIF4A,NUP62,RAD54B,ATAD2,CRIPT,MELK,UBAC1,NUSAP1,SPA17,NCAPG2,TIPIN,ASPM,ASF1B,NEIL3,NUDT15,CENPN,MDM1,TWSG1,FOXM1,FIGNL1,CENPU,SHCBP1,PRR3,SLC25A32,HIPK1,KBTBD6,CASP2,CCNF,PRKDC,CALU,CDC6,EIF4EBP2,TIAM1,FANCI,COL2A1
FOUNDER_NAMES