<?xml version="1.0" encoding="UTF-8" standalone="yes"?>

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     See license terms at www.gsea-msigdb.org/gsea/license_terms_list. Please note that certain gene sets have special access terms.
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<MSIGDB BUILD_DATE="Jan 29, 2026" VERSION="2026.1.Hs" NAME="export">
    <GENESET STANDARD_NAME="FUJII_YBX1_TARGETS_DN" SYSTEMATIC_NAME="M14340" HISTORICAL_NAMES="" PMID="18316615" AUTHORS="Fujii T,Kawahara A,Basaki Y,Hattori S,Nakashima K,Nakano K,Shirouzu K,Kohno K,Yanagawa T,Yamana H,Nishio K,Ono M,Kuwano M,Kage M" GEOID="" EXACT_SOURCE="Table 1S" GENESET_LISTING_URL="" EXTERNAL_DETAILS_URL="" CHIP="HUMAN_SEQ_ACCESSION" CONTRIBUTOR="Jessica Robertson" CONTRIBUTOR_ORG="MSigDB Team" DESCRIPTION_BRIEF="Genes down-regulated in MCF-7 cells (breast cancer) after knockdown of YBX1 [GeneID=4904] by RNAi." DESCRIPTION_FULL="In our present study, we examined whether nuclear localization of Y-box binding protein-1 (YB-1) is associated with the expression of epidermal growth factor receptors (EGFR), hormone receptors, and other molecules affecting breast cancer prognosis. The expression of nuclear YB-1, clinicopathologic findings, and molecular markers [EGFR, HER2, estrogen receptor (ER)alpha, ER beta, progesterone receptor, chemokine (C-X-C motif) receptor 4 (CXCR4), phosphorylated Akt, and major vault protein/lung resistance protein] were immunohistochemically analyzed. The association of the expression of nuclear YB-1 and the molecular markers was examined in breast cancer cell lines using microarrays, quantitative real-time PCR, and Western blot analyses. Knockdown of YB-1 with siRNA significantly reduced EGFR, HER2, and ER alpha expression in ER alpha-positive, but not ER alpha-negative, breast cancer cell lines. Nuclear YB-1 expression was positively correlated with HER2 (P = 0.0153) and negatively correlated with ER alpha (P = 0.0122) and CXCR4 (P = 0.0166) in human breast cancer clinical specimens but was not correlated with EGFR expression. Nuclear YB-1 expression was an independent prognostic factor for overall (P = 0.0139) and progression-free (P = 0.0280) survival. In conclusion, nuclear YB-1 expression might be essential for the acquisition of malignant characteristics via HER2-Akt-dependent pathways in breast cancer patients. The nuclear localization of YB-1 could be an important therapeutic target against not only multidrug resistance but also tumor growth dependent on HER2 and ER alpha." TAGS="" MEMBERS="AA176247,AA463221,AA534860,AA579890,AA706316,AA807529,AA888858,AA902971,AA912743,AB006572,AB012305,AB040927,AB049113,AF001903,AF010316,AF044221,AF053970,AF080255,AF080398,AF086924,AF095192,AF142573,AF155827,AF167343,AF213033,AF220509,AF225416,AF275260,AF277178,AF277724,AF321125,AF360549,AI073943,AI202201,AI224977,AI302106,AI340270,AI341146,AI492873,AI625550,AI654093,AI692974,AI718385,AI798207,AI806853,AI810054,AI816243,AI936566,AI963713,AI990326,AJ224869,AK001166,AK001261,AK022829,AK025578,AL043646,AL110225,AL136616,AL136840,AL534416,AL565621,AU148466,AU159942,AV697515,AV720650,AW006441,AW024870,AW192521,AW242820,AW291083,AW296067,AW575374,AW592266,AW771919,AW968555,AW975728,AY029179,AY137580,BC000192,BC000323,BC001075,BC001255,BC001441,BC001650,BC001866,BC001886,BC002493,BC003186,BC004248,BC004815,BC005400,BC006471,BC007986,BC032240,BE000929,BE045993,BE378479,BE544837,BE795648,BF000239,BF108964,BF197357,BF438417,BF512200,BF700678,BQ021146,D38553,D55716,D81048,J03225,M30894,N21108,N62196,NM_000082,NM_000234,NM_000362,NM_000436,NM_000946,NM_001211,NM_001274,NM_001392,NM_001444,NM_001533,NM_001724,NM_001826,NM_002084,NM_002105,NM_002208,NM_002222,NM_002358,NM_002388,NM_002466,NM_002539,NM_002689,NM_002692,NM_002736,NM_002874,NM_002875,NM_002915,NM_002916,NM_003144,NM_003362,NM_003384,NM_003405,NM_003686,NM_003920,NM_004085,NM_004237,NM_004401,NM_004523,NM_004526,NM_004661,NM_004879,NM_005573,NM_005915,NM_005931,NM_006048,NM_006260,NM_006392,NM_006397,NM_006466,NM_006807,NM_007057,NM_007295,NM_012099,NM_012145,NM_012177,NM_012242,NM_012310,NM_012346,NM_012415,NM_014109,NM_014171,NM_014791,NM_016172,NM_016359,NM_017425,NM_017760,NM_017858,NM_018136,NM_018154,NM_018248,NM_018283,NM_018455,NM_020128,NM_020648,NM_021953,NM_022116,NM_024629,NM_024745,NM_025263,NM_030780,NM_152696,NM_152903,U13022,U17105,U34994,U67280,U77949,U88989,U90902,W74442,X06268" MEMBERS_SYMBOLIZED="ANKRD36,ASF1B,ASPM,ATAD2,BAG2,BMP7,BPGM,BRCA1,BRIP1,BUB1B,CALU,CASP2,CBX1,CCNF,CCT5,CDC23,CDC25A,CDC25C,CDC6,CDCA7,CDK2,CDK8,CDKN3,CDT1,CENPK,CENPN,CENPU,CHAF1A,CHEK1,CKS1B,CLCN3,COL2A1,COTL1,CRIPT,CRISPLD1,CXCL16,CXCR4,DBN1,DEPDC1,DEPDC1B,DFFA,DHFR,DKK1,DMKN,DNAJC3,DTL,DTNA,DTYMK,DUT,E2F7,EI24,EIF4EBP2,ENAH,ERCC8,EXO1,FABP5,FANCD2,FANCI,FBXO5,FEN1,FIGNL1,FLNA,FOXM1,FUT8,GINS2,GPX3,H2AX,H2AZ2,HADH,HDLBP,HELLS,HIPK1,HMGB3,HNRNPL,IL1RAP,IPO5,IREB2,ITGAE,ITPR1,JPH1,KBTBD6,KIF11,KIF23,KIF4A,LIG1,LMNB1,MAD2L1,MAD2L2,MASTL,MBNL1,MCM10,MCM2,MCM3,MCM4,MCM5,MCM6,MCM7,MDM1,MELK,METTL3,MGAT4A,MICB,MLLT11,MSI2,MYBL1,MYBL2,NCAPG2,NCAPH,NCBP2,NEIL3,NEK8,NOP56,NRM,NSD2,NUDT15,NUP62,NUSAP1,ODC1,ODF2,OIP5,OXCT1,PARPBP,PDE3B,PHF19,PHKB,PLK4,PLPBP,POLA2,POLE2,POLR1G,POLR3F,PPP1R10,PPP2R2C,PRIM1,PRKAR2B,PRKDC,PRPF40A,PRR3,PTGES,PTK2,RAD23B,RAD51,RAD54B,RAP2A,RDH10,RECK,RFC3,RFC4,RFC5,RNASEH2A,RRM1,RRM2,SH3RF1,SHCBP1,SKP2,SLC16A7,SLC25A19,SLC25A32,SLC26A2,SPA17,SPC25,SSR1,SSRP1,SSU72,TAF15,TAF9B,TARP,TBL1X,TCF19,TFPI,TIAM1,TIMELESS,TIMM8A,TIMP3,TIPIN,TK1,TOP2A,TRIO,TRIP13,TTF2,TWSG1,UBAC1,UBE4B,UBL3,UHRF1,UNC119B,UNG,VAPB,VRK1,XRCC3,YWHAH,ZBTB14,ZNF367,ZWINT" MEMBERS_EZID="10036,1017,1024,10277,1033,10422,10459,10528,10535,10621,10733,10849,10951,10962,1111,11130,11212,11270,11320,11339,1161,1163,1182,124540,1280,144455,157506,1627,1676,1678,1719,1836,1837,1841,1854,195828,1979,204851,2171,2177,2237,22916,22943,22948,2305,2316,23397,23406,23636,23649,24137,2530,25788,259266,26147,26271,284086,2878,29028,29101,29128,3014,3033,3069,3070,3149,3191,3556,3658,3682,3708,375248,3832,3843,3978,4001,4085,4154,4171,4172,4173,4174,4175,4176,4277,445347,4603,4605,4953,4957,5019,51203,5140,51514,51616,51659,5257,53340,5412,5427,54892,54962,55010,5514,55215,5522,55247,55270,55388,5557,55635,55660,55723,55740,5577,55789,55839,5591,5611,56339,56704,56890,57045,57405,5747,57630,58191,5887,5888,5911,5983,5984,5985,60386,6240,6241,63979,64105,6502,655,669,672,6745,6749,6907,6941,701,7035,7074,7078,7083,7153,7204,7374,7443,7468,7517,7533,7541,7852,79682,79801,80742,81034,813,8148,81620,835,83690,83879,83990,8434,8458,84747,84930,8697,8914,89890,899,9156,9194,9217,93099,9319,9419,94239,9493,9532,9536,9538,9833,990,993,995" MEMBERS_MAPPING="AA176247,PRPF40A,55660|AA463221,ANKRD36,375248|AA534860,H2AZ2,94239|AA579890,FANCD2,2177|AA706316,DMKN,93099|AA807529,MCM5,4174|AA888858,PDE3B,5140|AA902971,CLCN3,1182|AA912743,PTK2,5747|AB006572,null,null|AB012305,CDK2,1017|AB040927,SH3RF1,57630|AB049113,DUT,1854|AF001903,HADH,3033|AF010316,PTGES,9536|AF044221,UBL3,5412|AF053970,ODF2,4957|AF080255,TTF2,8458|AF080398,MAD2L2,10459|AF086924,PPP2R2C,5522|AF095192,BAG2,9532|AF142573,CRISPLD1,83690|AF155827,HELLS,3070|AF167343,IL1RAP,3556|AF213033,CDKN3,1033|AF220509,TAF9B,51616|AF225416,SPC25,57405|AF275260,CXCL16,58191|AF277178,SSU72,29101|AF277724,CDC25C,995|AF321125,CDT1,81620|AF360549,BRIP1,83990|AI073943,NEK8,284086|AI202201,JPH1,56704|AI224977,PARPBP,55010|AI302106,RAP2A,5911|AI340270,null,null|AI341146,E2F7,144455|AI492873,PPP1R10,5514|AI625550,FLNA,2316|AI654093,FUT8,2530|AI692974,RRM1,6240|AI718385,SLC26A2,1836|AI798207,PHKB,5257|AI806853,HMGB3,3149|AI810054,DEPDC1,55635|AI816243,null,null|AI936566,MCM4,4173|AI963713,ENAH,55740|AI990326,null,null|AJ224869,CXCR4,7852|AK001166,DEPDC1B,55789|AK001261,DTL,51514|AK022829,XRCC3,7517|AK025578,UHRF1,29128|AL043646,PLK4,10733|AL110225,DBN1,1627|AL136616,PLPBP,11212|AL136840,MCM10,55388|AL534416,ZBTB14,7541|AL565621,COTL1,23406|AU148466,IPO5,3843|AU159942,TOP2A,7153|AV697515,RDH10,157506|AV720650,null,null|AW006441,MGAT4A,11320|AW024870,NSD2,7468|AW192521,KIF23,9493|AW242820,null,null|AW291083,VAPB,9217|AW296067,TAF15,8148|AW575374,null,null|AW592266,MYBL1,4603|AW771919,null,null|AW968555,TBL1X,6907|AW975728,SLC16A7,9194|AY029179,CDCA7,83879|AY137580,CDC25A,993|BC000192,DHFR,1719|BC000323,FEN1,2237|BC001075,SLC25A19,60386|BC001255,NCBP2,22916|BC001441,SKP2,6502|BC001650,METTL3,56339|BC001866,RFC5,5985|BC001886,RRM2,6241|BC002493,TCF19,6941|BC003186,GINS2,51659|BC004248,BMP7,655|BC004815,UNC119B,84747|BC005400,CENPK,64105|BC006471,MLLT11,10962|BC007986,TK1,7083|BC032240,RECK,8434|BE000929,MSI2,124540|BE045993,OIP5,11339|BE378479,HDLBP,3069|BE544837,PHF19,26147|BE795648,SSRP1,6749|BF000239,CHAF1A,10036|BF108964,MASTL,84930|BF197357,CCT5,22948|BF438417,IREB2,3658|BF512200,MBNL1,4154|BF700678,CDK8,1024|BQ021146,null,null|D38553,NCAPH,23397|D55716,MCM7,4176|D81048,NRM,11270|J03225,TFPI,7035|M30894,TARP,445347|N21108,TRIO,7204|N62196,ZNF367,195828|NM_000082,ERCC8,1161|NM_000234,LIG1,3978|NM_000362,TIMP3,7078|NM_000436,OXCT1,5019|NM_000946,PRIM1,5557|NM_001211,BUB1B,701|NM_001274,CHEK1,1111|NM_001392,DTNA,1837|NM_001444,FABP5,2171|NM_001533,HNRNPL,3191|NM_001724,BPGM,669|NM_001826,CKS1B,1163|NM_002084,GPX3,2878|NM_002105,H2AX,3014|NM_002208,ITGAE,3682|NM_002222,ITPR1,3708|NM_002358,MAD2L1,4085|NM_002388,MCM3,4172|NM_002466,MYBL2,4605|NM_002539,ODC1,4953|NM_002689,POLA2,23649|NM_002692,POLE2,5427|NM_002736,PRKAR2B,5577|NM_002874,RAD23B,5887|NM_002875,RAD51,5888|NM_002915,RFC3,5983|NM_002916,RFC4,5984|NM_003144,SSR1,6745|NM_003362,UNG,7374|NM_003384,VRK1,7443|NM_003405,YWHAH,7533|NM_003686,EXO1,9156|NM_003920,TIMELESS,8914|NM_004085,TIMM8A,1678|NM_004237,TRIP13,9319|NM_004401,DFFA,1676|NM_004523,KIF11,3832|NM_004526,MCM2,4171|NM_004661,CDC23,8697|NM_004879,EI24,9538|NM_005573,LMNB1,4001|NM_005915,MCM6,4175|NM_005931,MICB,4277|NM_006048,UBE4B,10277|NM_006260,DNAJC3,5611|NM_006392,NOP56,10528|NM_006397,RNASEH2A,10535|NM_006466,POLR3F,10621|NM_006807,CBX1,10951|NM_007057,ZWINT,11130|NM_007295,BRCA1,672|NM_012099,POLR1G,10849|NM_012145,DTYMK,1841|NM_012177,FBXO5,26271|NM_012242,DKK1,22943|NM_012310,KIF4A,24137|NM_012346,NUP62,23636|NM_012415,RAD54B,25788|NM_014109,ATAD2,29028|NM_014171,CRIPT,9419|NM_014791,MELK,9833|NM_016172,UBAC1,10422|NM_016359,NUSAP1,51203|NM_017425,SPA17,53340|NM_017760,NCAPG2,54892|NM_017858,TIPIN,54962|NM_018136,ASPM,259266|NM_018154,ASF1B,55723|NM_018248,NEIL3,55247|NM_018283,NUDT15,55270|NM_018455,CENPN,55839|NM_020128,MDM1,56890|NM_020648,TWSG1,57045|NM_021953,FOXM1,2305|NM_022116,FIGNL1,63979|NM_024629,CENPU,79682|NM_024745,SHCBP1,79801|NM_025263,PRR3,80742|NM_030780,SLC25A32,81034|NM_152696,HIPK1,204851|NM_152903,KBTBD6,89890|U13022,CASP2,835|U17105,CCNF,899|U34994,PRKDC,5591|U67280,CALU,813|U77949,CDC6,990|U88989,EIF4EBP2,1979|U90902,TIAM1,7074|W74442,FANCI,55215|X06268,COL2A1,1280" FILTERED_BY_SIMILARITY="" FOUNDER_NAMES="" REFINEMENT_DATASETS="" VALIDATION_DATASETS="" CATEGORY_CODE="C2" ORGANISM="Homo sapiens" SUB_CATEGORY_CODE="CGP"/>
</MSIGDB>
