STANDARD_NAME	FUNG_IL2_SIGNALING_2
SYSTEMATIC_NAME	M10198
COLLECTION	C2:CGP
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/FUNG_IL2_SIGNALING_2
NAMESPACE	Human_RefSeq
DESCRIPTION_BRIEF	Genes up-regulated by IL2 [GeneID=3558] in T1 cells (primary thymocytes immortalized by Tax, an HTLV-1 encoded gene).
DESCRIPTION_FULL	Interleukin-2 (IL-2) mediates cell cycle progression and antiapoptosis in human T cells via several signal transduction pathways. The Tax protein of the human T-cell leukemia virus type I (HTLV-1) deregulates cell growth and alters the role of IL-2 in infected cells. However, Tax-immortalized cells stay dependent on IL-2, suggesting that events besides HTLV-1 gene expression are required for leukemia to develop. Here, IL-2-dependent and -independent events were analysed in a human T cell line immortalized by Tax. These studies show that, of the signaling pathways evaluated, only STAT5 remains dependent. Microarray analyses revealed several genes, including il-5, il-9 and il-13, are uniquely upregulated by IL-2 in the presence of Tax. Bioinformatics and supporting molecular biology show that some of these genes are STAT5 targets, explaining their IL-2 upregulation. These results suggest that IL-2 and viral proteins work together to induce gene expression, promoting the hypothesis that deregulation via the constitutive activation of STAT5 may lead to the IL-2-independent phenotype of HTLV-1-transformed cells.
PMID	15735688
GEOID	
AUTHORS	Fung MM,Chu YL,Fink JL,Wallace A,McGuire KL
CONTRIBUTOR	Arthur Liberzon
CONTRIBUTOR_ORG	MSigDB Team
EXACT_SOURCE	Table 1: Genes uniquely upregulated by IL-2 in T1
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	NM_000590,NM_000879,NM_002188,NM_002460,NM_002467,NM_002546,NM_002983,NM_004367,NM_004728,NM_021194,NM_022352,NM_024508
GENE_SYMBOLS	IL9,IL5,IL13,IRF4,MYC,TNFRSF11B,CCL3,CCR6,DDX21,SLC30A1,CARD9,ZBED2
FOUNDER_NAMES