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<MSIGDB BUILD_DATE="Jan 29, 2026" VERSION="2026.1.Hs" NAME="export">
    <GENESET STANDARD_NAME="FUNG_IL2_SIGNALING_2" SYSTEMATIC_NAME="M10198" HISTORICAL_NAMES="" PMID="15735688" AUTHORS="Fung MM,Chu YL,Fink JL,Wallace A,McGuire KL" GEOID="" EXACT_SOURCE="Table 1: Genes uniquely upregulated by IL-2 in T1" GENESET_LISTING_URL="" EXTERNAL_DETAILS_URL="" CHIP="Human_RefSeq" CONTRIBUTOR="Arthur Liberzon" CONTRIBUTOR_ORG="MSigDB Team" DESCRIPTION_BRIEF="Genes up-regulated by IL2 [GeneID=3558] in T1 cells (primary thymocytes immortalized by Tax, an HTLV-1 encoded gene)." DESCRIPTION_FULL="Interleukin-2 (IL-2) mediates cell cycle progression and antiapoptosis in human T cells via several signal transduction pathways. The Tax protein of the human T-cell leukemia virus type I (HTLV-1) deregulates cell growth and alters the role of IL-2 in infected cells. However, Tax-immortalized cells stay dependent on IL-2, suggesting that events besides HTLV-1 gene expression are required for leukemia to develop. Here, IL-2-dependent and -independent events were analysed in a human T cell line immortalized by Tax. These studies show that, of the signaling pathways evaluated, only STAT5 remains dependent. Microarray analyses revealed several genes, including il-5, il-9 and il-13, are uniquely upregulated by IL-2 in the presence of Tax. Bioinformatics and supporting molecular biology show that some of these genes are STAT5 targets, explaining their IL-2 upregulation. These results suggest that IL-2 and viral proteins work together to induce gene expression, promoting the hypothesis that deregulation via the constitutive activation of STAT5 may lead to the IL-2-independent phenotype of HTLV-1-transformed cells." TAGS="" MEMBERS="NM_000590,NM_000879,NM_002188,NM_002460,NM_002467,NM_002546,NM_002983,NM_004367,NM_004728,NM_021194,NM_022352,NM_024508" MEMBERS_SYMBOLIZED="CARD9,CCL3,CCR6,DDX21,IL13,IL5,IL9,IRF4,MYC,SLC30A1,TNFRSF11B,ZBED2" MEMBERS_EZID="1235,3567,3578,3596,3662,4609,4982,6348,64170,7779,79413,9188" MEMBERS_MAPPING="NM_000590,IL9,3578|NM_000879,IL5,3567|NM_002188,IL13,3596|NM_002460,IRF4,3662|NM_002467,MYC,4609|NM_002546,TNFRSF11B,4982|NM_002983,CCL3,6348|NM_004367,CCR6,1235|NM_004728,DDX21,9188|NM_021194,SLC30A1,7779|NM_022352,CARD9,64170|NM_024508,ZBED2,79413" FILTERED_BY_SIMILARITY="" FOUNDER_NAMES="" REFINEMENT_DATASETS="" VALIDATION_DATASETS="" CATEGORY_CODE="C2" ORGANISM="Homo sapiens" SUB_CATEGORY_CODE="CGP"/>
</MSIGDB>
