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<MSIGDB BUILD_DATE="Jan 29, 2026" VERSION="2026.1.Hs" NAME="export">
    <GENESET STANDARD_NAME="FUNG_IL2_TARGETS_WITH_STAT5_BINDING_SITES" SYSTEMATIC_NAME="M19436" HISTORICAL_NAMES="" PMID="15735688" AUTHORS="Fung MM,Chu YL,Fink JL,Wallace A,McGuire KL" GEOID="" EXACT_SOURCE="Table 3: Genes upregulated by IL-2 in T1 and primary T cells" GENESET_LISTING_URL="" EXTERNAL_DETAILS_URL="" CHIP="Human_RefSeq" CONTRIBUTOR="Arthur Liberzon" CONTRIBUTOR_ORG="MSigDB Team" DESCRIPTION_BRIEF="Genes with putative STAT5 [GeneID=6777] binding sites; up-regulated by IL2 [Gene D=3558] in both primary thymocytes and T1 cells (primary thymocytes immortalized by Tax, an HTLV-1 encoded gene)." DESCRIPTION_FULL="Interleukin-2 (IL-2) mediates cell cycle progression and antiapoptosis in human T cells via several signal transduction pathways. The Tax protein of the human T-cell leukemia virus type I (HTLV-1) deregulates cell growth and alters the role of IL-2 in infected cells. However, Tax-immortalized cells stay dependent on IL-2, suggesting that events besides HTLV-1 gene expression are required for leukemia to develop. Here, IL-2-dependent and -independent events were analysed in a human T cell line immortalized by Tax. These studies show that, of the signaling pathways evaluated, only STAT5 remains dependent. Microarray analyses revealed several genes, including il-5, il-9 and il-13, are uniquely upregulated by IL-2 in the presence of Tax. Bioinformatics and supporting molecular biology show that some of these genes are STAT5 targets, explaining their IL-2 upregulation. These results suggest that IL-2 and viral proteins work together to induce gene expression, promoting the hypothesis that deregulation via the constitutive activation of STAT5 may lead to the IL-2-independent phenotype of HTLV-1-transformed cells." TAGS="" MEMBERS="NM_000417,NM_000595,NM_001363,NM_001759,NM_002309,NM_003877,NM_016391" MEMBERS_SYMBOLIZED="CCND2,DKC1,IL2RA,LIF,LTA,NOP16,SOCS2" MEMBERS_EZID="1736,3559,3976,4049,51491,8835,894" MEMBERS_MAPPING="NM_000417,IL2RA,3559|NM_000595,LTA,4049|NM_001363,DKC1,1736|NM_001759,CCND2,894|NM_002309,LIF,3976|NM_003877,SOCS2,8835|NM_016391,NOP16,51491" FILTERED_BY_SIMILARITY="" FOUNDER_NAMES="" REFINEMENT_DATASETS="" VALIDATION_DATASETS="" CATEGORY_CODE="C2" ORGANISM="Homo sapiens" SUB_CATEGORY_CODE="CGP"/>
</MSIGDB>
