STANDARD_NAME	GALIE_TUMOR_ANGIOGENESIS
SYSTEMATIC_NAME	M1294
COLLECTION	C2:CGP
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GALIE_TUMOR_ANGIOGENESIS
NAMESPACE	Mouse_RefSeq
DESCRIPTION_BRIEF	Angiogenic genes up-regulated in A17 carcinomas (high vascularization) compared to the syngeneic BB1 and spontaneous tumors (little vascularization).
DESCRIPTION_FULL	Tumor microenvironment in carcinomas recruits mesenchymal cells with an abnormal proangiogenic and invasive phenotype. It is not clear whether mesenchymal tumor cells (MTCs) derive from the activation of mature fibroblasts or from their stem cell precursors. However, stromal cell activation in tumors resembles in several aspects the mesenchymal rearrangement which normally occurs during reparative processes such as wound healing. Mesenchymal stem cells (MSCs) play a crucial role in developmental and reparative processes and have extraordinary proangiogenic potential, on the basis of which they are thought to show great promise for the treatment of ischemic disorders. Here, we show that MTCs have proangiogenic potential and that they share the transcriptional expression of the best-known proangiogenic factors with MSCs. We also found that MTCs and MSCs have the same molecular signature for stemness-related genes, and that when co-implanted with cancer cells in syngeneic animals MSCs determine early tumor appearance, probably by favoring the angiogenic switch. Our data (1) reveal crucial aspects of the proangiogenic phenotype of MTCs, (2) strongly suggest their stem origin and (3) signal the risk of therapeutic use of MSCs in tumor-promoting conditions.
PMID	17998939
GEOID	
AUTHORS	Galiè M,Konstantinidou G,Peroni D,Scambi I,Marchini C,Lisi V,Krampera M,Magnani P,Merigo F,Montani M,Boschi F,Marzola P,Orrù R,Farace P,Sbarbati A,Amici A
CONTRIBUTOR	Jessica Robertson
CONTRIBUTOR_ORG	MSigDB Team
EXACT_SOURCE	Table 2
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	NM_007426,NM_008808,NM_009640,NM_010217,NM_010427,NM_010512,NM_011198,NM_011577
GENE_SYMBOLS	ANGPT2,PDGFA,ANGPT1,CCN2,HGF,IGF1,PTGS2,TGFB1
FOUNDER_NAMES