STANDARD_NAME	GAUCHER_PBMC_YF_VAX_STAMARIL_UNKNOWN_AGE_14DY_UP
SYSTEMATIC_NAME	M40954
COLLECTION	C7:VAX
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GAUCHER_PBMC_YF_VAX_STAMARIL_UNKNOWN_AGE_14DY_UP
NAMESPACE	HUMAN_GENE_SYMBOL
DESCRIPTION_BRIEF	Genes up-regulated in peripheral blood mononuclear cell 14d vs 0d in unknown after exposure to YF-Vax/Stamaril , time point 14D
DESCRIPTION_FULL	Correlates of immune-mediated protection to most viral and cancer vaccines are still unknown. This impedes the development of novel vaccines to incurable diseases such as HIV and cancer. In this study, we have used functional genomics and polychromatic flow cytometry to define the signature of the immune response to the yellow fever (YF) vaccine 17D (YF17D) in a cohort of 40 volunteers followed for up to 1 yr after vaccination. We show that immunization with YF17D leads to an integrated immune response that includes several effector arms of innate immunity, including complement, the inflammasome, and interferons, as well as adaptive immunity as shown by an early T cell response followed by a brisk and variable B cell response. Development of these responses is preceded, as demonstrated in three independent vaccination trials and in a novel in vitro system of primary immune responses (modular immune in vitro construct [MIMIC] system), by the coordinated up-regulation of transcripts for specific transcription factors, including STAT1, IRF7, and ETS2, which are upstream of the different effector arms of the immune response. These results clearly show that the immune response to a strong vaccine is preceded by coordinated induction of master transcription factors that lead to the development of a broad, polyfunctional, and persistent immune response that integrates all effector cells of the immune system.
PMID	19047440
GEOID	
AUTHORS	Gaucher D,Therrien R,Kettaf N,Angermann BR,Boucher G,Filali-Mouhim A,Moser JM,Mehta RS,Drake DR 3rd,Castro E,Akondy R,Rinfret A,Yassine-Diab B,Said EA,Chouikh Y,Cameron MJ,Clum R,Kelvin D,Somogyi R,Greller LD,Balderas RS,Wilkinson P,Pantaleo G,Tartaglia J,Haddad EK,Sékaly RP
CONTRIBUTOR	HIPC SIGNATURES
CONTRIBUTOR_ORG	NIAID/HIPC SIGNATURES
EXACT_SOURCE	Supplemental Document 1
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2605227/bin/jem.20082292_1.pdf
SOURCE_MEMBERS	ACOT7,ADA,ARMET,CCNB2,CD19,CD38,CDC20,CDCA5,CDCA7,CDK12,CENPM,COBLL1,CRELD2,CXCR3,DUSP5,FAM30A,FCRL5,FKBP11,GLDC,HSP90B1,IDH2,ITM2C,JCHAIN,MAGED1,MCM4,MYDGF,MYL6B,MYO1F,MZB1,NME1,NUSAP1,PDIA4,PHGDH,POU2AF1,PPIB,PRDX4,PTTG1,RTCB,SDF2L1,SEC11C,SEL1L3,SIL1,SLC7A5,SP140,SRM,STMN1,TENT5C,TK1,TNFRSF13B,TNFRSF17,TRIM26,TUBG1,TXNDC11,TXNDC5,UBE2C,UBE2S,UHRF1,XBP1
GENE_SYMBOLS	ACOT7,ADA,MANF,CCNB2,CD19,CD38,CDC20,CDCA5,CDCA7,CDK12,CENPM,COBLL1,CRELD2,CXCR3,DUSP5,FAM30A,FCRL5,FKBP11,GLDC,HSP90B1,IDH2,ITM2C,JCHAIN,MAGED1,MCM4,MYDGF,MYL6B,MYO1F,MZB1,NME1,NUSAP1,PDIA4,PHGDH,POU2AF1,PPIB,PRDX4,PTTG1,RTCB,SDF2L1,SEC11C,SEL1L3,SIL1,SLC7A5,SP140,SRM,STMN1,TENT5C,TK1,TNFRSF13B,TNFRSF17,TRIM26,TUBG1,TXNDC11,TXNDC5,UBE2C,UBE2S,UHRF1,XBP1
FOUNDER_NAMES