STANDARD_NAME	GAVIN_IL2_RESPONSIVE_FOXP3_TARGETS_DN
SYSTEMATIC_NAME	M1740
COLLECTION	C2:CGP
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GAVIN_IL2_RESPONSIVE_FOXP3_TARGETS_DN
NAMESPACE	MOUSE_GENE_SYMBOL
DESCRIPTION_BRIEF	FOXP3 [GeneID=50943] target genes down-regulated in T lymphocytes after stimulation with IL2 [GeneID=3558].
DESCRIPTION_FULL	Regulatory CD4+ T cells (Tr cells), the development of which is critically dependent on X-linked transcription factor Foxp3 (forkhead box P3), prevent self-destructive immune responses. Despite its important role, molecular and functional features conferred by Foxp3 to Tr precursor cells remain unknown. It has been suggested that Foxp3 expression is required for both survival of Tr precursors as well as their inability to produce interleukin (IL)-2 and independently proliferate after T-cell-receptor engagement, raising the possibility that such 'anergy' and Tr suppressive capacity are intimately linked. Here we show, by dissociating Foxp3-dependent features from those induced by the signals preceding and promoting its expression in mice, that the latter signals include several functional and transcriptional hallmarks of Tr cells. Although its function is required for Tr cell suppressor activity, Foxp3 to a large extent amplifies and fixes pre-established molecular features of Tr cells, including anergy and dependence on paracrine IL-2. Furthermore, Foxp3 solidifies Tr cell lineage stability through modification of cell surface and signalling molecules, resulting in adaptation to the signals required to induce and maintain Tr cells. This adaptation includes Foxp3-dependent repression of cyclic nucleotide phosphodiesterase 3B, affecting genes responsible for Tr cell homeostasis.
PMID	17220874
GEOID	GSE7280,GSE7770,GSE7773
AUTHORS	Gavin MA,Rasmussen JP,Fontenot JD,Vasta V,Manganiello VC,Beavo JA,Rudensky AY
CONTRIBUTOR	Jessica Robertson
CONTRIBUTOR_ORG	MSigDB Team
EXACT_SOURCE	Supplementary Fig 7D
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	2210023C10Rik,AI606844,BB030901,BB223018,BB235011,BE686007,BF714312,D730035F11Rik,Ian6,Kif1b,Tmie
GENE_SYMBOLS	YARS2,,,,,STK38,,,GIMAP6,KIF1B,TMIE
FOUNDER_NAMES