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<MSIGDB BUILD_DATE="Jan 29, 2026" VERSION="2026.1.Hs" NAME="export">
    <GENESET STANDARD_NAME="GENTILE_UV_LOW_DOSE_UP" SYSTEMATIC_NAME="M17864" HISTORICAL_NAMES="" PMID="12907719" AUTHORS="Gentile M,Latonen L,Laiho M" GEOID="GSE713" EXACT_SOURCE="Table 1" GENESET_LISTING_URL="" EXTERNAL_DETAILS_URL="" CHIP="HUMAN_SEQ_ACCESSION" CONTRIBUTOR="John Newman" CONTRIBUTOR_ORG="University of Washington" DESCRIPTION_BRIEF="Selected genes up-regulated in WS1 (fibroblast) in response to irradiation with low dose UV-C." DESCRIPTION_FULL="DNA damage caused by UV radiation initiates cellular recovery mechanisms, which involve activation of DNA damage response pathways, cell cycle arrest and apoptosis. To assess cellular transcriptional responses to UVC-induced DNA damage we compared time course responses of human skin fibroblasts to low and high doses of UVC radiation known to induce a transient cellular replicative arrest or apoptosis, respectively. UVC radiation elicited &gt;3-fold changes in 460 out of 12,000 transcripts and 89% of these represented downregulated transcripts. Only 5% of the regulated genes were common to both low and high doses of radiation. Cells inflicted with a low dose of UVC exhibited transcription profiles demonstrating transient regulation followed by recovery, whereas the responses were persistent after the high dose. A detailed clustering analysis and functional classification of the targets implied regulation of biologically divergent responses and suggested involvement of transcriptional and translational machinery, inflammatory, anti-proliferative and anti-angiogenic responses. The data support the notion that UVC radiation induces prominent, dose-dependent downregulation of transcription. However, the data strongly suggest that transcriptional repression is also target gene selective. Furthermore, the results demonstrate that dose-dependent induction of cell cycle arrest and apoptosis by UVC radiation are transcriptionally highly distinct responses." TAGS="" MEMBERS="AA156240,AA195301,AA203213,AB000584,AF059617,AF095448,AI885852,AJ001019,AL031432,D38305,D88827,D90070,HG172-HT3924,J03826,J03909,M11717,M59830,M74093,U03106,U09303,U14575,U61836,U72649,U89896,W28948,X57522,X58377,X70683,Y07595" MEMBERS_SYMBOLIZED="BTG2,CCDC86,CCNE1,CDKN1A,CSNK1G2,EFNB1,FDXR,GDF15,GPRC5A,GTF2H4,H2AC18,HSPA1A,HSPA1B,IL11,ISG15,PLK2,PMAIP1,PPP1R8,RSL1D1,SMOX,SOX4,SYF2,TAP1,TOB1,ZNF263" MEMBERS_EZID="10127,10140,1026,10769,1455,1947,2232,25949,26156,2968,3303,3304,3589,5366,54498,5511,6659,6890,7832,79080,8337,898,9052,9518,9636" MEMBERS_MAPPING="AA156240,null,null|AA195301,CCDC86,79080|AA203213,ISG15,9636|AB000584,GDF15,9518|AF059617,PLK2,10769|AF095448,GPRC5A,9052|AI885852,H2AC18,8337|AJ001019,null,null|AL031432,SYF2,25949|D38305,TOB1,10140|D88827,ZNF263,10127|D90070,PMAIP1,5366|HG172-HT3924,null,null|J03826,FDXR,2232|J03909,null,null|M11717,HSPA1A,3303|M59830,HSPA1B,3304|M74093,CCNE1,898|U03106,CDKN1A,1026|U09303,EFNB1,1947|U14575,PPP1R8,5511|U61836,SMOX,54498|U72649,BTG2,7832|U89896,CSNK1G2,1455|W28948,RSL1D1,26156|X57522,TAP1,6890|X58377,IL11,3589|X70683,SOX4,6659|Y07595,GTF2H4,2968" FILTERED_BY_SIMILARITY="" FOUNDER_NAMES="" REFINEMENT_DATASETS="" VALIDATION_DATASETS="" CATEGORY_CODE="C2" ORGANISM="Homo sapiens" SUB_CATEGORY_CODE="CGP"/>
</MSIGDB>
