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<MSIGDB BUILD_DATE="Jan 29, 2026" VERSION="2026.1.Hs" NAME="export">
    <GENESET STANDARD_NAME="GENTILE_UV_RESPONSE_CLUSTER_D5" SYSTEMATIC_NAME="M13814" HISTORICAL_NAMES="" PMID="12907719" AUTHORS="Gentile M,Latonen L,Laiho M" GEOID="GSE713" EXACT_SOURCE="Table 2S: Cluster d5" GENESET_LISTING_URL="" EXTERNAL_DETAILS_URL="" CHIP="HUMAN_SEQ_ACCESSION" CONTRIBUTOR="John Newman" CONTRIBUTOR_ORG="University of Washington" DESCRIPTION_BRIEF="Cluster d5: genes progressively down-regulated in WS1 cells (fibroblast) through 18 h after irradiation with high dose UV-C." DESCRIPTION_FULL="DNA damage caused by UV radiation initiates cellular recovery mechanisms, which involve activation of DNA damage response pathways, cell cycle arrest and apoptosis. To assess cellular transcriptional responses to UVC-induced DNA damage we compared time course responses of human skin fibroblasts to low and high doses of UVC radiation known to induce a transient cellular replicative arrest or apoptosis, respectively. UVC radiation elicited &gt;3-fold changes in 460 out of 12,000 transcripts and 89% of these represented downregulated transcripts. Only 5% of the regulated genes were common to both low and high doses of radiation. Cells inflicted with a low dose of UVC exhibited transcription profiles demonstrating transient regulation followed by recovery, whereas the responses were persistent after the high dose. A detailed clustering analysis and functional classification of the targets implied regulation of biologically divergent responses and suggested involvement of transcriptional and translational machinery, inflammatory, anti-proliferative and anti-angiogenic responses. The data support the notion that UVC radiation induces prominent, dose-dependent downregulation of transcription. However, the data strongly suggest that transcriptional repression is also target gene selective. Furthermore, the results demonstrate that dose-dependent induction of cell cycle arrest and apoptosis by UVC radiation are transcriptionally highly distinct responses." TAGS="" MEMBERS="AA418437,AB004884,AB007855,AB023155,AB023198,AF012108,AF023917,AF070644,AI950382,AL050265,AW005997,D28423,D30037,D83004,D83785,D86550,D86961,HG2855-HT2995,HG3502-HT3696,J03161,L07919,L25931,L35249,L48692,M37825,S62138,U43142,U43899,W21884,X06409,X16665,X16706,X53390,X78992,X79201,X81889,X84709,X98263,Z24725" MEMBERS_SYMBOLIZED="ATP6V1B2,DLX2,DUSP11,DYRK1A,FADD,FERMT2,FGF5,FOSL2,HOXB2,JMJD6,LBR,LHFPL2,MAML1,MLX,MPHOSPH6,MRFAP1L1,NAV3,NCOA3,PIKFYVE,PITPNB,PKP4,PNO1,PXDC1,SRF,SRSF3,SS18,STAM,TARDBP,TLK2,UBE2N,UBTF,VEGFC,WBP1L,ZFP36L2,ZHX3" MEMBERS_EZID="10184,10200,10979,11011,114932,1746,1859,200576,221749,2250,23051,23210,23435,2355,23760,3212,3930,526,54838,56902,6428,6722,6760,678,6945,7334,7343,7424,8027,8202,8446,8502,8772,89795,9794" MEMBERS_MAPPING="AA418437,PXDC1,221749|AB004884,TLK2,11011|AB007855,ZHX3,23051|AB023155,NAV3,89795|AB023198,PIKFYVE,200576|AF012108,NCOA3,8202|AF023917,DUSP11,8446|AF070644,WBP1L,54838|AI950382,JMJD6,23210|AL050265,TARDBP,23435|AW005997,MLX,6945|D28423,SRSF3,6428|D30037,PITPNB,23760|D83004,UBE2N,7334|D83785,MAML1,9794|D86550,DYRK1A,1859|D86961,LHFPL2,10184|HG2855-HT2995,null,null|HG3502-HT3696,null,null|J03161,SRF,6722|L07919,DLX2,1746|L25931,LBR,3930|L35249,ATP6V1B2,526|L48692,PNO1,56902|M37825,FGF5,2250|S62138,null,null|U43142,VEGFC,7424|U43899,STAM,8027|W21884,MRFAP1L1,114932|X06409,null,null|X16665,HOXB2,3212|X16706,FOSL2,2355|X53390,UBTF,7343|X78992,ZFP36L2,678|X79201,SS18,6760|X81889,PKP4,8502|X84709,FADD,8772|X98263,MPHOSPH6,10200|Z24725,FERMT2,10979" FILTERED_BY_SIMILARITY="" FOUNDER_NAMES="" REFINEMENT_DATASETS="" VALIDATION_DATASETS="" CATEGORY_CODE="C2" ORGANISM="Homo sapiens" SUB_CATEGORY_CODE="CGP"/>
</MSIGDB>
