STANDARD_NAME GENTLES_LEUKEMIC_STEM_CELL_UP SYSTEMATIC_NAME M2542 COLLECTION C2:CGP MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GENTLES_LEUKEMIC_STEM_CELL_UP NAMESPACE Human_RefSeq DESCRIPTION_BRIEF Genes up-regulated in LSC (leukemic stem) cells compared to LPC (leukemia progenitor) cells from AML (acute myeloid leukemia) tumor samples. DESCRIPTION_FULL In many cancers, specific subpopulations of cells appear to be uniquely capable of initiating and maintaining tumors. The strongest support for this cancer stem cell model comes from transplantation assays in immunodeficient mice, which indicate that human acute myeloid leukemia (AML) is driven by self-renewing leukemic stem cells (LSCs). This model has significant implications for the development of novel therapies, but its clinical relevance has yet to be determined. PMID 21177505 GEOID GSE24006 AUTHORS Gentles AJ,Plevritis SK,Majeti R,Alizadeh AA CONTRIBUTOR Andrew Gentles CONTRIBUTOR_ORG Stanford University EXACT_SOURCE Table 2S: Mean FC > 0 (red) FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS NM_000201,NM_000392,NM_001003927,NM_001005463,NM_001018009,NM_001025109,NM_001077484,NM_001130687,NM_001131005,NM_001142472,NM_001145459,NM_001165,NM_002126,NM_002341,NM_004666,NM_006867,NM_007351,NM_014181,NM_015002,NM_015559,NM_015660,NM_016217,NM_017439,NM_024711,NM_024768,NM_032090,NM_032295,NM_052913,NM_153236,XM_001126245,XM_001716710 GENE_SYMBOLS ICAM1,ABCC2,EVI2A,EBF3,SH3BP5,CD34,SLC38A1,GUCY1A1,MEF2C,FCMR,HOPX,BIRC3,HLF,LTB,VNN1,RBPMS,MMRN1,LGALSL,FBXO21,SETBP1,GIMAP2,HECA,GSAP,GIMAP6,EFCC1,PCDHGA10,SLC37A3,TMEM200A,GIMAP7,, FOUNDER_NAMES