STANDARD_NAME GOBP_CANONICAL_WNT_SIGNALING_PATHWAY_INVOLVED_IN_HEART_DEVELOPMENT SYSTEMATIC_NAME M24276 COLLECTION C5:GO:BP MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GOBP_CANONICAL_WNT_SIGNALING_PATHWAY_INVOLVED_IN_HEART_DEVELOPMENT NAMESPACE Human_NCBI_Gene_ID DESCRIPTION_BRIEF The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that contributes to the progression of the heart over time. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes. [GOC:mtg_heart] DESCRIPTION_FULL PMID GEOID AUTHORS CONTRIBUTOR Gene Ontology CONTRIBUTOR_ORG Gene Ontology Consortium EXACT_SOURCE GO:0061316 FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL http://amigo.geneontology.org/amigo/term/GO:0061316 SOURCE_MEMBERS 1499,22943,3516,406980,7478,89780 GENE_SYMBOLS CTNNB1,DKK1,RBPJ,MIR19B1,WNT8A,WNT3A FOUNDER_NAMES