STANDARD_NAME GOLDRATH_ANTIGEN_RESPONSE SYSTEMATIC_NAME M11884 COLLECTION C2:CGP MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GOLDRATH_ANTIGEN_RESPONSE NAMESPACE AFFY_MG_U74 DESCRIPTION_BRIEF Genes up-regulated at the peak of an antigen response of naive CD8+ [GeneID=925;926] T-cells. DESCRIPTION_FULL Naive T cells proliferate independently of cognate antigen when introduced into lymphopenic hosts. Lymphopenia-induced proliferation depends on low-affinity MHC/self-peptide complexes and on IL-7. To elucidate the intracellular signals mediating this proliferation, we analyzed changes in gene expression in naive CD8+ T cells at different times after their transfer into a lymphopenic environment. The genes induced in response to lymphopenia were largely an attenuated subset of those turned up by full antigenic stimulation, including genes related to cell cycling, whereas excluding genes specifically associated with effector activity. After the initial phase of proliferation in an empty compartment, the naive T cells adopted a stable pattern of gene expression similar to that of antigen-experienced memory cells. Thus, T cells proliferating in lymphopenic hosts do not exhibit a unique gene-expression profile, instead relying on traditional signals for this antigen-independent proliferation; this process ultimately results in differentiation to authentic memory cells. PMID 15548615 GEOID GSE1921 AUTHORS Goldrath AW,Luckey CJ,Park R,Benoist C,Mathis D CONTRIBUTOR Arthur Liberzon CONTRIBUTOR_ORG MSigDB Team EXACT_SOURCE Table 1S FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS 100022_at,100046_at,100062_at,100116_at,100123_f_at,100124_r_at,100128_at,100133_at,100151_at,100156_at,100322_at,100325_at,100397_at,100468_g_at,100522_s_at,100539_at,100565_at,100569_at,100584_at,100600_at,100612_at,100616_at,100621_at,100682_f_at,100721_f_at,100885_at,100955_at,100960_g_at,100986_at,100998_at,101040_at,101044_at,101047_at,101054_at,101065_at,101077_at,101123_at,101144_at,101214_f_at,101254_at,101326_at,101331_f_at,101372_at,101458_at,101521_at,101561_at,101589_at,101633_at,101640_f_at,101708_at,101718_f_at,101848_g_at,101869_s_at,101870_at,101871_f_at,101877_at,101889_s_at,101898_s_at,101917_at,101954_at,101972_at,101973_at,102001_at,102012_at,102037_at,102064_at,102076_at,102156_f_at,102208_at,102354_at,102372_at,102403_at,102407_at,102424_at,102561_at,102585_f_at,102632_at,102644_at,102645_at,102655_at,102656_at,102718_at,102721_at,102722_g_at,102752_at,102823_at,102824_g_at,102839_at,102843_s_at,102860_at,102877_at,102885_at,102914_s_at,102920_at,102934_s_at,102935_at,102955_at,102970_at,102976_at,102995_s_at,103005_s_at,103016_s_at,103017_at,103024_at,103064_at,103071_at,103074_f_at,103089_at,103201_at,103203_f_at,103204_r_at,103207_at,103237_at,103260_at,103270_at,103299_at,103308_at,103340_at,103349_at,103362_at,103416_at,103443_at,103444_at,103503_at,103507_at,103509_at,103518_at,103534_at,103553_at,103662_at,103690_at,103821_at,103886_at,103891_i_at,103930_at,104056_at,104097_at,104108_at,104173_at,104252_at,104304_r_at,104308_at,104322_at,104333_at,104383_at,104388_at,104407_at,104423_at,104435_at,104522_at,104527_at,104533_at,104534_at,104547_at,104598_at,104644_at,104701_at,104725_at,160069_at,160084_at,160091_at,160100_at,160106_at,160159_at,160167_at,160183_f_at,160188_at,160233_at,160253_at,160255_at,160324_at,160487_at,160496_s_at,160501_at,160517_at,160543_at,160628_at,160638_at,160648_at,160699_at,160755_at,160785_at,160845_at,160905_s_at,160973_at,161000_i_at,161004_at,161110_at,161121_f_at,161147_f_at,161172_f_at,161332_f_at,161522_i_at,161525_f_at,161650_at,161666_f_at,161703_f_at,161856_f_at,161911_f_at,161968_f_at,161980_f_at,161983_f_at,162195_i_at,162313_f_at,162457_f_at,162475_f_at,92217_s_at,92316_f_at,92534_at,92539_at,92551_at,92574_at,92639_at,92642_at,92676_at,92694_at,92737_at,92768_s_at,92770_at,92771_at,92773_at,92790_at,92807_at,92847_s_at,92854_at,92858_at,92866_at,92904_at,93013_at,93019_at,93023_f_at,93026_at,93037_i_at,93038_f_at,93041_at,93043_at,93077_s_at,93099_f_at,93184_at,93227_f_at,93236_s_at,93237_s_at,93250_r_at,93258_at,93315_at,93323_at,93358_at,93364_at,93380_at,93397_at,93437_f_at,93441_at,93453_at,93462_at,93465_at,93471_at,93495_at,93497_at,93573_at,93575_at,93593_f_at,93638_s_at,93676_at,93678_s_at,93679_at,93753_at,93754_at,93758_at,93787_f_at,93804_at,93806_at,93810_at,93843_at,93869_s_at,93893_f_at,93894_f_at,93898_at,93904_f_at,93931_at,93975_at,93984_at,94018_at,94138_s_at,94146_at,94173_at,94191_at,94217_f_at,94256_at,94285_at,94288_at,94294_at,94322_at,94360_at,94384_at,94401_s_at,94486_at,94492_at,94508_at,94526_at,94556_at,94725_f_at,94759_at,94768_at,94781_at,94784_at,94953_at,94963_at,94971_at,95016_at,95019_at,95032_at,95118_r_at,95137_at,95320_at,95333_at,95363_at,95380_at,95406_at,95419_at,95465_s_at,95474_at,95517_i_at,95527_at,95542_at,95549_at,95555_at,95561_at,95612_at,95613_at,95614_at,95629_at,95650_at,95706_at,95722_at,95753_at,95755_at,95894_at,96019_at,96041_at,96060_at,96065_at,96081_at,96115_at,96135_at,96285_at,96319_at,96353_at,96627_at,96672_at,96710_at,96723_f_at,96735_at,96751_at,96772_at,96784_at,96785_at,96884_at,96912_s_at,96947_at,96971_f_at,96972_f_at,97013_f_at,97061_g_at,97113_at,97164_at,97238_at,97248_at,97268_i_at,97269_f_at,97295_at,97320_at,97327_at,97364_at,97411_at,97426_at,97444_at,97468_at,97527_at,97551_at,97563_f_at,97566_f_at,97567_f_at,97718_at,97751_f_at,97819_at,97825_at,97828_at,97895_f_at,97896_r_at,97909_at,97915_at,97918_at,97949_at,98002_at,98025_at,98033_at,98042_at,98059_s_at,98098_at,98240_at,98392_at,98405_at,98406_at,98437_at,98469_at,98471_f_at,98489_at,98505_i_at,98524_f_at,98532_at,98600_at,98836_at,98982_at,98996_at,99051_at,99073_at,99175_at,99186_at,99334_at,99366_at,99398_at,99405_at,99446_at,99457_at,99475_at,99522_at,99541_at,99566_at,99578_at,99580_s_at,99586_at,99632_at,99669_at,99777_s_at,99816_at,99917_at,AFFX-GapdhMur/M32599_3_at,AFFX-GapdhMur/M32599_M_at GENE_SYMBOLS CISH,MTHFD2,MCM3,PCLAF,ITGB1,ITGB1,CDK1,FYN,SERINC3,MCM5,,LILRB4,TYROBP,LYL1,TCEAL9,ACOT7,GNPDA1,ANXA2,ANXA4,CD24,RRM1,CENPA,RNH1,,IGHV1-58,NEK2,UBE2T,S100A13,FHL2,HLA-DQB1,CAPN2,ALAD,,CD74,PCNA,SLC4A1,ITM2B,IL18R1,GAPDH,RAN,IGHV2-26,IGKV4-1,TRIP13,WEE1,BIRC5,MT2A,HMGN2,IGKV5-2,,MYO1F,,SP100,HBB,IGHG1,,SLC31A1,RORA,HLA-A,IL2RA,H2AZ1,NAPSA,CITED2,RRM2,SKAP2,MAPRE2,CASP1,,,ST3GAL6,TCF19,JCHAIN,CDC45,CMA1,CCL3,,,ASPM,MDFIC,EEA1,ITGA4,ITGA4,CCR5,,,CYFIP1,IGHG1,IGHG1,PLSCR1,,SERPINA3,GZMB,,BCL2A1,TTC39B,CDC25C,CDC25C,NFIL3,PSMC3IP,BRCA1,GZMA,CD44,CD68,,ADAM8,CHEK1,TOPBP1,TAF9,CD48,TTK,E2F8,E2F8,POLA1,MXD3,DOCK5,GTSE1,PLD4,MIS18BP1,RHD,LYN,PTGER4,MAPK6,CRYBG1,DNA2,PLCG2,ADGRE1,TNFRSF9,,,MCM10,NCF4,LAT2,CDC6,REEP5,ELL2,N4BP1,CCDC50,BUB1,DENND5A,MS4A1,,POLR3K,ITGAX,CKAP2,,CRMP1,CCL15,ALCAM,DTL,IGSF10,ITSN1,RAD51,PIM1,PGM2,DHFR,DUSP1,KIF4A,BHLHE40,RHOQ,GMNN,ODC1,PGAM1,EFHD2,CAPG,CCNB1,NUP62,TMED7,NUDT4,AK3,IFITM3,AHNAK,RPA3,MYL4,MCM3,KIF20A,LMNB1,SNX3,GCAT,CDKN2C,FIGNL1,CDCA5,KIF2C,ARHGAP21,SPDL1,RNF227,CIP2A,NUSAP1,,TKTL1,S100A13,CMC2,,,,,,GADD45B,ANXA1,,,,BAG3,,,,,PGLYRP1,LILRB4,IGLC1,GEM,S100A10,LIG1,SDHD,AURKA,CA2,RUNX2,CHIA,IRF4,ALAS2,S100A6,ZNF207,,KPNA2,TXN,M6PR,RAB11A,SLPI,HLA-DQA1,PRDM1,ID2,H2AX,H3C4,MGST1,ANXA1,ANXA1,MCM4,NPTN,,PLK1,TBL2,IGKV4-1,TYMS,TYMS,HMGB2,HMBS,MAP2K3,PLP2,EIF1AX,CTNNA1,KLRB1,CCR2,,,ROM1,TTC39B,BATF3,SLC4A7,PRDX4,C3,MT1A,GGH,EMP3,IGLC6,RAD51AP1,KLRK1,KLRK1,LITAF,ECH1,INCENP,MRPL18,SLC2A3,SH3BGRL,CTSD,DHRS1,BCL2A1,,,SGCB,IGHV1-69-2,PRF1,ERRFI1,ATP5IF1,UBL3,FUT7,CCL4,CXCR3,F2RL3,CDCA3,CLIC4,HLA-DRB5,H1-2,CCNB2,SQLE,HPF1,IER3,HEMGN,LRRC59,DSTN,TMEM126A,CISD1,SNX10,,SLC25A53,RAD21,,IQGAP3,RACGAP1,VCL,CDKN3,NRP1,GSTT1,PRC1,KIF22,TMEM97,KLRG1,IL18RAP,GZMM,CD244,C4orf3,H1-0,TMEM37,F2R,C6orf89,CHAF1A,TPM4,PRIM2,UNC119,SYCE2,RFC5,TMEM30A,CBX5,TRAPPC1,SNU13,LGALS3,GLRX,NCAPH,YBX3,FANCM,SYPL1,RBM3,SERPINB6,LXN,TK1,REEP5,ABRACL,MYADM,CDC20,TMEM14C,EBP,HOPX,H2AZ2,SSX2IP,STARD10,ARL5A,PRIM1,ANLN,KANK3,CARHSP1,,ETFB,,,,YWHAQ,FASLG,RNASEH2B,TACC3,DBI,KRTCAP2,KRTCAP2,CDCA8,SLC39A4,FEN1,ASF1B,ECT2,EMP1,IFI30,CKS1B,CKS2,HIP1R,IGHV1-58,,,CTLA4,,GSTO1,PERP,SIVA1,HAT1,HAT1,STMN1,PLEKHB2,RELL1,FGL2,IRF8,EVI2A,PLBD1,SCPEP1,LMNA,CA1,IL12RB1,LAG3,SERPINB9,CCL5,CASP3,AURKB,KIFC1,DLGAP5,CPOX,,CDK2AP1,S100A11,PDCD1,TMPO,PLK4,S100A4,CCNF,GNG10,CCNA2,IFNG,SLC66A3,GZMK,IGKV2D-30,MS4A1,MKI67,SOCS2,HASPIN,KIF11,TPI1,TOP2A,UGT1A10,CST3,MAD2L1,LGALS1,HAUS6,HSPA2,EZH2,, FOUNDER_NAMES