STANDARD_NAME GOLDRATH_EFF_VS_MEMORY_CD8_TCELL_UP SYSTEMATIC_NAME M3041 COLLECTION C7:IMMUNESIGDB MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GOLDRATH_EFF_VS_MEMORY_CD8_TCELL_UP NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes up-regulated in comparison of effector CD8 T cells versus memory CD8 T cells. DESCRIPTION_FULL The only cells of the hematopoietic system that undergo self-renewal for the lifetime of the organism are long-term hematopoietic stem cells and memory T and B cells. To determine whether there is a shared transcriptional program among these self-renewing populations, we first compared the gene-expression profiles of naïve, effector and memory CD8(+) T cells with those of long-term hematopoietic stem cells, short-term hematopoietic stem cells, and lineage-committed progenitors. Transcripts augmented in memory CD8(+) T cells relative to naïve and effector T cells were selectively enriched in long-term hematopoietic stem cells and were progressively lost in their short-term and lineage-committed counterparts. Furthermore, transcripts selectively decreased in memory CD8(+) T cells were selectively down-regulated in long-term hematopoietic stem cells and progressively increased with differentiation. To confirm that this pattern was a general property of immunologic memory, we turned to independently generated gene expression profiles of memory, naïve, germinal center, and plasma B cells. Once again, memory-enriched and -depleted transcripts were also appropriately augmented and diminished in long-term hematopoietic stem cells, and their expression correlated with progressive loss of self-renewal function. Thus, there appears to be a common signature of both up- and down-regulated transcripts shared between memory T cells, memory B cells, and long-term hematopoietic stem cells. This signature was not consistently enriched in neural or embryonic stem cell populations and, therefore, appears to be restricted to the hematopoeitic system. These observations provide evidence that the shared phenotype of self-renewal in the hematopoietic system is linked at the molecular level. PMID 16492737 GEOID AUTHORS Luckey CJ,Bhattacharya D,Goldrath AW,Weissman IL,Benoist C,Mathis D CONTRIBUTOR Jernej Godec CONTRIBUTOR_ORG Dana-Farber Cancer Institute EXACT_SOURCE GSE1000002_1582_200_UP FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS ADAM8,AK3,ANLN,ANXA1,ANXA2,ANXA4,ASF1B,ASPM,ATP6V1A,ATPIF1,AURKA,AURKB,BATF3,BHLHE40,BIRC5,BRCA1,BUB1,C16orf61,C3,CA2,CAPG,CASP3,CBX1,CCDC99,CCNA2,CCNB2,CCNF,CCR2,CD244,CD99,CDC20,CDC25C,CDC45,CDC6,CDCA3,CDCA8,CDK1,CDKN2C,CDKN3,CENPA,CHAF1A,CHEK1,CISD1,CKAP5,CKS1B,CKS2,CLCN5,CRMP1,CSDA,DBI,DCK,DEGS1,DHFR,DHRS1,DLGAP5,DNA2,DNAJC1,DOCK5,DTL,DUSP2,E2F8,ECT2,EGR1,EMP1,EMP3,EZH2,F2RL3,FANCM,FDFT1,FGL2,FKBP5,FPR2,GABARAPL1,GALNT3,GEM,GGH,GMNN,GTF2B,GZMA,GZMB,GZMK,H1F0,H2AFX,H2AFZ,HIST3H3,HMGB3,HP,IDI1,IFI27L2,IFITM3,IFNG,INCENP,IQGAP3,IRF4,IRF8,ISG20,ITGAX,KIAA0101,KIAA1524,KIF11,KIF20A,KIF22,KIF23,KIF2C,KIF4A,KLRG1,KPNA2,LAG3,LGALS1,LGALS3,LIG1,LITAF,LMNB1,LSP1,LXN,LYN,MAD2L1,MAPK6,MCM10,MIS18BP1,MKI67,MPEG1,MRPL18,MT1E,MT2A,MTM1,MYADM,NCAPH,NDRG1,NEK2,NFYB,NR4A1,NRP1,NUDT4,NUP62,NUSAP1,PDCD1,PDK3,PERP,PLAC8,PLK4,POLA1,POLE2,PRC1,PRDX4,PRIM1,PSMA5,RAD51,RAD51AP1,RAN,RBL1,RFC5,RHD,RNASEH2B,ROM1,RRM1,RRM2,S100A10,S100A4,S100A8,SERPINB9,SIVA1,SMARCC1,SMC2,SNX10,SNX3,SQLE,STMN1,STT3B,SUN1,SUZ12,SYCE2,SYPL1,TACC3,TAGLN2,TCF19,TIPIN,TK1,TKTL1,TMEM14C,TMEM50B,TMEM97,TMPO,TOP2A,TSPAN32,TTK,TUBA1A,TUBA1B,TUBA1C,TUBB3,TXN,TYMS,TYROBP,UBE2N,UBE2T,UCHL5,UCK2,VPS45,WEE1,XBP1 GENE_SYMBOLS ADAM8,AK3,ANLN,ANXA1,ANXA2,ANXA4,ASF1B,ASPM,ATP6V1A,ATP5IF1,AURKA,AURKB,BATF3,BHLHE40,BIRC5,BRCA1,BUB1,CMC2,C3,CA2,CAPG,CASP3,CBX1,SPDL1,CCNA2,CCNB2,CCNF,CCR2,CD244,CD99,CDC20,CDC25C,CDC45,CDC6,CDCA3,CDCA8,CDK1,CDKN2C,CDKN3,CENPA,CHAF1A,CHEK1,CISD1,CKAP5,CKS1B,CKS2,CLCN5,CRMP1,YBX3,DBI,DCK,DEGS1,DHFR,DHRS1,DLGAP5,DNA2,DNAJC1,DOCK5,DTL,DUSP2,E2F8,ECT2,EGR1,EMP1,EMP3,EZH2,F2RL3,FANCM,FDFT1,FGL2,FKBP5,FPR2,GABARAPL1,GALNT3,GEM,GGH,GMNN,GTF2B,GZMA,GZMB,GZMK,H1-0,H2AX,H2AZ1,H3-4,HMGB3,HP,IDI1,IFI27L2,IFITM3,IFNG,INCENP,IQGAP3,IRF4,IRF8,ISG20,ITGAX,PCLAF,CIP2A,KIF11,KIF20A,KIF22,KIF23,KIF2C,KIF4A,KLRG1,KPNA2,LAG3,LGALS1,LGALS3,LIG1,LITAF,LMNB1,LSP1,LXN,LYN,MAD2L1,MAPK6,MCM10,MIS18BP1,MKI67,MPEG1,MRPL18,MT1E,MT2A,MTM1,MYADM,NCAPH,NDRG1,NEK2,NFYB,NR4A1,NRP1,NUDT4,NUP62,NUSAP1,PDCD1,PDK3,PERP,PLAC8,PLK4,POLA1,POLE2,PRC1,PRDX4,PRIM1,PSMA5,RAD51,RAD51AP1,RAN,RBL1,RFC5,RHD,RNASEH2B,ROM1,RRM1,RRM2,S100A10,S100A4,S100A8,SERPINB9,SIVA1,SMARCC1,SMC2,SNX10,SNX3,SQLE,STMN1,STT3B,SUN1,SUZ12,SYCE2,SYPL1,TACC3,TAGLN2,TCF19,TIPIN,TK1,TKTL1,TMEM14C,TMEM50B,TMEM97,TMPO,TOP2A,TSPAN32,TTK,TUBA1A,TUBA1B,TUBA1C,TUBB3,TXN,TYMS,TYROBP,UBE2N,UBE2T,UCHL5,UCK2,VPS45,WEE1,XBP1 FOUNDER_NAMES