STANDARD_NAME	GOLDRATH_IMMUNE_MEMORY
SYSTEMATIC_NAME	M10845
COLLECTION	C2:CGP
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GOLDRATH_IMMUNE_MEMORY
NAMESPACE	AFFY_MG_U74
DESCRIPTION_BRIEF	'Memory genes' expressed uniquely in CD8+ [GeneID=925] memory T lymphocytes (compared with effector or naive cells)
DESCRIPTION_FULL	Naive T cells proliferate independently of cognate antigen when introduced into lymphopenic hosts. Lymphopenia-induced proliferation depends on low-affinity MHC/self-peptide complexes and on IL-7. To elucidate the intracellular signals mediating this proliferation, we analyzed changes in gene expression in naive CD8+ T cells at different times after their transfer into a lymphopenic environment. The genes induced in response to lymphopenia were largely an attenuated subset of those turned up by full antigenic stimulation, including genes related to cell cycling, whereas excluding genes specifically associated with effector activity. After the initial phase of proliferation in an empty compartment, the naive T cells adopted a stable pattern of gene expression similar to that of antigen-experienced memory cells. Thus, T cells proliferating in lymphopenic hosts do not exhibit a unique gene-expression profile, instead relying on traditional signals for this antigen-independent proliferation; this process ultimately results in differentiation to authentic memory cells.
PMID	15548615
GEOID	GSE1921
AUTHORS	Goldrath AW,Luckey CJ,Park R,Benoist C,Mathis D
CONTRIBUTOR	Kate Stafford
CONTRIBUTOR_ORG	MSigDB Team
EXACT_SOURCE	Table 4S
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	100606_at,100948_at,100979_at,101015_s_at,101313_r_at,102114_f_at,102272_at,102628_at,102910_at,103223_at,103551_at,103686_at,103693_at,103767_f_at,103804_at,103916_at,104004_at,104092_at,104298_at,104328_at,104580_at,104614_at,104714_at,104728_at,104735_at,104761_at,160320_at,160611_at,160685_at,160793_at,160941_at,160965_at,161023_at,92198_s_at,92214_at,92262_at,92302_at,92323_at,92356_at,92460_at,92778_i_at,92779_f_at,92780_f_at,93232_at,93738_at,93880_at,93928_f_at,93953_at,93994_at,94186_at,94266_at,94394_at,95015_at,95313_at,95508_at,95550_at,95709_at,96038_at,96119_s_at,96167_at,96198_at,96486_at,96525_at,96676_at,96961_at,97393_at,97525_at,97533_at,98432_at,98527_at,98892_at,99076_at,99491_at,99514_at
GENE_SYMBOLS	PRNP,ANKH,RNF138,IFNAR2,,,CD160,FHIT,ABCB1,PRKCE,PLEKHA5,MCOLN2,TIRAP,RRM2B,RECK,LDAF1,GOLIM4,USP48,CIPC,AQP9,PLCD1,GPC1,DOCK9,PROS1,KCTD12,ANTXR2,SORBS1,CYP4V2,,POU6F1,PDE8A,RASA4B,IL15RA,CD55,CTSW,ZMAT3,SOS2,MAPK12,PTPN22,SEMA4F,,,,TMEM141,SLC2A1,EOMES,,PRSS12,CHPT1,TRAF1,HCFC1R1,RRAS,,F2R,NCKAP1,RPGR,VKORC1,RNASE4,ANGPTL4,BAG3,PRKCZ,,IL10RA,CHCHD7,PCGF2,VRK1,GK,FCGRT,PALD1,ECI1,LPIN1,NR1D2,IL10RB,
FOUNDER_NAMES