STANDARD_NAME GRADE_COLON_AND_RECTAL_CANCER_DN SYSTEMATIC_NAME M15780 COLLECTION C2:CGP MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GRADE_COLON_AND_RECTAL_CANCER_DN NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Down-regulated genes in both rectal and colon carcinoma compared to normal mucosa samples. DESCRIPTION_FULL To characterize patterns of global transcriptional deregulation in primary colon carcinomas, we did gene expression profiling of 73 tumors [Unio Internationale Contra Cancrum stage II (n = 33) and stage III (n = 40)] using oligonucleotide microarrays. For 30 of the tumors, expression profiles were compared with those from matched normal mucosa samples. We identified a set of 1,950 genes with highly significant deregulation between tumors and mucosa samples (P < 1e-7). A significant proportion of these genes mapped to chromosome 20 (P = 0.01). Seventeen genes had a >5-fold average expression difference between normal colon mucosa and carcinomas, including up-regulation of MYC and of HMGA1, a putative oncogene. Furthermore, we identified 68 genes that were significantly differentially expressed between lymph node-negative and lymph node-positive tumors (P < 0.001), the functional annotation of which revealed a preponderance of genes that play a role in cellular immune response and surveillance. The microarray-derived gene expression levels of 20 deregulated genes were validated using quantitative real-time reverse transcription-PCR in >40 tumor and normal mucosa samples with good concordance between the techniques. Finally, we established a relationship between specific genomic imbalances, which were mapped for 32 of the analyzed colon tumors by comparative genomic hybridization, and alterations of global transcriptional activity. Previously, we had conducted a similar analysis of primary rectal carcinomas. The systematic comparison of colon and rectal carcinomas revealed a significant overlap of genomic imbalances and transcriptional deregulation, including activation of the Wnt/beta-catenin signaling cascade, suggesting similar pathogenic pathways. PMID 17210682 GEOID AUTHORS Grade M,Hörmann P,Becker S,Hummon AB,Wangsa D,Varma S,Simon R,Liersch T,Becker H,Difilippantonio MJ,Ghadimi BM,Ried T CONTRIBUTOR Jessica Robertson CONTRIBUTOR_ORG MSigDB Team EXACT_SOURCE Table 5S: Colon < 1 & Rectum < 1 FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS AKR7A2,AOC2,B3GALT3,C14orf132,C20orf100,C4.4A,C8orf1,CA5A,CACNA2D2,CBS,CCR9,CD28,CHST8,COL4A5,CPN2,CRK7,CX3CR1,DAP,DF,DHPS,DKFZp564O0823,FABP7,FHL1,FKRP,FLJ12800,FLJ32499,FLJ37478,FLJ90723,GALNAC4S-6ST,GFI1,GGA1,GNA11,GNPDA1,GPC1,GPR87,GREB1,GTF3C4,HCCA2,HIC2,HMG2L1,ITPKB,JAM3,KIAA0841,KIAA1018,KRTHB4,LDB2,LGALS2,LOC112476,LOC126208,LOC139886,LOC201895,LOC220074,LOC51152,LOC63929,LOC81569,LOC96597,LRFN1,MEF2D,MGC13057,MITF,MSRA,MYCN,NAV1,NR1H4,NR3C1,NUDT11,PARVB,PCDHB5,PDK4,PGC,PLAC8,PLD1,PPAP2A,PRKACB,PTPRZ1,RERE,SASH1,SCAMP5,SERTAD4,SESN2,SIRPB1,SIX1,SLC16A9,SLC30A3,SLC30A6,SNCA,SOCS2,ST6GALNAC6,STAR,STAT5A,SYNCOILIN,TGFBR3,TIMM22,TLE4,TLN2,TM9SF1,TRPS1,TSRC1,TYRP1,UBAP1,UGDH,UNC5B,ZBTB4,ZNF135 GENE_SYMBOLS AKR7A2,AOC2,B3GALNT1,C14orf132,TOX2,LYPD3,OSGIN2,CA5A,CACNA2D2,CBS,CCR9,CD28,CHST8,COL4A5,CPN2,CDK12,CX3CR1,DAP,CFD,DHPS,PARM1,FABP7,FHL1,FKRP,CCDC71,CYB5D1,NAT8L,,CHST15,GFI1,GGA1,GNA11,GNPDA1,GPC1,GPR87,GREB1,GTF3C4,YY1AP1,HIC2,HMGXB4,ITPKB,JAM3,HAUS5,FAN1,KRT84,LDB2,LGALS2,PRRT2,ZNF787,SPIN4,SMIM14,LRTOMT,,XPNPEP3,ACTL8,TBC1D27P,LRFN1,MEF2D,C2orf88,MITF,MSRA,MYCN,NAV1,NR1H4,NR3C1,NUDT11,PARVB,PCDHB5,PDK4,PGC,PLAC8,PLD1,PLPP1,PRKACB,PTPRZ1,RERE,SASH1,SCAMP5,SERTAD4,SESN2,SIRPB1,SIX1,SLC16A9,SLC30A3,SLC30A6,SNCA,SOCS2,ST6GALNAC6,STAR,STAT5A,SYNC,TGFBR3,TIMM22,TLE4,TLN2,TM9SF1,TRPS1,ADAMTSL4,TYRP1,UBAP1,UGDH,UNC5B,ZBTB4,ZNF135 FOUNDER_NAMES