STANDARD_NAME GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_DN SYSTEMATIC_NAME M1107 COLLECTION C2:CGP MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_DN NAMESPACE MOUSE_GENE_SYMBOL DESCRIPTION_BRIEF Genes down-regulated in ME-A cells (breast cancer, sensitive to apoptotic stimuli) exposed to doxorubicin [PubChem=31703] in the presence of medium concentrate (MC) from ME-C cells (breast cancer, resistant to apoptotic stimuli). DESCRIPTION_FULL Impairment of the complex regulatory network of cell death and survival is frequently the reason for therapy resistance of breast cancer cells and a major cause of tumor progression. We established two independent cell lines from a fast growing mouse breast tumor (WAP-SVT/t transgenic animal). Cells from one line (ME-A cells) are sensitive to apoptotic stimuli such as growth factor depletion or treatment with antitumor agents (e.g. doxorubicin). Cells from the second line (ME-C cells), which carry a missense mutation at the p53 codon 242, are very insensitive to apoptotic stimuli. Co-cultivation experiments revealed that the ME-C cells mediate cell death resistance to the ME-A cells. Microarray and Western blot analysis showed that osteopontin (OPN) is selectively overexpressed by the ME-C cells. This glycoprotein is the most abundant protein secreted by the ME-C cells and we obtained strong indications that OPN is the main antiapoptotic factor. However, the OPN containing ME-C cell medium does not alter the expression level of pro- or antiapoptotic genes or known inhibitors of apoptosis (IAPs). Its signaling involves mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) kinase (MEK)1/2 as the kinase inhibitor PD98059 restores apoptosis but not the Akt inhibitor. In the ME-A cells, mitochondrial cytochrome c release occurs with and without external apoptotic stimuli. OPN containing ME-C cell medium does not prevent the mitochondrial cytochrome c release and caspase-9 processing. In serum starved ME-A cells, the OPN containing ME-C cell medium prevents caspase-3 activation. However, in doxorubicin-treated cells, although apoptosis is blocked, it does not inhibit caspase-3. This indicates that the ME-A cells distinguish between the initial apoptotic stimuli and that the cells possess a further uncharacterized control element acting downstream from caspase-3. PMID 17160024 GEOID AUTHORS Graessmann M,Berg B,Fuchs B,Klein A,Graessmann A CONTRIBUTOR Arthur Liberzon CONTRIBUTOR_ORG MSigDB Team EXACT_SOURCE Online supplement ME-ACellsDoxorubicinAndMC.xls FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS 0610007P08Rik,0610007P14Rik,0610009C03Rik,0610025P10Rik,0610037L13Rik,0610038D11Rik,0610041E09Rik,1110001K21Rik,1110002N22Rik,1110004E09Rik,1110005A23Rik,1110007M04Rik,1110008H02Rik,1110008J03Rik,1110019J04Rik,1110034C04Rik,1110035L05Rik,1110054H05Rik,1190005F20Rik,1200009O22Rik,1300006N24Rik,14-3-3,1500003O22Rik,1500019G21Rik,1500031M22Rik,1500041O16Rik,1600012F09Rik,1700022C21Rik,1700030K09Rik,1700037H04Rik,1700054N08Rik,1700095N21Rik,1810009A15Rik,1810009N02Rik,1810009O10Rik,1810020E01Rik,1810030O07Rik,1810032O08Rik,1810034K20Rik,1810037K07Rik,1810044O22Rik,2010012C16Rik,2010012O05Rik,2010204K13Rik,2010305A19Rik,2010315L10Rik,2310004L02Rik,2310030G06Rik,2310047M15Rik,2310061I04Rik,2400010G15Rik,2410003A14Rik,2410015N17Rik,2410017P09Rik,2410118I19Rik,2410129E14Rik,2510005D08Rik,2510006C20Rik,2610002M06Rik,2610312E17Rik,2610318G18Rik,2700038C09Rik,2700089E24Rik,2700094F01Rik,2810026P18Rik,2810421I24Rik,2810430M08Rik,2810433K01Rik,2810441K11Rik,2810453I06Rik,2900006B13Rik,2900009I07Rik,2900034E22Rik,2900092E17Rik,2900097C17Rik,3110001D03Rik,3110048E14Rik,3230401I01Rik,3230402J05Rik,4432406C05Rik,4632409L22Rik,4833420G17Rik,4930418P06Rik,4930444A02Rik,4930521E07Rik,4930553M18Rik,4930563C04Rik,4930584N22Rik,4933411K20Rik,4933424N09Rik,4933425A18Rik,4933425K02Rik,5033428A16Rik,5730421E18Rik,5730449L18Rik,5730466H23Rik,5930412E23Rik,6030460N08Rik,6330416G13Rik,6330577E15Rik,6330581L23Rik,6430706D22Rik,6530403A03Rik,8430437G11Rik,9330177P20Rik,9430010O03Rik,9430077D24Rik,9430098E02Rik,A230072I16Rik,A730042J05Rik,A930040G15Rik,AA408296,AA792894,AA881470,Aatf,Abcb7,Abcc1,Abce1,Acbd6,Ache,Acin1,Actb,Acvr1b,Adam17,Adat1,Adck1,AI325464,AI506816,AI851464,Akap12,Akap8,Alg3,Anapc4,Ankrd28,Ap1g1,Ap3m2,Apbb1,Apex1,Arf6,Arhgap5,Arhgef10,Arid4b,Arl6ip5,Armcx1,Arpc1b,Ate1,Atf4,Atf6,Atp5c1,Atxn7l3,AU020206,B130016L12Rik,B230308N11Rik,B230354K17Rik,B930007L02Rik,BC002216,BC003324,BC003965,BC005662,BC017158,BC019943,BC021367,BC021438,BC023181,BC024814,BC025076,BC026432,BC027663,BC027828,BC048403,Bccip,Bcl2l2,Bcl3,Bcl7b,Bcl9,Bclaf1,Bcs1l,Bet1,Bhc80,Bit1,Bnip1,Bnip3l,Bpnt1,Brd8,Bsf3,Btbd3,Btn1a1,Bysl,C1d,C1qbp,C230081A13Rik,C330027C09Rik,C330027I04Rik,C730036B14Rik,C79248,C80913,Casc3,Cat,Cbx1,Cbx3,Ccdc9,Ccl20,Ccl5,Cd200,Cd2ap,Cd44,Cdc6,Cdc91l1,Cdca7,Cdk2,Cdk5rap1,Cdkal1,Cebpb,Cebpg,Ces1,Cetn3,Cgnl1,Chd1l,Chd4,Chx10,Cnn3,Cnot2,Cnot6,Cnot7,Coil,Commd2,Cops7a,Coq3,Cova1,Cox17,Cpne1,Cpt1b,Cri1,Csnk1d,Csnk2a1,Cstf2,Cstf3,Cttn,Cxcl5,Cyp1b1,Cyp2c55,Cyp4f13,D030034H08,D11Ertd18e,D11Ertd707e,D11Lgp1e,D130054N24Rik,D19Bwg1357e,D3Ertd300e,D3Jfr1,D5Bwg0860e,D5Ertd33e,D630048P19Rik,Dars,Dazap1,Dbn1,Dcps,Dctn4,Ddx10,Ddx19b,Deadc1,Depdc6,Dgcr2,Dgcr8,Dhcr24,Dhdds,Dhodh,Dhps,Dhx36,Dhx9,Dnajb12,Dnajc14,Dnm1l,Dnmt2,Dpagt1,Dscr2,Dscr5,Dsg2,Dtl,Dtnbp1,Dtx3,Dtymk,Dusp11,Dusp12,E130103I17Rik,E430003D02Rik,E430007M08Rik,E430018M08Rik,E430036I04Rik,Eef1e1,Ehd2,Eif2s2,Eif4a1,Eif4a2,Eif4b,Eif4e2,Ela1,Elac1,Elac2,Elk1,Enc1,Ensa,Epb4.1l2,Epn2,Eps8l3,Erbb2,Ercc4,ERK1,Es2el,Etf1,Exosc1,Exosc10,Exosc2,Exosc5,Exosc7,F2rl1,F830020C16Rik,Faah,Faim,Farslb,Fbxw11,Fbxw2,Fert2,Fignl1,Fjx1,Fkbp11,Flot1,Fndc4,Fosl2,Foxj3,Foxm1,Foxp1,Frmd4b,Fstl1,Fto,Fubp1,Fusip1,Fxn,G630024C07Rik,Galk1,Gart,Gas5,Gcn5l2,Gcnt1,Gcsh,Gdi1,Gdpd1,Gemin6,Gfpt1,Glycam1,Gm132,Gmfb,Gmnn,Gna-rs1,Gna12,Gnpnat1,Golph3,Gorasp2,Got1,Gpam,Gpiap1,Gpr35,Grtp1,Gsr,Gtf2ird1,Gtpbp2,Gys1,Gys3,Hcfc1,Hdac7a,Hells,Herc4,Hibch,Hip1,Hivep3,Hkr2,Hmbs,Hmga2,Hmgb2l1,Hnrpa1,Hnrpdl,Hnrpl,homer3,Hps1,Hrbl,Hrmt1l1,Hrpt2,Hspa4,Hspa8,Hspa9a,Iars,Ibtk,Ick,Ict1,Ier3,Ifrd2,Ihpk1,Ikbkb,Il13ra1,Il15ra,Il1r1,Il6st,Ilf3,Immt,Ipo8,Ipp,Irf3,Itga5,Ivns1abp,Jtb,Keap1,Khdrbs1,KIAA0179,Kitl,Klf6,Klhl20,Klhl5,Klhl7,Kpna3,Kpnb1,Lancl2,Lbr,Ldlr,Lig3,Lmbr1,Lmnb2,LOC216964,LOC277692,Loxl4,Ltap,Luc7l2,Luzp5,Lyplal1,Mad2l2,Map2k7,Map3k4,Map4k5,Mapk3,Mbd2,Mbd3,Mccc2,Mcm2,Mdfi,Mdn1,Mdp1,Me2,Mettl1,Mga,MGC78289,MGI:1929091,Minpp1,Mitc1,Miz1,Mllt10,Mlp,Morf4l2,Mospd2,Mphosph10,Mrpl12,Mrpl19,Mrpl3,Mrpl32,Mrpl50,Mrps5,Mrrf,Msh3,Msn,Mt1,Mtap,Mtap2,Mtbp,Mtf2,Mthfd2,Mthfs,Mtmr2,Mulk,Muted,Mutyh,Mybbp1a,Myc,Myg1,Mynn,Narg1,Nasp,Nck2,Nf2,Nfib,Nfic,Nfyc,Nicn1,Nipsnap3a,Nisch,Nkd2,Nol5,Nol5a,Nola3,Nolc1,Notch2,Notch4,Nqo3a2,Nr1d2,Nr2c1,Nras,Nsfl1c,Nsmce1,Nt5e,Nubp1,Nudcd1,Numb,Nup133,Nupl1,Nutf2,Nxt1,Ogt,Ophn1,Orc3l,Osbpl9,Osmr,P2rx4,Pabpn1,Paics,Pak3,Papola,Pard6b,Parp2,Pbk,Pbx2,Pcdhb21,Pcnxl3,Pctk1,Pdgfra,Pdha1,Pet112l,Pex11a,Pex14,Phf12,Phip,Phka1,Pigo,Pik3c3,Pipox,Pld2,Plekhc1,Plekhf1,Plk4,Plp2,Plscr1,Pmf1,Pmpcb,Pnn,Pofut1,Polb,Pold1,Pold2,Pold3,Pole,Poli,Polr2i,Polr3a,Polr3f,Pot1,Pou2f1,Ppat,Ppih,Ppil4,Ppp1cc,Ppp2r1b,Ppp2r3a,Pqbp1,Prkcn,Prpf31,Prpf39,Psenen,Psip1,Psmd11,Ptdss2,Ptk9,Ptpn21,Ptprf,Ptprs,Pus3,Pvrl2,Pycs,Rab3d,Rab4a,Rab4b,Rab6ip2,Rabggtb,Rabif,Rad23a,Rad23b,Rad51c,Rai14,Rassf1,Rbbp9,Rbl1,Rbm10,Rbm18,Rce1,Rcl1,Recc1,Rfk,Rfxank,Rgs19,Rhou,Ripk1,Rnaseh1,Rnf110,Rnf12,Rnpc2,Rnu22,Rod1,Ror1,Rp2h,Rpl3,Rpl30,Rpl41,Rpo1-2,Rpo1-4,Rpp14,Rpp21,Rpp40,Rrm1,Rsc1a1,Runx1,Runx2,Rusc2,Ryk,Sc5d,Scamp4,Scya5,Sec14l1,Sec15l1,Sec24d,Seh1l,Sema6d,Senp1,Serpinb1,Sfrs1,Sfrs12,Sfrs2,Sfrs6,Sfrs7,Sfxn1,Sgtb,Sh3md2,Shkbp1,Sin3a,Sip1,Skp2,Slc23a2,Slc25a10,Slc25a13,Slc29a2,Slc35a3,Slc39a11,Slc39a3,Slc4a3,Slc9a8,Smarce1,Smr2,Smyd5,Snapap,Snx5,Socs2,Socs6,Sox6,Sp3,Spag7,Spdef,Spen,Spfh1,Spin,Spna2,Spop,Srcasm,Srprb,Ssbp1,Ssr1,St13,Stam2,Stard4,Stat5a,Stat5b,Statip1,Stk3,Stx8,Suhw3,Suox,Suv39h1,Suv420h1,Syncrip,Taok1,Tars,Tarsl1,Tbc1d17,Tbc1d19,Tbl2,Tbn,Tbrg4,Tcerg1,Tcf7l2,Tcfap4,Tcfcp2l3,Tcfe2a,Tcfl1,Tcof1,Tcp1,Tcra,Tctex1,Tdp1,Tenc1,Tera,Tex27,Tfrc,Thop1,Thrap5,Thsd1,Thsd6,Tia1,Timeless,Timm10,Timm44,Timm8a,Timm9,Timp3,Tk1,Tmem39a,Tmlhe,Tmpo,Tnfaip9,Tomm40,Tpbg,Tpk1,Tpm3,Tprt,Traf2,Traf6,Trib1,Trib3,Trim16,Trip11,Trip13,Trip4,Trub2,Tsga14,Tspan2,Ttc8,Tubb5,Txnip,Txnrd3,Tyms,U2af1l4,Ubap2l,Ube1c,Ube2d3,Ube2g2,Ube2j1,Ube2s,Usp22,Usp34,Usp36,Usp4,Vamp3,Vasp,Vps54,Vrk3,Vti1a,Vti1b,Wac,Wdfy3,Wdr13,Wdr4,Wdr42a,Wdr57,Whsc2,Wisp2,Xpo4,Xpr1,Yeats4,Yes1,Ywhaz,Zbed3,Zbtb12,Zc3hdc7,Zcchc8,Zdhhc3,Zdhhc5,Zdhhc6,zeta,Zfhx1b,Zfp101,Zfp111,Zfp142,Zfp161,Zfp207,Zfp212,Zfp258,Zfp277,Zfp292,Zfp297,Zfp307,Zfp386,Zfp422,Zfp644,Zfp68,Zfp82,Zfp96,Zik1,Znrd1 GENE_SYMBOLS ERCC6L2,ERG28,SNRNP40,NEURL4,CZIB,TRMT112,TMEM167A,NUDT16L1,TEFM,CFAP298,SARNP,NDUFAF4,SNHG6,RITA1,TOMM5,PPP4R3A,C1QTNF12,FOXK2,TRMT1L,TRIL,RAVER1,SFN,RRP8,HSPBP1,DIMT1,NFIC,YAE1,POLR1HASP,C19orf44,ADISSP,CCSAP,STAMBPL1,C11orf98,,CCNQ,TMEM126A,CXorf38,SNHG16,MDP1,MMACHC,CYB5B,MAGOHB,BORCS7,,COA7,USE1,DMAC2,C11orf52,PSMG4,C6orf136,LMF1,NSMCE4A,DCTPP1,PTRHD1,WDR75,TUBB2B,EEF1AKMT1,CHAC2,CHMP1B2P,WDR77,DRAM2,PPDPF,SMIM10L1,TMEM209,SNHG5,FASTKD2,RRP15,SKA1,TMEM216,FAM220A,PHYKPL,PABIR1,FAR1,PAGR1,NORAD,DMAC1,FAM118A,EARS2,FOXN2,TMEM186,ZNF329,C5orf34,RHBDD1,POMK,TCTN3,TAF1D,PELP1,TOE1,CFAP97,ERI2,OXSM,SLC9B1,CNEP1R1,DPH6,TSEN15,ETAA1,INTS7,TRIP11,TMEM268,SFR1,ZNF790,HJURP,SNRNP48,TMEM168,ZMYM6,ARGLU1,WDR82,OCEL1,PTRH2,PCID2,KRBA1,UTP25,KRCC1,BRAT1,D2HGDH,,CEP152,,AATF,ABCB7,ABCC1,ABCE1,ACBD6,ACHE,ACIN1,ACTB,ACVR1B,ADAM17,ADAT1,ADCK1,AKAP12,AKAP8,ALG3,ANAPC4,ANKRD28,AP1G1,AP3M2,APBB1,APEX1,ARF6,ARHGAP5,ARHGEF10,ARID4B,ARL6IP5,ARMCX1,ARPC1B,ATE1,ATF4,ATF6,ATP5F1C,ATXN7L3,HEATR1,,,DCAF1,CPTP,RILPL2,UQCC4,LPCAT1,RUSF1,TTI2,TMEM161A,KRI1,PLEKHG5,METTL22,,ZNF768,CCDC102A,TMEM60,KICS2,BCCIP,BCL2L2,BCL3,BCL7B,BCL9,BCLAF1,BCS1L,BET1,PHF21A,PTRH2,BNIP1,BNIP3L,BPNT1,BRD8,CLCF1,BTBD3,BTN1A1,BYSL,C1D,C1QBP,PEAK1,CIP2A,NT5C3B,FANCM,,URI1,CASC3,CAT,CBX1,CBX3,CCDC9,CCL20,CCL5,CD200,CD2AP,CD44,CDC6,PIGU,CDCA7,CDK2,CDK5RAP1,CDKAL1,CEBPB,CEBPG,,CETN3,CGNL1,CHD1L,CHD4,VSX2,CNN3,CNOT2,CNOT6,CNOT7,COIL,COMMD2,COPS7A,COQ3,ENOX2,COX17,CPNE1,CPT1B,EID1,CSNK1D,CSNK2A1,CSTF2,CSTF3,CTTN,CXCL6,CYP1B1,CYP2C18,CYP4F3,,SLC46A1,CCDC43,GHDC,RNF214,PUM3,SUPT20H,CSDE1,RUFY3,COQ5,OPA3,DARS1,DAZAP1,DBN1,DCPS,DCTN4,DDX10,DDX19B,ADAT2,DEPTOR,DGCR2,DGCR8,DHCR24,DHDDS,DHODH,DHPS,DHX36,DHX9,DNAJB12,DNAJC14,DNM1L,TRDMT1,DPAGT1,PSMG1,PIGP,DSG2,DTL,DTNBP1,DTX3,DTYMK,DUSP11,DUSP12,BBS9,,CBX1,RCCD1,LRRC8C,,EEF1E1,EHD2,EIF2S2,EIF4A1,EIF4A2,EIF4B,EIF4E2,CELA1,ELAC1,ELAC2,ELK1,ENC1,ENSA,EPB41L2,EPN2,EPS8L3,ERBB2,ERCC4,ESS2,ETF1,EXOSC1,EXOSC10,EXOSC2,EXOSC5,EXOSC7,F2RL1,HMBOX1,FAAH,FAIM,FARSB,FBXW11,FBXW2,FER,FIGNL1,FJX1,FKBP11,FLOT1,FNDC4,FOSL2,FOXJ3,FOXM1,FOXP1,FRMD4B,FSTL1,FTO,FUBP1,SRSF10,FXN,ZNF771,GALK1,GART,GAS5,KAT2A,GCNT1,GCSH,GDI1,GDPD1,GEMIN6,GFPT1,GLYCAM1,,GMFB,GMNN,GNL1,GNA12,GNPNAT1,GOLPH3,GORASP2,GOT1,GPAM,CAPRIN1,GPR35,GRTP1,GSR,GTF2IRD1,GTPBP2,GYS1,GYS1,HCFC1,HDAC7,HELLS,HERC4,HIBCH,HIP1,HIVEP3,ZSCAN22,HMBS,HMGA2,HMGXB4,HNRNPA1L2,HNRNPDL,HNRNPL,HPS1,AGFG2,PRMT2,CDC73,HSPA4,HSPA8,HSPA9,IARS1,IBTK,CILK1,MRPL58,IER3,IFRD2,IP6K1,IKBKB,IL13RA1,IL15RA,IL1R1,IL6ST,ILF3,IMMT,IPO8,IPP,IRF3,ITGA5,IVNS1ABP,JTB,,KEAP1,KHDRBS1,KITLG,KLF6,KLHL20,KLHL5,KLHL7,KPNA3,KPNB1,TP53I13,,LANCL2,LBR,LDLR,LIG3,LMBR1,LMNB2,LOXL4,VANGL2,LUC7L2,NCAPG2,LYPLAL1,HEXD,,MAD2L2,MAP2K7,MAP3K4,MAP4K5,MAPK3,MBD2,MBD3,MCCC2,MCM2,MDFI,MDN1,MDP1,ME2,METTL1,MGA,MINPP1,DCP1A,ZBTB17,MLLT10,MARCKSL1,MORF4L2,MOSPD2,MPHOSPH10,MRPL12,MRPL19,MRPL3,MRPL32,MRPL50,MRPS5,MRRF,MSH3,MSN,MT1A,MTAP,MAP2,MTBP,MTF2,MTHFD2,MTHFS,MTMR2,,BLOC1S5,MUTYH,MYBBP1A,MYC,MYG1,MYNN,NAA15,NASP,NCK2,NF2,NFIB,NFIC,NFYC,NICN1,NIPSNAP3A,NISCH,NKD2,NOP58,NOP56,NOP10,NOLC1,NOTCH2,NOTCH4,CYB5R1,NR1D2,NR2C1,NRAS,NSFL1C,NSMCE1,NT5E,NUBP1,NUDCD1,NUMB,NUP133,NUP58,NUTF2,NXT1,OGT,OPHN1,ORC3,OSBPL9,OSMR,P2RX4,PABPN1,PAICS,PAK3,PAPOLA,PARD6B,PARP2,PBK,PBX2,PCDHB18P,PCNX3,CDK16,PDGFRA,PDHA1,GATB,PEX11A,PEX14,PHF12,PHIP,PHKA1,PIGO,PIK3C3,PIPOX,PLD2,FERMT2,PLEKHF1,PLK4,PLP2,PLSCR1,PMF1,PMPCB,PNN,POFUT1,POLB,POLD1,POLD2,POLD3,POLE,POLI,POLR2I,POLR3A,POLR3F,POT1,POU2F1,PPAT,PPIH,PPIL4,PPP1CC,PPP2R1B,PPP2R3A,PQBP1,PRKD3,PRPF31,PRPF39,PSENEN,PSIP1,PSMD11,PTDSS2,TWF1,PTPN21,PTPRF,PTPRS,PUS3,NECTIN2,ALDH18A1,RAB3D,RAB4A,RAB4B,ERC1,RABGGTB,RABIF,RAD23A,RAD23B,RAD51C,RAI14,RASSF1,RBBP9,RBL1,RBM10,RBM18,RCE1,RCL1,RFC1,RFK,RFXANK,RGS19,RHOU,RIPK1,RNASEH1,PCGF2,RLIM,RBM39,SNORD22,PTBP3,ROR1,RP2,RPL3,RPL30,,POLR1B,POLR1A,RPP14,RPP21,RPP40,RRM1,RSC1A1,RUNX1,RUNX2,RUSC2,RYK,SC5D,SCAMP4,CCL5,SEC14L1,EXOC6,SEC24D,SEH1L,SEMA6D,SENP1,,SRSF1,SREK1,SRSF2,SRSF6,SRSF7,SFXN1,SGTB,SH3RF1,SHKBP1,SIN3A,GEMIN2,SKP2,SLC23A2,SLC25A10,SLC25A13,SLC29A2,SLC35A3,SLC39A11,SLC39A3,SLC4A3,SLC9A8,SMARCE1,SMR3B,SMYD5,SNAPIN,SNX5,SOCS2,SOCS6,SOX6,SP3,SPAG7,SPDEF,SPEN,ERLIN1,SPIN1,SPTAN1,SPOP,TOM1L1,SRPRB,SSBP1,SSR1,ST13,STAM2,STARD4,STAT5A,STAT5B,ELP2,STK3,STX8,ZNF280C,SUOX,SUV39H1,KMT5B,SYNCRIP,TAOK1,TARS1,TARS2,TBC1D17,TBC1D19,TBL2,TAF8,TBRG4,TCERG1,TCF7L2,TFAP4,GRHL2,TCF3,VPS72,TCOF1,TCP1,,DYNLT1,TDP1,TNS2,SINHCAF,ZFAND3,TFRC,THOP1,MED16,THSD1,ADAMTSL5,TIA1,TIMELESS,TIMM10,TIMM44,,TIMM9,TIMP3,TK1,TMEM39A,TMLHE,TMPO,STEAP4,TOMM40,TPBG,TPK1,TPM3,PDSS1,TRAF2,TRAF6,TRIB1,TRIB3,TRIM16,TRIP11,TRIP13,TRIP4,TRUB2,CEP41,TSPAN2,TTC8,TUBB,TXNIP,TXNRD3,TYMS,U2AF1L4,UBAP2L,UBA3,UBE2D3,UBE2G2,UBE2J1,UBE2S,USP22,USP34,USP36,USP4,VAMP3,VASP,VPS54,VRK3,VTI1A,VTI1B,WAC,WDFY3,WDR13,WDR4,DCAF8,SNRNP40,NELFA,CCN5,XPO4,XPR1,YEATS4,YES1,YWHAZ,ZBED3,ZBTB12,,ZCCHC8,ZDHHC3,ZDHHC5,ZDHHC6,ZEB2,ZNF124,ZNF226,ZNF142,ZBTB14,ZNF207,ZNF212,ZMYM6,ZNF277,ZNF292,ZBTB22,ZKSCAN4,ZNF519,ZNF22,ZNF644,,ZFP82,ZSCAN12,ZIK1,POLR1H,, FOUNDER_NAMES