STANDARD_NAME GRANDVAUX_IRF3_TARGETS_DN SYSTEMATIC_NAME M11814 COLLECTION C2:CGP MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GRANDVAUX_IRF3_TARGETS_DN NAMESPACE HUMAN_SEQ_ACCESSION DESCRIPTION_BRIEF Genes down-regulated in Jurkat cells (T lymphocyte) by expression of a constitutively active form of IRF3 [GeneID=3661]. DESCRIPTION_FULL Ubiquitously expressed interferon regulatory factor 3 (IRF-3) is directly activated after virus infection and functions as a key activator of the immediate-early alpha/beta interferon (IFN) genes, as well as the RANTES chemokine gene. In the present study, a tetracycline-inducible expression system expressing a constitutively active form of IRF-3 (IRF-3 5D) was combined with DNA microarray analysis to identify target genes regulated by IRF-3. Changes in mRNA expression profiles of 8,556 genes were monitored after Tet-inducible expression of IRF-3 5D. Among the genes upregulated by IRF-3 were transcripts for several known IFN-stimulated genes (ISGs). Subsequent analysis revealed that IRF-3 directly induced the expression of ISG56 in an IFN-independent manner through the IFN-stimulated responsive elements (ISREs) of the ISG56 promoter. These results demonstrate that, in addition to its role in the formation of a functional immediate-early IFN-beta enhanceosome, IRF-3 is able to discriminate among ISRE-containing genes involved in the establishment of the antiviral state as a direct response to virus infection. PMID 11991981 GEOID AUTHORS Grandvaux N,Servant MJ,tenOever B,Sen GC,Balachandran S,Barber GN,Lin R,Hiscott J CONTRIBUTOR Yujin Hoshida CONTRIBUTOR_ORG Broad Institute EXACT_SOURCE Table 2: fold induction < 0 FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS AA203389,AA315872,AI802950,AI920897,AW027713,AW172382,AW297828,D78152,L07590,NM_001797,NM_002890,NM_003105,NM_003816,U18271,U65002,X51420,X59065,Y00636,Z46973 GENE_SYMBOLS PAH,RPS7,MFAP5,TIMP3,CD1B,STK17B,GEM,ANXA4,PPP2R3A,CDH11,RASA1,SORL1,ADAM9,,PLAG1,TYRP1,FGF1,CD58,PIK3C3 FOUNDER_NAMES