STANDARD_NAME	GRANDVAUX_IRF3_TARGETS_UP
SYSTEMATIC_NAME	M5133
COLLECTION	C2:CGP
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GRANDVAUX_IRF3_TARGETS_UP
NAMESPACE	HUMAN_SEQ_ACCESSION
DESCRIPTION_BRIEF	Genes up-regulated in Jurkat cells (T lymphocyte) by expression of a constitutively active form of IRF3 [GeneID=3661].
DESCRIPTION_FULL	Ubiquitously expressed interferon regulatory factor 3 (IRF-3) is directly activated after virus infection and functions as a key activator of the immediate-early alpha/beta interferon (IFN) genes, as well as the RANTES chemokine gene. In the present study, a tetracycline-inducible expression system expressing a constitutively active form of IRF-3 (IRF-3 5D) was combined with DNA microarray analysis to identify target genes regulated by IRF-3. Changes in mRNA expression profiles of 8,556 genes were monitored after Tet-inducible expression of IRF-3 5D. Among the genes upregulated by IRF-3 were transcripts for several known IFN-stimulated genes (ISGs). Subsequent analysis revealed that IRF-3 directly induced the expression of ISG56 in an IFN-independent manner through the IFN-stimulated responsive elements (ISREs) of the ISG56 promoter. These results demonstrate that, in addition to its role in the formation of a functional immediate-early IFN-beta enhanceosome, IRF-3 is able to discriminate among ISRE-containing genes involved in the establishment of the antiviral state as a direct response to virus infection.
PMID	11991981
GEOID	
AUTHORS	Grandvaux N,Servant MJ,tenOever B,Sen GC,Balachandran S,Barber GN,Lin R,Hiscott J
CONTRIBUTOR	Yujin Hoshida
CONTRIBUTOR_ORG	Broad Institute
EXACT_SOURCE	Table 1: fold induction > 0
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	AB004550,AF026939,AF026941,AI739106,D28915,D86724,D90070,M14660,M55542,M64554,M80899,M87284,X03225,X03557,X14034
GENE_SYMBOLS	B4GALT5,IFIT3,,ISG15,IFI44,ARG2,PMAIP1,,GBP1,F13B,AHNAK,OAS2,NR3C1,IFIT1,PLCG2
FOUNDER_NAMES