<?xml version="1.0" encoding="UTF-8" standalone="yes"?>

<!-- Copyright (c) 2004-2026 Broad Institute, Inc., Massachusetts Institute of Technology, and Regents of the University of California.  All rights reserved.
     See license terms at www.gsea-msigdb.org/gsea/license_terms_list. Please note that certain gene sets have special access terms.
-->
<MSIGDB BUILD_DATE="Jan 29, 2026" VERSION="2026.1.Hs" NAME="export">
    <GENESET STANDARD_NAME="GRANDVAUX_IRF3_TARGETS_UP" SYSTEMATIC_NAME="M5133" HISTORICAL_NAMES="" PMID="11991981" AUTHORS="Grandvaux N,Servant MJ,tenOever B,Sen GC,Balachandran S,Barber GN,Lin R,Hiscott J" GEOID="" EXACT_SOURCE="Table 1: fold induction &gt; 0" GENESET_LISTING_URL="" EXTERNAL_DETAILS_URL="" CHIP="HUMAN_SEQ_ACCESSION" CONTRIBUTOR="Yujin Hoshida" CONTRIBUTOR_ORG="Broad Institute" DESCRIPTION_BRIEF="Genes up-regulated in Jurkat cells (T lymphocyte) by expression of a constitutively active form of IRF3 [GeneID=3661]." DESCRIPTION_FULL="Ubiquitously expressed interferon regulatory factor 3 (IRF-3) is directly activated after virus infection and functions as a key activator of the immediate-early alpha/beta interferon (IFN) genes, as well as the RANTES chemokine gene. In the present study, a tetracycline-inducible expression system expressing a constitutively active form of IRF-3 (IRF-3 5D) was combined with DNA microarray analysis to identify target genes regulated by IRF-3. Changes in mRNA expression profiles of 8,556 genes were monitored after Tet-inducible expression of IRF-3 5D. Among the genes upregulated by IRF-3 were transcripts for several known IFN-stimulated genes (ISGs). Subsequent analysis revealed that IRF-3 directly induced the expression of ISG56 in an IFN-independent manner through the IFN-stimulated responsive elements (ISREs) of the ISG56 promoter. These results demonstrate that, in addition to its role in the formation of a functional immediate-early IFN-beta enhanceosome, IRF-3 is able to discriminate among ISRE-containing genes involved in the establishment of the antiviral state as a direct response to virus infection." TAGS="" MEMBERS="AB004550,AF026939,AF026941,AI739106,D28915,D86724,D90070,M14660,M55542,M64554,M80899,M87284,X03225,X03557,X14034" MEMBERS_SYMBOLIZED="AHNAK,ARG2,B4GALT5,F13B,GBP1,IFI44,IFIT1,IFIT3,ISG15,NR3C1,OAS2,PLCG2,PMAIP1" MEMBERS_EZID="10561,2165,2633,2908,3434,3437,384,4939,5336,5366,79026,9334,9636" MEMBERS_MAPPING="AB004550,B4GALT5,9334|AF026939,IFIT3,3437|AF026941,null,null|AI739106,ISG15,9636|D28915,IFI44,10561|D86724,ARG2,384|D90070,PMAIP1,5366|M14660,null,null|M55542,GBP1,2633|M64554,F13B,2165|M80899,AHNAK,79026|M87284,OAS2,4939|X03225,NR3C1,2908|X03557,IFIT1,3434|X14034,PLCG2,5336" FILTERED_BY_SIMILARITY="" FOUNDER_NAMES="" REFINEMENT_DATASETS="" VALIDATION_DATASETS="" CATEGORY_CODE="C2" ORGANISM="Homo sapiens" SUB_CATEGORY_CODE="CGP"/>
</MSIGDB>
