STANDARD_NAME GRASEMANN_RETINOBLASTOMA_WITH_6P_AMPLIFICATION SYSTEMATIC_NAME M14308 COLLECTION C2:CGP MSIGDB_URL https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GRASEMANN_RETINOBLASTOMA_WITH_6P_AMPLIFICATION NAMESPACE HUMAN_GENE_SYMBOL DESCRIPTION_BRIEF Genes changed in retinoblastoma tumors with respect to chromosome 6p amplifications. DESCRIPTION_FULL The paediatric eye tumour retinoblastoma is initiated by inactivation of RB1, a tumour suppressor on chromosome 13q. In addition to RB1 loss, many retinoblastomas show other genetic alterations including gains on chromosomes 6p21-pter and 1q31-q32. Recently, the minimal region of gains on chromosome 6 was narrowed to band p22. We examined genomic gains and expression changes in primary retinoblastomas to identify potential target genes in 6p22. Quantitative multiplex PCR detected copy numbers > or = 3 in 25 (33%) tumours and no gains in 31 of 76 (40%) tumours. The remaining 20 (26%) samples showed gains only at some loci, most often including E2F3 and DEK in 6p22.3. Analysis of RNA from 21 primary retinoblastomas showed that expression levels of these and some other genes in 6p22 correspond to DNA gains. However, KIF 13A, a reported candidate oncogene on 6p, was expressed at low levels or absent. Clinical manifestation of tumours with gains at all 6p22 loci was distinct in that distribution of age at diagnosis was markedly shifted to older age compared to tumours with no or partial gains. In summary, our results suggest that DEK and E2F3 are potential targets of 6p gains in retinoblastoma. PMID 16007192 GEOID AUTHORS Grasemann C,Gratias S,Stephan H,Schüler A,Schramm A,Klein-Hitpass L,Rieder H,Schneider S,Kappes F,Eggert A,Lohmann DR CONTRIBUTOR Leona Saunders CONTRIBUTOR_ORG MSigDB Team EXACT_SOURCE Table 3 FILTERED_BY_SIMILARITY EXTERNAL_NAMES_FOR_SIMILAR_TERMS EXTERNAL_DETAILS_URL SOURCE_MEMBERS ABCF1,CACNA1A,CSNK2B,DEK,E2F3,ELOVL5,HSP90,LSM2,NUP153,PRR3,RAN,RPA40,RPS10,TTRAP,TXNDC GENE_SYMBOLS ABCF1,CACNA1A,CSNK2B,DEK,E2F3,ELOVL5,,LSM2,NUP153,PRR3,RAN,POLR1C,RPS10,TDP2,TMX1 FOUNDER_NAMES