STANDARD_NAME	GROSS_HYPOXIA_VIA_ELK3_UP
SYSTEMATIC_NAME	M1303
COLLECTION	C2:CGP
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GROSS_HYPOXIA_VIA_ELK3_UP
NAMESPACE	MOUSE_SEQ_ACCESSION
DESCRIPTION_BRIEF	Genes up-regulated in SEND cells (skin endothelium) at hypoxia with ELK3 [GeneID=2004] knockdown by RNAi.
DESCRIPTION_FULL	The ternary complex factor Net/Elk3 is downregulated in hypoxia and participates in the induction by hypoxia of several genes, including c-fos, vascular endothelial growth factor and egr-1. However, the global role of Net in hypoxia remains to be elucidated. We have identified, in a large-scale analysis of RNA expression using microarrays, more than 370 genes that are regulated by Net in hypoxia. In order to gain insights into the role of Net in hypoxia, we have analysed in parallel the genes regulated by HIF-1alpha, the classical factor involved in the response to hypoxia. We identified about 190 genes that are regulated by HIF-1alpha in hypoxia. Surprisingly, when we compare the genes induced by hypoxia that require either Net or HIF-1alpha, the majority are the same (75%), suggesting that the functions of both factors are closely linked. Interestingly, in hypoxia, Net regulates the expression of several genes known to control HIF-1alpha stability, including PHD2, PHD3 and Siah2, suggesting that Net regulates the stability of HIF-1alpha. We found that inhibition of Net by RNAi leads to decreased HIF-1alpha expression at the protein level in hypoxia. These results indicate that Net participates in the transcriptional response to hypoxia by regulation of HIF-1alpha protein stability.
PMID	17704799
GEOID	
AUTHORS	Gross C,Dubois-Pot H,Wasylyk B
CONTRIBUTOR	Jessica Robertson
CONTRIBUTOR_ORG	MSigDB Team
EXACT_SOURCE	Table 2S: Fold Change > 0
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	AF089721,AF133669,AJ246002,AK002951,AK004278,AK004440,AK008870,AK009316,AK011193,AK012957,AK014218,AK016033,AK020032,AK021390,AK050989,BC005803,BC008522,BC013720,BC016221,BC016575,BC023820,BC025531,BC029086,BC031769,BC037471,BC039639,BC051539,NM_007444,NM_007528,NM_007554,NM_007630,NM_007631,NM_007658,NM_007671,NM_007681,NM_007778,NM_007830,NM_007915,NM_007932,NM_007955,NM_007987,NM_007988,NM_008090,NM_008139,NM_008160,NM_008209,NM_008235,NM_008258,NM_008284,NM_008338,NM_008538,NM_008659,NM_008714,NM_008786,NM_008856,NM_008885,NM_008893,NM_008924,NM_008928,NM_009004,NM_009104,NM_009128,NM_009159,NM_009178,NM_009194,NM_009277,NM_009448,NM_009465,NM_009469,NM_009517,NM_009542,NM_009547,NM_009593,NM_009665,NM_009676,NM_009689,NM_009810,NM_009828,NM_009932,NM_009949,NM_009964,NM_010169,NM_010178,NM_010256,NM_010301,NM_010436,NM_010460,NM_010590,NM_010655,NM_010799,NM_010811,NM_010872,NM_010890,NM_011014,NM_011050,NM_011150,NM_011284,NM_011356,NM_011358,NM_011594,NM_011638,NM_011654,NM_011779,NM_011951,NM_012012,NM_012025,NM_012030,NM_012032,NM_013495,NM_013555,NM_013630,NM_013655,NM_013750,NM_013753,NM_013812,NM_013912,NM_015781,NM_016748,NM_016757,NM_016809,NM_016860,NM_016900,NM_017407,NM_019410,NM_019444,NM_019641,NM_019693,NM_019764,NM_019774,NM_020606,NM_021330,NM_021462,NM_021497,NM_021515,NM_021528,NM_021548,NM_021897,NM_022012,NM_022309,NM_023055,NM_023136,NM_023209,NM_023294,NM_023317,NM_023336,NM_023418,NM_023431,NM_023543,NM_023719,NM_024223,NM_025437,NM_025846,NM_025980,NM_026410,NM_026554,NM_026756,NM_026785,NM_026918,NM_028763,NM_028783,NM_028812,NM_029850,NM_030143,NM_030210,NM_031843,NM_053078,NM_053207,NM_053246,NM_054087,NM_080562,NM_130450,NM_133249,NM_133655,NM_133678,NM_133705,NM_133838,NM_133983,NM_138672,NM_144509,NM_144850,NM_145376,NM_145569,NM_145611,NM_145926,NM_146035,NM_146083,NM_146116,NM_146135,NM_146171,NM_153319,NM_153412,NM_153459,NM_172301,NM_172395,NM_172691,NM_172696,NM_173371,NM_173374,NM_173402,NM_175400,NM_176833,NM_176979,NM_177305,NM_177561,NM_177687,NM_177688,NM_178347,NM_178939,NM_181416,NM_181452,NM_198438,NM_201389,U37501
GENE_SYMBOLS	SMO,ARL6IP1,SPAST,STXBP5,FNBP1,TARDBP,INIP,SKI,PLXNA1,IGDCC3,TNRC6A,HOXD8,SF3A1,HELLS,EFNA5,RCC2,SETD7,PPRC1,,ARRB1,KDSR,,NSL1,GET1,TNS1,RXRA,SSH1,AMD1,BCL6B,BMP4,CCNB2,CCND1,CDC25A,CDKN2C,CENPA,CSF1,DBI,EI24,ENG,PTPRVP,FAS,FASN,GATA2,GNAQ,GPX1,MR1,HES1,JPT1,HRAS,IFNGR2,MARCKS,MYO1C,NOTCH1,PCMT1,PRKCH,PMP22,POLA2,PRKAR2A,MAP2K3,KIF20A,RRM2,SCD,SRSF5,ST3GAL4,SLC12A2,TRIM21,TUBA1C,AXL,ULK1,ZMAT3,,ZBTB14,ABCG1,AMD1,AOX1,BIRC5,CASP3,CCNA2,COL4A2,CPT2,CRYAB,F2R,SRSF10,GART,GNA11,H2AX,HOXB7,AJUBA,KPNA2,MINPP1,NDST2,NAIP,NEDD4,SIGMAR1,PDCD4,LGALS3BP,RPA2,FRZB,SRSF2,TIMP2,TFRC,TUBA1B,CORO1C,MAPK14,EXO1,RACGAP1,NHERF1,SERINC3,CPT1A,HOXD9,PKD1,CXCL12,PHLDA3,PALD1,CDK2AP1,APLN,NAP1L1,CTPS1,WBP1,RBM3,ACTR1A,CAV2,SPAG5,PFN2,RAMP2,STMN1,DDX39B,AMOTL2,AKAP8,PARVA,ACP1,MKNK2,NECTIN3,AK1,CHST12,ARPP19,TP53INP1,MAP3K11,CBFB,NHERF2,DTYMK,PBK,NDC80,NDE1,BRD3,PGAM1,PWWP3A,CHN2,TXNIP,CRIP2,EIF1AX,RRAS2,NRARP,CDCA5,NCBP2,NFIC,UBE2C,ZG16,CBX6,ROBO4,GTF2E1,BCL7A,DDIT4L,AACS,DPP7,NREP,EGLN1,DOK4,SLC19A2,UBOX5,ELOVL6,PPARGC1B,CD81,SAC3D1,PYCR2,EHD4,CD276,STAB1,ARL6IP4,RAPGEF3,LPCAT1,MAT2A,KANK2,MGAT4B,MGAT2,SRSF7,TUBB4B,PIAS3,NCAPD2,AMOT,PHLDB2,DUSP7,CCNB1,CDC42SE1,ATOSB,PATJ,H6PD,SRSF1,RGS12,SEPHS1,PPM1F,TOPBP1,ARL4C,USP46,CREBL2,H2AJ,CDC23,PDRG1,ARHGAP11A,FAM89B,SSBP3,PLEC,LAMA5
FOUNDER_NAMES