STANDARD_NAME	GSE10239_MEMORY_VS_DAY4.5_EFF_CD8_TCELL_DN
SYSTEMATIC_NAME	M3074
COLLECTION	C7:IMMUNESIGDB
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE10239_MEMORY_VS_DAY4.5_EFF_CD8_TCELL_DN
NAMESPACE	HUMAN_GENE_SYMBOL
DESCRIPTION_BRIEF	Genes down-regulated in comparison of memory CD8 T cells versus effector CD8 T cells.
DESCRIPTION_FULL	Using killer cell lectin-like receptor G1 as a marker to distinguish terminal effector cells from memory precursors, we found that despite their diverse cell fates both subsets possessed remarkably similar gene expression profiles and functioned as equally potent killer cells. However, only the memory precursors were capable of making IL-2 thus defining a novel effector cell that was cytotoxic, expressed granzyme B, and produced inflammatory cytokines in addition to IL-2. This effector population then differentiated into long-lived protective memory T cells capable of self-renewal and rapid re-call responses. Mechanistic studies showed that cells that continued to receive antigenic stimulation during the later stages of infection were more likely to become terminal effectors. Importantly, curtailing antigenic stimulation towards the tail-end of the acute infection enhanced the generation of memory cells. These studies support the decreasing potential model of memory differentiation and show that the duration of antigenic stimulation is a critical regulator of memory formation
PMID	18316415
GEOID	GSE10239
AUTHORS	Sarkar S,Kalia V,Haining WN,Konieczny BT,Subramaniam S,Ahmed R
CONTRIBUTOR	Jernej Godec
CONTRIBUTOR_ORG	Dana-Farber Cancer Institute
EXACT_SOURCE	GSE10239_1404_200_DN
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	AASDH,ACTL6A,ACTR3,AHCYL2,AIFM1,ALG10,ALKBH5,ANKRD46,AP1S2,AP3S1,ARF6,ARFIP1,ASXL1,ATL2,AURKB,BCL2L11,BUB1B,C11orf31,C13orf27,C1D,C1GALT1,C1orf52,C20orf7,C6orf70,CAND1,CASD1,CBX3,CCDC34,CCDC6,CDC16,CDC20,CDC7,CDCA5,CDK1,CDK17,CLCN3,COPS5,CRK,CSNK2A2,CTPS,CYP20A1,DCUN1D5,DIDO1,DR1,DRAM2,DUSP4,E2F3,EAF1,EED,EIF1AX,EPT1,EWSR1,FAIM,FAM188A,FARP1,FBXW11,FDFT1,FEM1B,FEN1,FLVCR1,FRMD4B,GAPVD1,GARS,GINS1,GINS2,GLRX3,GNA13,GRSF1,GSR,GTF2B,GZMB,HARS,HMGCR,HMGCS1,HSD17B12,IBTK,ICOS,IDH3A,IPO5,ITPR1,KCMF1,KDM1B,KDSR,KIF22,KLHDC2,LAMTOR3,LDHA,LRBA,LUC7L2,MAP3K1,MAPK9,MARCH5,MBTPS2,MCM10,MCM2,MCM4,MCM5,MEMO1,METAP2,MFF,MLEC,MORF4L2,MRPL39,MRPL44,MSL3,NAA20,NAA30,NARS,NFYB,NUDT5,NUP54,OPA1,PAFAH1B2,PAK2,PDLIM5,PEX13,PGK1,PIGL,PLK4,POGZ,POU2AF1,PPM1H,PPP1R7,PRIM1,PRPF38A,PRPS1,PSPC1,PTCH1,PTPLAD1,QRSL1,RAB14,RAD23B,RAPGEF2,RBM7,RFC5,RFX5,RNF219,RPL23,RPP30,RPS2,RRM1,RRS1,RSBN1,RWDD4,SAP30,SAV1,SC5DL,SET,SETD6,SLBP,SLC25A13,SLC25A3,SLC25A4,SLC33A1,SLC35E2B,SLC39A6,SLC7A1,SLMO2,SMARCC1,SNRNP40,SNRPA1,SPCS3,SQLE,SRSF10,SRSF9,SSBP1,SSR3,STRAP,STRN,TAF3,TAF5,TCEANC,TEX10,THOC7,TIAM1,TM9SF2,TNFRSF9,TP53BP1,TRA2B,TRIM59,TSTD2,TUBB2A,TYMS,UBA2,UBP1,UFSP2,USP39,USP42,VAMP3,VAPA,VKORC1L1,VMA21,WSB1,XPO7,YAF2,YIPF5,YTHDF2,ZFP161,ZNF236,ZWILCH
GENE_SYMBOLS	AASDH,ACTL6A,ACTR3,AHCYL2,AIFM1,ALG10,ALKBH5,ANKRD46,AP1S2,AP3S1,ARF6,ARFIP1,ASXL1,ATL2,AURKB,BCL2L11,BUB1B,SELENOH,TEX30,C1D,C1GALT1,C1orf52,NDUFAF5,ERMARD,CAND1,CASD1,CBX3,CCDC34,CCDC6,CDC16,CDC20,CDC7,CDCA5,CDK1,CDK17,CLCN3,COPS5,CRK,CSNK2A2,CTPS1,CYP20A1,DCUN1D5,DIDO1,DR1,DRAM2,DUSP4,E2F3,EAF1,EED,EIF1AX,SELENOI,EWSR1,FAIM,MINDY3,FARP1,FBXW11,FDFT1,FEM1B,FEN1,FLVCR1,FRMD4B,GAPVD1,GARS1,GINS1,GINS2,GLRX3,GNA13,GRSF1,GSR,GTF2B,GZMB,HARS1,HMGCR,HMGCS1,HSD17B12,IBTK,ICOS,IDH3A,IPO5,ITPR1,KCMF1,KDM1B,KDSR,KIF22,KLHDC2,LAMTOR3,LDHA,LRBA,LUC7L2,MAP3K1,MAPK9,MARCHF5,MBTPS2,MCM10,MCM2,MCM4,MCM5,MEMO1,METAP2,MFF,MLEC,MORF4L2,MRPL39,MRPL44,MSL3,NAA20,NAA30,NARS1,NFYB,NUDT5,NUP54,OPA1,PAFAH1B2,PAK2,PDLIM5,PEX13,PGK1,PIGL,PLK4,POGZ,POU2AF1,PPM1H,PPP1R7,PRIM1,PRPF38A,PRPS1,PSPC1,PTCH1,HACD3,QRSL1,RAB14,RAD23B,RAPGEF2,RBM7,RFC5,RFX5,OBI1,RPL23,RPP30,RPS2,RRM1,RRS1,RSBN1,RWDD4,SAP30,SAV1,SC5D,SET,SETD6,SLBP,SLC25A13,SLC25A3,SLC25A4,SLC33A1,SLC35E2B,SLC39A6,SLC7A1,PRELID3B,SMARCC1,SNRNP40,SNRPA1,SPCS3,SQLE,SRSF10,SRSF9,SSBP1,SSR3,STRAP,STRN,TAF3,TAF5,TCEANC,TEX10,THOC7,TIAM1,TM9SF2,TNFRSF9,TP53BP1,TRA2B,TRIM59,TSTD2,TUBB2A,TYMS,UBA2,UBP1,UFSP2,USP39,USP42,VAMP3,VAPA,VKORC1L1,VMA21,WSB1,XPO7,YAF2,YIPF5,YTHDF2,ZBTB14,ZNF236,ZWILCH
FOUNDER_NAMES