STANDARD_NAME	GSE11884_WT_VS_FURIN_KO_NAIVE_CD4_TCELL_UP
SYSTEMATIC_NAME	M407
COLLECTION	C7:IMMUNESIGDB
MSIGDB_URL	https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE11884_WT_VS_FURIN_KO_NAIVE_CD4_TCELL_UP
NAMESPACE	HUMAN_GENE_SYMBOL
DESCRIPTION_BRIEF	Genes up-regulated in naïve wildtype CD4 [GeneID=920] T cells versus those from T cell specific FURIN [GeneID=5045] knockout mice.
DESCRIPTION_FULL	Furin is a proprotein convertase induced in activated T cells, reported to processes the anti-inflammatory cytokine TGFb-1. Herein, we show that conditional deletion of furin in T cells allowed for normal T cell development but impaired the function of regulatory T cells and effector cells, which produced less TGFb-1. Furin-deficient Treg cells, were less protective in a T cell transfer colitis model and failed to induce Foxp3 in normal T cells. Furin-deficient effector cells were inherently overly active and were resistant to suppressive activity of wild-type Tregs. Thus, our results indicate that furin is indispensable in maintaining peripheral tolerance, which is due, at least in part, to its nonredundant, essential function in regulating TGFb-1 production. Targeting furin has emerged as a strategy in malignant and infectious disease. The current work suggests that inhibiting furin might activate immune responses, but may result in a breakdown in peripheral tolerance.
PMID	18701887
GEOID	GSE11884
AUTHORS	Pesu M,Watford WT,Wei L,Xu L,Fuss I,Strober W,Andersson J,Shevach EM,Quezado M,Bouladoux N,Roebroek A,Belkaid Y,Creemers J,O'Shea JJ
CONTRIBUTOR	Jernej Godec
CONTRIBUTOR_ORG	Dana-Farber Cancer Institute
EXACT_SOURCE	GSE11884_2701_200_UP
FILTERED_BY_SIMILARITY	
EXTERNAL_NAMES_FOR_SIMILAR_TERMS	
EXTERNAL_DETAILS_URL	
SOURCE_MEMBERS	1110004E09Rik,1700001L05Rik,1700003M02Rik,2010002M12Rik,2210411K11Rik,2310039D24Rik,4732471D19Rik,4930428E23Rik,4930579G24Rik,6330409D20Rik,ACAA2,ACOT3,ADAMTS4,AKP3,ALDH5A1,ANK1,ANKRD34B,ANXA1,APOF,ARMCX6,ASPH,AU017455,B230354K17Rik,BAALC,BC029214,BC037703,BMPR1A,C230055K05Rik,CATSPER1,CCDC107,CCDC67,CCL1,CCR8,CCRL2,CD209B,CD8B1,CLCN7,CNN3,COPS5,CRIP2,CRYM,CSNK1G2,CST12,CTGF,CYBRD1,D6ERTD474E,DAPL1,DARC,DAZAP2,DEFB10,DKKL1,DLX1AS,DNAHC6,DOK3,DSCC1,DTHD1,E130309D14Rik,ECH1,EXT1,FAM73B,FCGR4,FEZF2,FGFR1,FHAD1,FLRT1,FXYD7,GALR2,GARNL3,GGTA1,GHRH,GM10291,GM10498,GM10840,GM12466,GM15348,GM16391,GM5447,GM6140,GM7060,GM7634,GM9034,GM9081,GM9282,GM9292,GM9804,GPR153,GRIN2C,GRK4,HEATR3,HILS1,HIP1,HTR5A,IFNA2,IL28RA,IL9,IRF2BP2,KCTD12,KLHL13,LASS4,LIPC,LMOD3,LPAR2,LRRC30,MARCH8,MED10,MEPE,MIR124A-1,MIR144,MIR674,MIR99B,MIRLET7A-1,MOXD1,MRPS31,MTBP,MUM1L1,NCKAP5L,NDUFA10,NFKBID,NLRP4F,NRCAM,NUT,OLFR1098,OLFR110,OLFR1107,OLFR1294,OLFR1412,OLFR835,OLFR891,OMP,OTOG,OXTR,PDGFRB,PDIK1L,PDLIM2,PID1,PILRA,PIR,PLCXD2,PLIN1,PM20D1,POM121L2,PRRG2,PRTN3,PTCD1,PTGDR,PTRF,RAB4B,RABL5,RIMKLA,RNF152,RNF186,RNMTL1,RPL27A-PS2,RPN1,RPS4Y2,RRAD,RUSC2,SEC22B,SELP,SERPINA1D,SERPINB8,SEZ6,SH3PXD2A,SHBG,SLC25A10,SLC31A1,SLC6A3,SLC7A13,SLCO4C1,SMT3H2-PS,SMTNL1,SNRPB,SNX18,SRGAP1,SSTR4,TAGAP,TARBP2,TBC1D9B,TCF7,TDRD12,TEX13,TJP2,TM7SF3,TOMM34,TTC25,TYROBP,UNC45A,VMN1R42,VMN2R-PS33,VMN2R-PS57,VMN2R68,WAS,WDR8,XYLB,ZBTB7C,ZEB2,ZFP105,ZFP319,ZFP579,ZFP90
GENE_SYMBOLS	,,,,,,,,,,ACAA2,,ADAMTS4,,ALDH5A1,ANK1,ANKRD34B,ANXA1,APOF,ARMCX6,ASPH,,,BAALC,PAXX,MAB21L3,BMPR1A,,CATSPER1,CCDC107,DEUP1,CCL1,CCR8,CCRL2,,CD8B,CLCN7,CNN3,COPS5,CRIP2,CRYM,CSNK1G2,,CCN2,CYBRD1,,DAPL1,ACKR1,DAZAP2,,DKKL1,,,DOK3,DSCC1,DTHD1,,ECH1,EXT1,MIGA2,,FEZF2,FGFR1,FHAD1,FLRT1,FXYD7,GALR2,GARNL3,GGTA1,GHRH,,,,,,,,,,,,,,,,GPR153,GRIN2C,GRK4,HEATR3,H1-9P,HIP1,HTR5A,IFNA2,IFNLR1,IL9,IRF2BP2,KCTD12,KLHL13,CERS4,LIPC,LMOD3,LPAR2,LRRC30,MARCHF8,MED10,MEPE,,MIR144,,MIR99B,,MOXD1,MRPS31,MTBP,PWWP3B,NCKAP5L,NDUFA10,NFKBID,,NRCAM,NUTM1,,,,,,,,OMP,OTOG,OXTR,PDGFRB,PDIK1L,PDLIM2,PID1,PILRA,PIR,PLCXD2,PLIN1,PM20D1,POM121L2,PRRG2,PRTN3,PTCD1,PTGDR,CAVIN1,RAB4B,IFT22,RIMKLA,RNF152,RNF186,MRM3,,RPN1,RPS4Y2,RRAD,RUSC2,SEC22B,SELP,,SERPINB8,SEZ6,SH3PXD2A,SHBG,SLC25A10,SLC31A1,SLC6A3,SLC7A13,SLCO4C1,,SMTNL1,SNRPB,SNX18,SRGAP1,SSTR4,TAGAP,TARBP2,TBC1D9B,TCF7,TDRD12,,TJP2,TM7SF3,TOMM34,ODAD4,TYROBP,UNC45A,,,,,WAS,WRAP73,XYLB,ZBTB7C,ZEB2,,,,ZFP90
FOUNDER_NAMES