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     See license terms at www.gsea-msigdb.org/gsea/license_terms_list. Please note that certain gene sets have special access terms.
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<MSIGDB BUILD_DATE="Jan 29, 2026" VERSION="2026.1.Hs" NAME="export">
    <GENESET STANDARD_NAME="GSE11884_WT_VS_FURIN_KO_NAIVE_CD4_TCELL_UP" SYSTEMATIC_NAME="M407" HISTORICAL_NAMES="" PMID="18701887" AUTHORS="Pesu M,Watford WT,Wei L,Xu L,Fuss I,Strober W,Andersson J,Shevach EM,Quezado M,Bouladoux N,Roebroek A,Belkaid Y,Creemers J,O'Shea JJ" GEOID="GSE11884" EXACT_SOURCE="GSE11884_2701_200_UP" GENESET_LISTING_URL="" EXTERNAL_DETAILS_URL="" CHIP="HUMAN_GENE_SYMBOL" CONTRIBUTOR="Jernej Godec" CONTRIBUTOR_ORG="Dana-Farber Cancer Institute" DESCRIPTION_BRIEF="Genes up-regulated in naïve wildtype CD4 [GeneID=920] T cells versus those from T cell specific FURIN [GeneID=5045] knockout mice." DESCRIPTION_FULL="Furin is a proprotein convertase induced in activated T cells, reported to processes the anti-inflammatory cytokine TGFb-1. Herein, we show that conditional deletion of furin in T cells allowed for normal T cell development but impaired the function of regulatory T cells and effector cells, which produced less TGFb-1. Furin-deficient Treg cells, were less protective in a T cell transfer colitis model and failed to induce Foxp3 in normal T cells. Furin-deficient effector cells were inherently overly active and were resistant to suppressive activity of wild-type Tregs. Thus, our results indicate that furin is indispensable in maintaining peripheral tolerance, which is due, at least in part, to its nonredundant, essential function in regulating TGFb-1 production. Targeting furin has emerged as a strategy in malignant and infectious disease. The current work suggests that inhibiting furin might activate immune responses, but may result in a breakdown in peripheral tolerance." TAGS="" MEMBERS="1110004E09Rik,1700001L05Rik,1700003M02Rik,2010002M12Rik,2210411K11Rik,2310039D24Rik,4732471D19Rik,4930428E23Rik,4930579G24Rik,6330409D20Rik,ACAA2,ACOT3,ADAMTS4,AKP3,ALDH5A1,ANK1,ANKRD34B,ANXA1,APOF,ARMCX6,ASPH,AU017455,B230354K17Rik,BAALC,BC029214,BC037703,BMPR1A,C230055K05Rik,CATSPER1,CCDC107,CCDC67,CCL1,CCR8,CCRL2,CD209B,CD8B1,CLCN7,CNN3,COPS5,CRIP2,CRYM,CSNK1G2,CST12,CTGF,CYBRD1,D6ERTD474E,DAPL1,DARC,DAZAP2,DEFB10,DKKL1,DLX1AS,DNAHC6,DOK3,DSCC1,DTHD1,E130309D14Rik,ECH1,EXT1,FAM73B,FCGR4,FEZF2,FGFR1,FHAD1,FLRT1,FXYD7,GALR2,GARNL3,GGTA1,GHRH,GM10291,GM10498,GM10840,GM12466,GM15348,GM16391,GM5447,GM6140,GM7060,GM7634,GM9034,GM9081,GM9282,GM9292,GM9804,GPR153,GRIN2C,GRK4,HEATR3,HILS1,HIP1,HTR5A,IFNA2,IL28RA,IL9,IRF2BP2,KCTD12,KLHL13,LASS4,LIPC,LMOD3,LPAR2,LRRC30,MARCH8,MED10,MEPE,MIR124A-1,MIR144,MIR674,MIR99B,MIRLET7A-1,MOXD1,MRPS31,MTBP,MUM1L1,NCKAP5L,NDUFA10,NFKBID,NLRP4F,NRCAM,NUT,OLFR1098,OLFR110,OLFR1107,OLFR1294,OLFR1412,OLFR835,OLFR891,OMP,OTOG,OXTR,PDGFRB,PDIK1L,PDLIM2,PID1,PILRA,PIR,PLCXD2,PLIN1,PM20D1,POM121L2,PRRG2,PRTN3,PTCD1,PTGDR,PTRF,RAB4B,RABL5,RIMKLA,RNF152,RNF186,RNMTL1,RPL27A-PS2,RPN1,RPS4Y2,RRAD,RUSC2,SEC22B,SELP,SERPINA1D,SERPINB8,SEZ6,SH3PXD2A,SHBG,SLC25A10,SLC31A1,SLC6A3,SLC7A13,SLCO4C1,SMT3H2-PS,SMTNL1,SNRPB,SNX18,SRGAP1,SSTR4,TAGAP,TARBP2,TBC1D9B,TCF7,TDRD12,TEX13,TJP2,TM7SF3,TOMM34,TTC25,TYROBP,UNC45A,VMN1R42,VMN2R-PS33,VMN2R-PS57,VMN2R68,WAS,WDR8,XYLB,ZBTB7C,ZEB2,ZFP105,ZFP319,ZFP579,ZFP90" MEMBERS_SYMBOLIZED="ACAA2,ACKR1,ADAMTS4,ALDH5A1,ANK1,ANKRD34B,ANXA1,APOF,ARMCX6,ASPH,BAALC,BMPR1A,CATSPER1,CAVIN1,CCDC107,CCL1,CCN2,CCR8,CCRL2,CD8B,CERS4,CLCN7,CNN3,COPS5,CRIP2,CRYM,CSNK1G2,CYBRD1,DAPL1,DAZAP2,DEUP1,DKKL1,DOK3,DSCC1,DTHD1,ECH1,EXT1,FEZF2,FGFR1,FHAD1,FLRT1,FXYD7,GALR2,GARNL3,GGTA1,GHRH,GPR153,GRIN2C,GRK4,H1-9P,HEATR3,HIP1,HTR5A,IFNA2,IFNLR1,IFT22,IL9,IRF2BP2,KCTD12,KLHL13,LIPC,LMOD3,LPAR2,LRRC30,MAB21L3,MARCHF8,MED10,MEPE,MIGA2,MIR144,MIR99B,MOXD1,MRM3,MRPS31,MTBP,NCKAP5L,NDUFA10,NFKBID,NRCAM,NUTM1,ODAD4,OMP,OTOG,OXTR,PAXX,PDGFRB,PDIK1L,PDLIM2,PID1,PILRA,PIR,PLCXD2,PLIN1,PM20D1,POM121L2,PRRG2,PRTN3,PTCD1,PTGDR,PWWP3B,RAB4B,RIMKLA,RNF152,RNF186,RPN1,RPS4Y2,RRAD,RUSC2,SEC22B,SELP,SERPINB8,SEZ6,SH3PXD2A,SHBG,SLC25A10,SLC31A1,SLC6A3,SLC7A13,SLCO4C1,SMTNL1,SNRPB,SNX18,SRGAP1,SSTR4,TAGAP,TARBP2,TBC1D9B,TCF7,TDRD12,TJP2,TM7SF3,TOMM34,TYROBP,UNC45A,WAS,WRAP73,XYLB,ZBTB7C,ZEB2,ZFP90" MEMBERS_EZID="10240,10449,10953,10987,112574,114827,115207,117144,117289,1186,1237,124925,1266,126868,1317,139221,1397,140032,1428,1455,146198,1468,148811,1490,149420,157724,159989,163702,1891,201501,203260,2131,219537,220441,220972,2260,23061,23769,2532,256646,257068,26002,26024,2681,2691,27085,27120,284119,284716,286,286257,2868,2905,29992,301,3092,319,3361,339291,340120,340990,3440,353189,3578,359948,373861,387509,3990,401124,406936,407056,444,4705,4897,4975,49856,5021,5159,51768,5271,5346,53822,53916,54470,54546,55022,55027,55079,55178,55898,56203,5639,5657,56955,5729,57522,57701,6184,6236,6346,6403,64236,6462,64792,6531,657,6628,6754,6895,6932,7305,7454,79075,7915,79603,79870,79901,79930,83538,84246,84253,84807,84895,8544,8811,90293,9034,91646,9170,92196,926,94026,9414,9507,9554,9644,9802,9839,9853,9942" MEMBERS_MAPPING="1110004E09Rik,null,null|1700001L05Rik,null,null|1700003M02Rik,null,null|2010002M12Rik,null,null|2210411K11Rik,null,null|2310039D24Rik,null,null|4732471D19Rik,null,null|4930428E23Rik,null,null|4930579G24Rik,null,null|6330409D20Rik,null,null|ACAA2,ACAA2,10449|ACOT3,null,null|ADAMTS4,ADAMTS4,9507|AKP3,null,null|ALDH5A1,ALDH5A1,7915|ANK1,ANK1,286|ANKRD34B,ANKRD34B,340120|ANXA1,ANXA1,301|APOF,APOF,319|ARMCX6,ARMCX6,54470|ASPH,ASPH,444|AU017455,null,null|B230354K17Rik,null,null|BAALC,BAALC,79870|BC029214,PAXX,286257|BC037703,MAB21L3,126868|BMPR1A,BMPR1A,657|C230055K05Rik,null,null|CATSPER1,CATSPER1,117144|CCDC107,CCDC107,203260|CCDC67,DEUP1,159989|CCL1,CCL1,6346|CCR8,CCR8,1237|CCRL2,CCRL2,9034|CD209B,null,null|CD8B1,CD8B,926|CLCN7,CLCN7,1186|CNN3,CNN3,1266|COPS5,COPS5,10987|CRIP2,CRIP2,1397|CRYM,CRYM,1428|CSNK1G2,CSNK1G2,1455|CST12,null,null|CTGF,CCN2,1490|CYBRD1,CYBRD1,79901|D6ERTD474E,null,null|DAPL1,DAPL1,92196|DARC,ACKR1,2532|DAZAP2,DAZAP2,9802|DEFB10,null,null|DKKL1,DKKL1,27120|DLX1AS,null,null|DNAHC6,null,null|DOK3,DOK3,79930|DSCC1,DSCC1,79075|DTHD1,DTHD1,401124|E130309D14Rik,null,null|ECH1,ECH1,1891|EXT1,EXT1,2131|FAM73B,MIGA2,84895|FCGR4,null,null|FEZF2,FEZF2,55079|FGFR1,FGFR1,2260|FHAD1,FHAD1,114827|FLRT1,FLRT1,23769|FXYD7,FXYD7,53822|GALR2,GALR2,8811|GARNL3,GARNL3,84253|GGTA1,GGTA1,2681|GHRH,GHRH,2691|GM10291,null,null|GM10498,null,null|GM10840,null,null|GM12466,null,null|GM15348,null,null|GM16391,null,null|GM5447,null,null|GM6140,null,null|GM7060,null,null|GM7634,null,null|GM9034,null,null|GM9081,null,null|GM9282,null,null|GM9292,null,null|GM9804,null,null|GPR153,GPR153,387509|GRIN2C,GRIN2C,2905|GRK4,GRK4,2868|HEATR3,HEATR3,55027|HILS1,H1-9P,373861|HIP1,HIP1,3092|HTR5A,HTR5A,3361|IFNA2,IFNA2,3440|IL28RA,IFNLR1,163702|IL9,IL9,3578|IRF2BP2,IRF2BP2,359948|KCTD12,KCTD12,115207|KLHL13,KLHL13,90293|LASS4,CERS4,79603|LIPC,LIPC,3990|LMOD3,LMOD3,56203|LPAR2,LPAR2,9170|LRRC30,LRRC30,339291|MARCH8,MARCHF8,220972|MED10,MED10,84246|MEPE,MEPE,56955|MIR124A-1,null,null|MIR144,MIR144,406936|MIR674,null,null|MIR99B,MIR99B,407056|MIRLET7A-1,null,null|MOXD1,MOXD1,26002|MRPS31,MRPS31,10240|MTBP,MTBP,27085|MUM1L1,PWWP3B,139221|NCKAP5L,NCKAP5L,57701|NDUFA10,NDUFA10,4705|NFKBID,NFKBID,84807|NLRP4F,null,null|NRCAM,NRCAM,4897|NUT,NUTM1,256646|OLFR1098,null,null|OLFR110,null,null|OLFR1107,null,null|OLFR1294,null,null|OLFR1412,null,null|OLFR835,null,null|OLFR891,null,null|OMP,OMP,4975|OTOG,OTOG,340990|OXTR,OXTR,5021|PDGFRB,PDGFRB,5159|PDIK1L,PDIK1L,149420|PDLIM2,PDLIM2,64236|PID1,PID1,55022|PILRA,PILRA,29992|PIR,PIR,8544|PLCXD2,PLCXD2,257068|PLIN1,PLIN1,5346|PM20D1,PM20D1,148811|POM121L2,POM121L2,94026|PRRG2,PRRG2,5639|PRTN3,PRTN3,5657|PTCD1,PTCD1,26024|PTGDR,PTGDR,5729|PTRF,CAVIN1,284119|RAB4B,RAB4B,53916|RABL5,IFT22,64792|RIMKLA,RIMKLA,284716|RNF152,RNF152,220441|RNF186,RNF186,54546|RNMTL1,MRM3,55178|RPL27A-PS2,null,null|RPN1,RPN1,6184|RPS4Y2,RPS4Y2,140032|RRAD,RRAD,6236|RUSC2,RUSC2,9853|SEC22B,SEC22B,9554|SELP,SELP,6403|SERPINA1D,null,null|SERPINB8,SERPINB8,5271|SEZ6,SEZ6,124925|SH3PXD2A,SH3PXD2A,9644|SHBG,SHBG,6462|SLC25A10,SLC25A10,1468|SLC31A1,SLC31A1,1317|SLC6A3,SLC6A3,6531|SLC7A13,SLC7A13,157724|SLCO4C1,SLCO4C1,353189|SMT3H2-PS,null,null|SMTNL1,SMTNL1,219537|SNRPB,SNRPB,6628|SNX18,SNX18,112574|SRGAP1,SRGAP1,57522|SSTR4,SSTR4,6754|TAGAP,TAGAP,117289|TARBP2,TARBP2,6895|TBC1D9B,TBC1D9B,23061|TCF7,TCF7,6932|TDRD12,TDRD12,91646|TEX13,null,null|TJP2,TJP2,9414|TM7SF3,TM7SF3,51768|TOMM34,TOMM34,10953|TTC25,ODAD4,83538|TYROBP,TYROBP,7305|UNC45A,UNC45A,55898|VMN1R42,null,null|VMN2R-PS33,null,null|VMN2R-PS57,null,null|VMN2R68,null,null|WAS,WAS,7454|WDR8,WRAP73,49856|XYLB,XYLB,9942|ZBTB7C,ZBTB7C,201501|ZEB2,ZEB2,9839|ZFP105,null,null|ZFP319,null,null|ZFP579,null,null|ZFP90,ZFP90,146198" FILTERED_BY_SIMILARITY="" FOUNDER_NAMES="" REFINEMENT_DATASETS="" VALIDATION_DATASETS="" CATEGORY_CODE="C7" ORGANISM="Mus musculus" SUB_CATEGORY_CODE="IMMUNESIGDB"/>
</MSIGDB>
